Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy
Small interfering RNA (siRNA)-based gene therapy has been widely studied as a promising treatment for malignant triple-negative breast cancer (TNBC), but efficient delivery of siRNA still remains a challenge. In this study, a smart manganese dioxide (MnO2)-based lanthanide nanoprobe therapeutic nano...
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| Veröffentlicht in: | ACS applied materials & interfaces 2021-08, Vol.13 (30), p.35444-35455 |
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| creator | Ming, Liyan Song, Liang Xu, Jixuan Wang, Ruoping Shi, Junpeng Chen, Min Zhang, Yun |
| description | Small interfering RNA (siRNA)-based gene therapy has been widely studied as a promising treatment for malignant triple-negative breast cancer (TNBC), but efficient delivery of siRNA still remains a challenge. In this study, a smart manganese dioxide (MnO2)-based lanthanide nanoprobe therapeutic nanoplatform (ErNPs@MnO2-siS100A4-RGD) was developed for tumor imaging and precise stimuli-responsive S100A4 siRNA (siS100A4)-mediated gene therapy in synergism with chemodynamic therapy (CDT) of TNBC. ErNPs@MnO2-siS100A4-RGD has a tumor microenvironment-responsive capability attributed to the presence of MnO2, which can be degraded by glutathione (GSH) in the tumor region while releasing siRNA and generating Mn2+ to achieve precise gene therapy and a Fenton-like reaction-mediated CDT effect on TNBC. Subsequently, the lanthanide nanoprobes (ErNPs) are exposed to the second near-infrared region (NIR-II) fluorescence emission to realize the precise tumor location. Both the in vitro and in vivo results demonstrated that the smart nanoplatform possessed high siRNA delivery efficiency and GSH-responsive precise siRNA releasing ability, and compared with individual gene therapy, the GSH-depletion-enhanced CDT effect further reinforced TNBC inhibition, demonstrating excellent GSH-responsive-enhanced NIR-II precise tumor imaging therapy. These results indicate that the nanoplatform provides a crucial foundation for further research on theranostic systems of TNBC. |
| doi_str_mv | 10.1021/acsami.1c08927 |
| format | Article |
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In this study, a smart manganese dioxide (MnO2)-based lanthanide nanoprobe therapeutic nanoplatform (ErNPs@MnO2-siS100A4-RGD) was developed for tumor imaging and precise stimuli-responsive S100A4 siRNA (siS100A4)-mediated gene therapy in synergism with chemodynamic therapy (CDT) of TNBC. ErNPs@MnO2-siS100A4-RGD has a tumor microenvironment-responsive capability attributed to the presence of MnO2, which can be degraded by glutathione (GSH) in the tumor region while releasing siRNA and generating Mn2+ to achieve precise gene therapy and a Fenton-like reaction-mediated CDT effect on TNBC. Subsequently, the lanthanide nanoprobes (ErNPs) are exposed to the second near-infrared region (NIR-II) fluorescence emission to realize the precise tumor location. Both the in vitro and in vivo results demonstrated that the smart nanoplatform possessed high siRNA delivery efficiency and GSH-responsive precise siRNA releasing ability, and compared with individual gene therapy, the GSH-depletion-enhanced CDT effect further reinforced TNBC inhibition, demonstrating excellent GSH-responsive-enhanced NIR-II precise tumor imaging therapy. These results indicate that the nanoplatform provides a crucial foundation for further research on theranostic systems of TNBC.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.1c08927</identifier><identifier>PMID: 34292714</identifier><language>eng</language><publisher>WASHINGTON: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - therapeutic use ; Biological and Medical Applications of Materials and Interfaces ; Cell Line, Tumor ; Down-Regulation - drug effects ; Drug Carriers - chemistry ; Drug Therapy ; Erbium - chemistry ; Genetic Therapy ; Glutathione - metabolism ; Humans ; Manganese Compounds - chemistry ; Manganese Compounds - metabolism ; Materials Science ; Materials Science, Multidisciplinary ; Metal Nanoparticles - chemistry ; Mice ; Mice, Nude ; Nanoscience & Nanotechnology ; Oxides - chemistry ; Oxides - metabolism ; RNA, Small Interfering - therapeutic use ; S100 Calcium-Binding Protein A4 - metabolism ; Science & Technology ; Science & Technology - Other Topics ; Technology ; Triple Negative Breast Neoplasms - diagnostic imaging ; Triple Negative Breast Neoplasms - therapy ; Xenograft Model Antitumor Assays</subject><ispartof>ACS applied materials & interfaces, 2021-08, Vol.13 (30), p.35444-35455</ispartof><rights>2021 