Potential applications of alginate oligosaccharides for biomedicine – A mini review
Extensive research on marine algae, especially on their health-promoting properties, has been conducted. Various ingredients with potential biomedical applications have been discovered and extracted from marine algae. Alginate oligosaccharides are low molecular weight alginate polysaccharides presen...
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| Veröffentlicht in: | Carbohydrate polymers 2021-11, Vol.271, p.118408-118408, Article 118408 |
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| creator | Wang, Mingpeng Chen, Lei Zhang, Zhaojie |
| description | Extensive research on marine algae, especially on their health-promoting properties, has been conducted. Various ingredients with potential biomedical applications have been discovered and extracted from marine algae. Alginate oligosaccharides are low molecular weight alginate polysaccharides present in cell walls of brown algae. They exhibit various health benefits such as anti-inflammatory, anti-microbial, anti-oxidant, anti-tumor and immunomodulation. Their low-toxicity, non-immunogenicity, and biodegradability make them an excellent material in biomedicine. Alginate oligosaccharides can be chemically or biochemically modified to enhance their biological activity and potential in pharmaceutical applications. This paper provides a brief overview on alginate oligosaccharides characteristics, modification patterns and highlights their vital health promoting properties.
•Alginate oligosaccharide has good biosafety, biocompatibility and bioavailability.•Composition and structure of oligosaccharide affects its final biological activity.•Alginate oligosaccharides are potential biomedicines with promising prospects. |
| doi_str_mv | 10.1016/j.carbpol.2021.118408 |
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•Alginate oligosaccharide has good biosafety, biocompatibility and bioavailability.•Composition and structure of oligosaccharide affects its final biological activity.•Alginate oligosaccharides are potential biomedicines with promising prospects.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2021.118408</identifier><identifier>PMID: 34364551</identifier><language>eng</language><publisher>OXFORD: Elsevier Ltd</publisher><subject>Alginate oligosaccharides ; Alginates - chemical synthesis ; Alginates - therapeutic use ; Animals ; Biomedicine ; Brown algae ; Cell Line, Tumor ; Chemistry ; Chemistry, Applied ; Chemistry, Organic ; Clinical Trials as Topic ; Drug Carriers - chemistry ; Health-promoting ; Humans ; Oligosaccharides - chemical synthesis ; Oligosaccharides - therapeutic use ; Physical Sciences ; Polymer Science ; Science & Technology</subject><ispartof>Carbohydrate polymers, 2021-11, Vol.271, p.118408-118408, Article 118408</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>71</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000685005000004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c464t-b5ef77ae2c6e8c1172d1214d85b04a2bfd77a4fca9a8b4b3a9588e93393940c83</citedby><cites>FETCH-LOGICAL-c464t-b5ef77ae2c6e8c1172d1214d85b04a2bfd77a4fca9a8b4b3a9588e93393940c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2021.118408$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,39267,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34364551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Mingpeng</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Zhang, Zhaojie</creatorcontrib><title>Potential applications of alginate oligosaccharides for biomedicine – A mini review</title><title>Carbohydrate polymers</title><addtitle>CARBOHYD POLYM</addtitle><addtitle>Carbohydr Polym</addtitle><description>Extensive research on marine algae, especially on their health-promoting properties, has been conducted. Various ingredients with potential biomedical applications have been discovered and extracted from marine algae. Alginate oligosaccharides are low molecular weight alginate polysaccharides present in cell walls of brown algae. They exhibit various health benefits such as anti-inflammatory, anti-microbial, anti-oxidant, anti-tumor and immunomodulation. Their low-toxicity, non-immunogenicity, and biodegradability make them an excellent material in biomedicine. Alginate oligosaccharides can be chemically or biochemically modified to enhance their biological activity and potential in pharmaceutical applications. This paper provides a brief overview on alginate oligosaccharides characteristics, modification patterns and highlights their vital health promoting properties.
