The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice
In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induce...
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| creator | Zhang, Jin Zhou, Hong-Chang He, Shuai-Bing Zhang, Xiu-Fang Ling, Yu-Hang Li, Xiao-Yu Zhang, Hui Hou, Dian-Dong |
| description | In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induced by CTX. Compared with immunosuppressive mice induced by CTX, SBT pulp oil could enhance NK cytotoxicity, macrophage phagocytosis, and T lymphocyte proliferation, and regulate the proportion of T cell subsets in mesenteric lymph nodes (MLN), and promote the production of secretory immunoglobulin A (sIgA), IFN-γ, IL-2, IL-4, IL-12 and TNF-α in the intestines. In addition, SBT pulp oil can promote the production of short fatty acids (SCFAs), increase the diversity of gut microbiota, improve the composition of intestinal flora, increase the abundance of
Alistipes
,
Bacteroide
s,
Anaerotruncus
,
Lactobacillus
,
ASF356
, and
Roseburia
, while decreasing the abundance of
Mucispirillum, Anaeroplasma, Pelagibacterium, Brevundimonas, Ochrobactrum, Acinetobacter, Ruminiclostridium, Blautia, Ruminiclostridium, Oscillibacter
, and
Faecalibaculum
. This study shows that SBT pulp oil can regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive Balb/c mice, thus enhancing the intestinal mucosa and systemic immune response. The results can provide a basis for understanding the function of SBT pulp oil and its application as a new probiotic and immunomodulator.
This study shows that SBT pulp oil can promote the concentrations of SCFAs and regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive BALB/c mice, thus enhancing the intestinal mucosa and systemic immune functions. |
| doi_str_mv | 10.1039/d1fo01257f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_34251375</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2566256279</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-f3126e1fc22d81615bb8a634c79d15c531c1936ef1d232db45305414cfe639b93</originalsourceid><addsrcrecordid>eNpdkc1LHjEQxkNpqWK9eFcCvRRha753cyzqqwXBi4K3ZTeZsNHdZE02B_97176vFhwYZpj58TDMg9ARJb8p4frMUhcJZbJ2X9A-I4JVSpKHr--90GoPHeb8SNbgWje6-Y72uGCS8lruI383APbTVEKEMHTBwARhweAcmCXj6HCGDvfFPC1DTAHPZZxx9CP2AZsXM8Z5iHkeuslbqHywxYDd6eUyzwlyXgeTN_ADfXPdmOFwVw_Q_eby7vy6urm9-nv-56YyvG6WynHKFFBnGLMNVVT2fdMpLkytLZVGcmqo5goctYwz2wvJiRRUGAeK617zA_Rrqzun-FwgL-3ks4Fx7ALEklsmJVFMSCpW9Ocn9DGWFNbrVkqpNVn9Jni6pUyKOSdw7Zz81KWXlpL2zYP2gm5u_3mwWeGTnWTpJ7Af6PvHV-B4C6RsPrb_TeSvZr-Lvg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2566256279</pqid></control><display><type>article</type><title>The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Zhang, Jin ; Zhou, Hong-Chang ; He, Shuai-Bing ; Zhang, Xiu-Fang ; Ling, Yu-Hang ; Li, Xiao-Yu ; Zhang, Hui ; Hou, Dian-Dong</creator><creatorcontrib>Zhang, Jin ; Zhou, Hong-Chang ; He, Shuai-Bing ; Zhang, Xiu-Fang ; Ling, Yu-Hang ; Li, Xiao-Yu ; Zhang, Hui ; Hou, Dian-Dong</creatorcontrib><description>In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induced by CTX. Compared with immunosuppressive mice induced by CTX, SBT pulp oil could enhance NK cytotoxicity, macrophage phagocytosis, and T lymphocyte proliferation, and regulate the proportion of T cell subsets in mesenteric lymph nodes (MLN), and promote the production of secretory immunoglobulin A (sIgA), IFN-γ, IL-2, IL-4, IL-12 and TNF-α in the intestines. In addition, SBT pulp oil can promote the production of short fatty acids (SCFAs), increase the diversity of gut microbiota, improve the composition of intestinal flora, increase the abundance of
Alistipes
,
Bacteroide
s,
Anaerotruncus
,
Lactobacillus
,
ASF356
, and
Roseburia
, while decreasing the abundance of
Mucispirillum, Anaeroplasma, Pelagibacterium, Brevundimonas, Ochrobactrum, Acinetobacter, Ruminiclostridium, Blautia, Ruminiclostridium, Oscillibacter
, and
Faecalibaculum
. This study shows that SBT pulp oil can regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive Balb/c mice, thus enhancing the intestinal mucosa and systemic immune response. The results can provide a basis for understanding the function of SBT pulp oil and its application as a new probiotic and immunomodulator.
