CaMKII and Ca V 3.2 T-type calcium channel mediate Connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain

Vincristine (VCR), an alkaloid isolated from vinca, is a commonly used chemotherapeutic drug. However, VCR therapy can lead to dose-dependent peripheral neurotoxicity, mainly manifesting as neuropathic pain, which is one of the dominant reasons for limiting its utility. Experimentally, we discovered...

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Veröffentlicht in:	Cell biology and toxicology 2023-06, Vol.39 (3), p.679
Hauptverfasser:	Li, Gui-Zhou, Hu, Ya-Hui, Lu, Yi-Ni, Yang, Qing-Yan, Fu, Di, Chen, Feng, Li, Yun-Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes - metabolism Calcium Channels, T-Type - metabolism Calcium Channels, T-Type - therapeutic use Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - therapeutic use Connexin 43 - genetics Connexin 43 - metabolism Humans Neuralgia - chemically induced Neuralgia - drug therapy Neuralgia - metabolism Vincristine - metabolism Vincristine - pharmacology Vincristine - therapeutic use
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