•Alginate oligosaccharide has good biosafety, biocompatibility and bioavailability.•Composition and structure of oligosaccharide affects its final biological activity.•Alginate oligosaccharides are potential biomedicines with promising prospects.</description><subject>Alginate oligosaccharides</subject><subject>Alginates - chemical synthesis</subject><subject>Alginates - therapeutic use</subject><subject>Animals</subject><subject>Biomedicine</subject><subject>Brown algae</subject><subject>Cell Line, Tumor</subject><subject>Chemistry</subject><subject>Chemistry, Applied</subject><subject>Chemistry, Organic</subject><subject>Clinical Trials as Topic</subject><subject>Drug Carriers - chemistry</subject><subject>Health-promoting</subject><subject>Humans</subject><subject>Oligosaccharides - chemical synthesis</subject><subject>Oligosaccharides - therapeutic use</subject><subject>Physical Sciences</subject><subject>Polymer Science</subject><subject>Science & Technology</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkEFu1DAUQC0EotPCEUBeIqFM_RM7sVeoGlGKVKks6NqynZ_iUSYOtqcVO-7ADTlJPWToFrz5C79n6z9C3gBbA4P2fLt2Jto5jOua1bAGkJzJZ2QFslMVNJw_JysGnFeyhe6EnKa0ZeW0wF6Sk4Y3LRcCVuT2S8g4ZW9GauZ59M5kH6ZEw0DNeOcnk5GG0d-FZJz7ZqLvMdEhRGp92GHvnZ-Q_v75i17QnZ88jXjv8eEVeTGYMeHr4zwjt5cfv26uquubT583F9eV4y3PlRU4dJ3B2rUoHUBX91AD76WwjJvaDn255YMzykjLbWOUkBJV06hGceZkc0beLe_OMXzfY8p655PDcTQThn3StRCq7YApVVCxoC6GlCIOeo5-Z-IPDUwfiuqtPhbVh6J6KVq8t8cv9rYs_GT9TVgAuQAPaMOQnMfJ4RN2SC4FY-IQn_GNz38Cb8J-ykV9__9qoT8sNJaipXLUR6P3EV3WffD_2OURYA-rwQ</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Wang, Mingpeng</creator><creator>Chen, Lei</creator><creator>Zhang, Zhaojie</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211101</creationdate><title>Potential applications of alginate oligosaccharides for biomedicine – A mini review</title><author>Wang, Mingpeng ; Chen, Lei ; Zhang, Zhaojie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-b5ef77ae2c6e8c1172d1214d85b04a2bfd77a4fca9a8b4b3a9588e93393940c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alginate oligosaccharides</topic><topic>Alginates - chemical synthesis</topic><topic>Alginates - therapeutic use</topic><topic>Animals</topic><topic>Biomedicine</topic><topic>Brown algae</topic><topic>Cell Line, Tumor</topic><topic>Chemistry</topic><topic>Chemistry, Applied</topic><topic>Chemistry, Organic</topic><topic>Clinical Trials as Topic</topic><topic>Drug Carriers - chemistry</topic><topic>Health-promoting</topic><topic>Humans</topic><topic>Oligosaccharides - chemical synthesis</topic><topic>Oligosaccharides - therapeutic use</topic><topic>Physical Sciences</topic><topic>Polymer Science</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Mingpeng</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Zhang, Zhaojie</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Mingpeng</au><au>Chen, Lei</au><au>Zhang, Zhaojie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential applications of alginate oligosaccharides for biomedicine – A mini review</atitle><jtitle>Carbohydrate polymers</jtitle><stitle>CARBOHYD POLYM</stitle><addtitle>Carbohydr Polym</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>271</volume><spage>118408</spage><epage>118408</epage><pages>118408-118408</pages><artnum>118408</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>Extensive research on marine algae, especially on their health-promoting properties, has been conducted. Various ingredients with potential biomedical applications have been discovered and extracted from marine algae. Alginate oligosaccharides are low molecular weight alginate polysaccharides present in cell walls of brown algae. They exhibit various health benefits such as anti-inflammatory, anti-microbial, anti-oxidant, anti-tumor and immunomodulation. Their low-toxicity, non-immunogenicity, and biodegradability make them an excellent material in biomedicine. Alginate oligosaccharides can be chemically or biochemically modified to enhance their biological activity and potential in pharmaceutical applications. This paper provides a brief overview on alginate oligosaccharides characteristics, modification patterns and highlights their vital health promoting properties.
•Alginate oligosaccharide has good biosafety, biocompatibility and bioavailability.•Composition and structure of oligosaccharide affects its final biological activity.•Alginate oligosaccharides are potential biomedicines with promising prospects.</abstract><cop>OXFORD</cop><pub>Elsevier Ltd</pub><pmid>34364551</pmid><doi>10.1016/j.carbpol.2021.118408</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alginate oligosaccharides Alginates - chemical synthesis Alginates - therapeutic use Animals Biomedicine Brown algae Cell Line, Tumor Chemistry Chemistry, Applied Chemistry, Organic Clinical Trials as Topic Drug Carriers - chemistry Health-promoting Humans Oligosaccharides - chemical synthesis Oligosaccharides - therapeutic use Physical Sciences Polymer Science Science & Technology |
| title | Potential applications of alginate oligosaccharides for biomedicine – A mini review |
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