Normal to enhanced intrinsic mitochondrial respiration in skeletal muscle of middle- to older-aged women and men with uncomplicated type 1 diabetes

Aims/hypothesis This study interrogated mitochondrial respiratory function and content in skeletal muscle biopsies of healthy adults between 30 and 72 years old with and without uncomplicated type 1 diabetes. Methods Participants (12 women/nine men) with type 1 diabetes (48 ± 11 years of age), witho...

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Veröffentlicht in:	Diabetologia 2021-11, Vol.64 (11), p.2517-2533
Hauptverfasser:	Monaco, Cynthia M. F., Tarnopolsky, Mark A., Dial, Athan G., Nederveen, Joshua P., Rebalka, Irena A., Nguyen, Maria, Turner, Lauren V., Perry, Christopher G. R., Ljubicic, Vladimir, Hawke, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aerobic capacity Aged Biopsy Cardiorespiratory fitness Cell Respiration - physiology Citrate synthase Cristae Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - metabolism Electron microscopy Electron transport chain Electron Transport Complex I - metabolism Electron Transport Complex II - metabolism Endocrinology & Metabolism Female Human Physiology Humans Internal Medicine Life Sciences & Biomedicine Male Medicine Medicine & Public Health Mens health Metabolic Diseases Middle Aged Mitochondria Mitochondria, Muscle - metabolism Muscle, Skeletal - metabolism Musculoskeletal system Older people Oxidative Phosphorylation Oxygen Consumption - physiology Phosphorylation Physical activity Physical fitness Pyruvic acid Respiratory Mechanics Science & Technology Sexual dimorphism Skeletal muscle Women Womens health
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