Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery
Natural products (NPs) have a long history as sources of compounds for crop protection. Perhaps a more important role for NPs has been as models and inspiration for the discovery and development of synthetic crop protection compounds. NPs and their synthetic mimics account for 18% of all crop protec...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2021-08, Vol.69 (30), p.8324-8346 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Sparks, Thomas C Duke, Stephen O |
| description | Natural products (NPs) have a long history as sources of compounds for crop protection. Perhaps a more important role for NPs has been as models and inspiration for the discovery and development of synthetic crop protection compounds. NPs and their synthetic mimics account for 18% of all crop protection compounds, whereas another 38% of all crop protection compounds have a NP that could have served as a model. Because NPs are often complex molecules, have limited availability, or possess structural features that constrain their suitability for use in agricultural settings, a key element in NP-inspired compounds is the simplification of the NP structure to provide a synthetically accessible molecule that possesses the physicochemical properties needed for use in crop protection. Herein we review a series of examples of NP mimics that demonstrate the structural or synthetic simplification of NPs as a guide for the discovery of future NP-inspired agrochemicals focused on fungicides, herbicides, and insecticides. |
| doi_str_mv | 10.1021/acs.jafc.1c02616 |
| format | Article |
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| source | MEDLINE; ACS Publications; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Agriculture Agriculture, Multidisciplinary Agrochemicals Biological Products Chemistry Chemistry, Applied Crop Protection Food Science & Technology Fungicides, Industrial Insecticides Life Sciences & Biomedicine Physical Sciences Science & Technology |
| title | Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery |
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