Population Pharmacokinetic Analysis of N‐Acetylcysteine in Pediatric Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplant

N‐acetylcysteine (NAC) has been used in patients with cerebral adrenoleukodystrophy as an antioxidant agent in association with hematopoietic stem cell transplant (HSCT). However, an understanding of the pharmacokinetic characteristics of intravenous NAC dosing in these patients is limited. If and h...

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Veröffentlicht in:	Journal of clinical pharmacology 2021-12, Vol.61 (12), p.1638-1645
Hauptverfasser:	Sahasrabudhe, Siddhee A., Kartha, Reena V., Ng, Michelle, Basso, Lisa M., Mishra, Usha, Cloyd, James C., Orchard, Paul J., Brundage, Richard C., Coles, Lisa D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacokinetics Adolescent Adrenoleukodystrophy Antioxidants Child Child, Preschool Dosage Female Half-Life Hematopoietic stem cell transplant Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Inherited metabolic disorders Intravenous administration Life Sciences & Biomedicine Male Metabolic Clearance Rate Metabolic disorders Metabolism, Inborn Errors - metabolism Models, Biological N‐acetylcysteine Patients Pediatric Pediatrics Pharmacokinetics Pharmacology & Pharmacy Population pharmacokinetics Prospective Studies Science & Technology Stem cell transplantation Time Factors Young Adult
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