Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Natural killer (NK) cells are innate cytotoxic lymphocytes that can recognize assorted determinants on tumor cells and rapidly kill these cells. Due to their anti-tumor effector functions and potential for allogeneic use, various NK cell platforms are being examined for adoptive cell therapies. Howe...

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Veröffentlicht in:	Frontiers in immunology 2021-07, Vol.12, p.711621-711621, Article 711621
Hauptverfasser:	Mishra, Hemant K., Dixon, Kate J., Pore, Nabendu, Felices, Martin, Miller, Jeffrey S., Walcheck, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM17 (a disintegrin and metalloprotease 17) ADAM17 Protein - antagonists & inhibitors ADAM17 Protein - immunology ADAM17 Protein - metabolism Adoptive Transfer Animals CD62L Cell Division Enzyme Activation Female Heterografts Humans IL-15 Immunology Interleukin-15 - metabolism Interleukin-15 - pharmacology Killer Cells, Natural - cytology Killer Cells, Natural - enzymology L-Selectin - metabolism Life Sciences & Biomedicine Mice Mice, Inbred NOD Mice, SCID natural killer cell proliferation Receptors, Cell Surface - metabolism Recombinant Proteins - pharmacology Science & Technology
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