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>37</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000683741400018</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-a330t-c352c59fbecca1c383e0d0605eca373db8053077b4594000062bb1f5a49a66943</citedby><cites>FETCH-LOGICAL-a330t-c352c59fbecca1c383e0d0605eca373db8053077b4594000062bb1f5a49a66943</cites><orcidid>0000-0001-6288-4671</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.1c08927$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.1c08927$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,782,786,2769,27085,27933,27934,39267,56747,56797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34292714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ming, Liyan</creatorcontrib><creatorcontrib>Song, Liang</creatorcontrib><creatorcontrib>Xu, Jixuan</creatorcontrib><creatorcontrib>Wang, Ruoping</creatorcontrib><creatorcontrib>Shi, Junpeng</creatorcontrib><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Zhang, Yun</creatorcontrib><title>Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy</title><title>ACS applied materials & interfaces</title><addtitle>ACS APPL MATER INTER</addtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>Small interfering RNA (siRNA)-based gene therapy has been widely studied as a promising treatment for malignant triple-negative breast cancer (TNBC), but efficient delivery of siRNA still remains a challenge. In this study, a smart manganese dioxide (MnO2)-based lanthanide nanoprobe therapeutic nanoplatform (ErNPs@MnO2-siS100A4-RGD) was developed for tumor imaging and precise stimuli-responsive S100A4 siRNA (siS100A4)-mediated gene therapy in synergism with chemodynamic therapy (CDT) of TNBC. ErNPs@MnO2-siS100A4-RGD has a tumor microenvironment-responsive capability attributed to the presence of MnO2, which can be degraded by glutathione (GSH) in the tumor region while releasing siRNA and generating Mn2+ to achieve precise gene therapy and a Fenton-like reaction-mediated CDT effect on TNBC. Subsequently, the lanthanide nanoprobes (ErNPs) are exposed to the second near-infrared region (NIR-II) fluorescence emission to realize the precise tumor location. Both the in vitro and in vivo results demonstrated that the smart nanoplatform possessed high siRNA delivery efficiency and GSH-responsive precise siRNA releasing ability, and compared with individual gene therapy, the GSH-depletion-enhanced CDT effect further reinforced TNBC inhibition, demonstrating excellent GSH-responsive-enhanced NIR-II precise tumor imaging therapy. These results indicate that the nanoplatform provides a crucial foundation for further research on theranostic systems of TNBC.</description><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and Medical Applications of Materials and Interfaces</subject><subject>Cell Line, Tumor</subject><subject>Down-Regulation - drug effects</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Therapy</subject><subject>Erbium - chemistry</subject><subject>Genetic Therapy</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Manganese Compounds - chemistry</subject><subject>Manganese Compounds - metabolism</subject><subject>Materials Science</subject><subject>Materials Science, Multidisciplinary</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Nanoscience & Nanotechnology</subject><subject>Oxides - chemistry</subject><subject>Oxides - metabolism</subject><subject>RNA, Small Interfering - therapeutic use</subject><subject>S100 Calcium-Binding Protein A4 - metabolism</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Technology</subject><subject>Triple Negative Breast Neoplasms - diagnostic imaging</subject><subject>Triple Negative Breast Neoplasms - therapy</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkElPwzAQRi0EYr9yRD6DUuzY2Y4QVqksEuUcTZxJa0TtyE6BnvnjuAr0hoQvtqz3jb55hBxxNuIs5megPMz1iCuWF3G2QXZ5IWWUx0m8uX5LuUP2vH9lLBUxS7bJjpBxoLncJV_Pc3A9vQczBYMe6aW2n7rB6AI8NnQMpp-BCR_0AYztnK3R09Y6OnG6e8PoAafQ63ekFw7B97QEo9DRJ4dKh2k3aJA-Lw26qfa9VrSc4dw2SxNKKzqZoYNueUC2WnjzePhz75OX66tJeRuNH2_uyvNxBEKwPlIiiVVStDUqBVyJXCBrWMoSVCAy0dQ5SwTLslomhWThpHFd8zYBWUCaFlLsk9EwVznrvcO26pwO6y8rzqqVzWqwWf3YDIHjIdAt6jk2a_xXXwBOB-ADa9t6pTFsv8ZWFXKRSb5qw_NA5_-nS90HsdaUdmH6ED0ZoqFh9WoXzgRRf9X-BnxYobw</recordid><startdate>20210804</startdate><enddate>20210804</enddate><creator>Ming, Liyan</creator><creator>Song, Liang</creator><creator>Xu, Jixuan</creator><creator>Wang, Ruoping</creator><creator>Shi, Junpeng</creator><creator>Chen, Min</creator><creator>Zhang, Yun</creator><general>American Chemical Society</general><general>Amer Chemical Soc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-6288-4671</orcidid></search><sort><creationdate>20210804</creationdate><title>Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy</title><author>Ming, Liyan ; Song, Liang ; Xu, Jixuan ; Wang, Ruoping ; Shi, Junpeng ; Chen, Min ; Zhang, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-c352c59fbecca1c383e0d0605eca373db8053077b4594000062bb1f5a49a66943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and Medical Applications of Materials and Interfaces</topic><topic>Cell Line, Tumor</topic><topic>Down-Regulation - drug effects</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Therapy</topic><topic>Erbium - chemistry</topic><topic>Genetic Therapy</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Manganese Compounds - chemistry</topic><topic>Manganese Compounds - metabolism</topic><topic>Materials Science</topic><topic>Materials Science, Multidisciplinary</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Nanoscience & Nanotechnology</topic><topic>Oxides - chemistry</topic><topic>Oxides - metabolism</topic><topic>RNA, Small Interfering - therapeutic use</topic><topic>S100 Calcium-Binding Protein A4 - metabolism</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><topic>Technology</topic><topic>Triple Negative Breast Neoplasms - diagnostic imaging</topic><topic>Triple Negative Breast Neoplasms - therapy</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ming, Liyan</creatorcontrib><creatorcontrib>Song, Liang</creatorcontrib><creatorcontrib>Xu, Jixuan</creatorcontrib><creatorcontrib>Wang, Ruoping</creatorcontrib><creatorcontrib>Shi, Junpeng</creatorcontrib><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Zhang, Yun</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ming, Liyan</au><au>Song, Liang</au><au>Xu, Jixuan</au><au>Wang, Ruoping</au><au>Shi, Junpeng</au><au>Chen, Min</au><au>Zhang, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy</atitle><jtitle>ACS applied materials & interfaces</jtitle><stitle>ACS APPL MATER INTER</stitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2021-08-04</date><risdate>2021</risdate><volume>13</volume><issue>30</issue><spage>35444</spage><epage>35455</epage><pages>35444-35455</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Small interfering RNA (siRNA)-based gene therapy has been widely studied as a promising treatment for malignant triple-negative breast cancer (TNBC), but efficient delivery of siRNA still remains a challenge. In this study, a smart manganese dioxide (MnO2)-based lanthanide nanoprobe therapeutic nanoplatform (ErNPs@MnO2-siS100A4-RGD) was developed for tumor imaging and precise stimuli-responsive S100A4 siRNA (siS100A4)-mediated gene therapy in synergism with chemodynamic therapy (CDT) of TNBC. ErNPs@MnO2-siS100A4-RGD has a tumor microenvironment-responsive capability attributed to the presence of MnO2, which can be degraded by glutathione (GSH) in the tumor region while releasing siRNA and generating Mn2+ to achieve precise gene therapy and a Fenton-like reaction-mediated CDT effect on TNBC. Subsequently, the lanthanide nanoprobes (ErNPs) are exposed to the second near-infrared region (NIR-II) fluorescence emission to realize the precise tumor location. Both the in vitro and in vivo results demonstrated that the smart nanoplatform possessed high siRNA delivery efficiency and GSH-responsive precise siRNA releasing ability, and compared with individual gene therapy, the GSH-depletion-enhanced CDT effect further reinforced TNBC inhibition, demonstrating excellent GSH-responsive-enhanced NIR-II precise tumor imaging therapy. These results indicate that the nanoplatform provides a crucial foundation for further research on theranostic systems of TNBC.</abstract><cop>WASHINGTON</cop><pub>American Chemical Society</pub><pmid>34292714</pmid><doi>10.1021/acsami.1c08927</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6288-4671</orcidid></addata></record> |
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| subjects | Animals Antineoplastic Agents - therapeutic use Biological and Medical Applications of Materials and Interfaces Cell Line, Tumor Down-Regulation - drug effects Drug Carriers - chemistry Drug Therapy Erbium - chemistry Genetic Therapy Glutathione - metabolism Humans Manganese Compounds - chemistry Manganese Compounds - metabolism Materials Science Materials Science, Multidisciplinary Metal Nanoparticles - chemistry Mice Mice, Nude Nanoscience & Nanotechnology Oxides - chemistry Oxides - metabolism RNA, Small Interfering - therapeutic use S100 Calcium-Binding Protein A4 - metabolism Science & Technology Science & Technology - Other Topics Technology Triple Negative Breast Neoplasms - diagnostic imaging Triple Negative Breast Neoplasms - therapy Xenograft Model Antitumor Assays |
| title | Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy |
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