This study shows that SBT pulp oil can promote the concentrations of SCFAs and regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive BALB/c mice, thus enhancing the intestinal mucosa and systemic immune functions.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo01257f</identifier><identifier>PMID: 34251375</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Abundance ; Animals ; Body weight ; Composition ; Cyclophosphamide ; Cyclophosphamide - adverse effects ; Cytotoxicity ; Fatty acids ; Female ; Flora ; Gastrointestinal Microbiome - drug effects ; Hippophae - chemistry ; Humans ; Immune response ; Immune system ; Immunocompromised Host - drug effects ; Immunoglobulin A ; Immunomodulating Agents - administration & dosage ; Immunomodulation ; Immunomodulators ; Immunosuppressive Agents - adverse effects ; Inflammation - drug therapy ; Inflammation - etiology ; Inflammation - immunology ; Interleukin 12 ; Interleukin 2 ; Interleukin 4 ; Intestinal microflora ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - microbiology ; Intestine ; Lymph nodes ; Lymphocytes ; Lymphocytes T ; Macrophages ; Mice ; Mice, Inbred BALB C ; Microbiota ; Mucosa ; Oil ; Phagocytosis ; Plant Oils - administration & dosage ; Probiotics ; Spleen ; Toxicity ; Tumor necrosis factor-α ; γ-Interferon</subject><ispartof>Food & function, 2021-09, Vol.12 (17), p.7954-7963</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-f3126e1fc22d81615bb8a634c79d15c531c1936ef1d232db45305414cfe639b93</citedby><cites>FETCH-LOGICAL-c378t-f3126e1fc22d81615bb8a634c79d15c531c1936ef1d232db45305414cfe639b93</cites><orcidid>0000-0002-2260-8506</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34251375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jin</creatorcontrib><creatorcontrib>Zhou, Hong-Chang</creatorcontrib><creatorcontrib>He, Shuai-Bing</creatorcontrib><creatorcontrib>Zhang, Xiu-Fang</creatorcontrib><creatorcontrib>Ling, Yu-Hang</creatorcontrib><creatorcontrib>Li, Xiao-Yu</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Hou, Dian-Dong</creatorcontrib><title>The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induced by CTX. Compared with immunosuppressive mice induced by CTX, SBT pulp oil could enhance NK cytotoxicity, macrophage phagocytosis, and T lymphocyte proliferation, and regulate the proportion of T cell subsets in mesenteric lymph nodes (MLN), and promote the production of secretory immunoglobulin A (sIgA), IFN-γ, IL-2, IL-4, IL-12 and TNF-α in the intestines. In addition, SBT pulp oil can promote the production of short fatty acids (SCFAs), increase the diversity of gut microbiota, improve the composition of intestinal flora, increase the abundance of
Alistipes
,
Bacteroide
s,
Anaerotruncus
,
Lactobacillus
,
ASF356
, and
Roseburia
, while decreasing the abundance of
Mucispirillum, Anaeroplasma, Pelagibacterium, Brevundimonas, Ochrobactrum, Acinetobacter, Ruminiclostridium, Blautia, Ruminiclostridium, Oscillibacter
, and
Faecalibaculum
. This study shows that SBT pulp oil can regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive Balb/c mice, thus enhancing the intestinal mucosa and systemic immune response. The results can provide a basis for understanding the function of SBT pulp oil and its application as a new probiotic and immunomodulator.
This study shows that SBT pulp oil can promote the concentrations of SCFAs and regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive BALB/c mice, thus enhancing the intestinal mucosa and systemic immune functions.</description><subject>Abundance</subject><subject>Animals</subject><subject>Body weight</subject><subject>Composition</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cytotoxicity</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Flora</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Hippophae - chemistry</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunocompromised Host - drug effects</subject><subject>Immunoglobulin A</subject><subject>Immunomodulating Agents - administration & dosage</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - etiology</subject><subject>Inflammation - immunology</subject><subject>Interleukin 12</subject><subject>Interleukin 2</subject><subject>Interleukin 4</subject><subject>Intestinal microflora</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestine</subject><subject>Lymph nodes</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiota</subject><subject>Mucosa</subject><subject>Oil</subject><subject>Phagocytosis</subject><subject>Plant Oils - administration & dosage</subject><subject>Probiotics</subject><subject>Spleen</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-α</subject><subject>γ-Interferon</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1LHjEQxkNpqWK9eFcCvRRha753cyzqqwXBi4K3ZTeZsNHdZE02B_97176vFhwYZpj58TDMg9ARJb8p4frMUhcJZbJ2X9A-I4JVSpKHr--90GoPHeb8SNbgWje6-Y72uGCS8lruI383APbTVEKEMHTBwARhweAcmCXj6HCGDvfFPC1DTAHPZZxx9CP2AZsXM8Z5iHkeuslbqHywxYDd6eUyzwlyXgeTN_ADfXPdmOFwVw_Q_eby7vy6urm9-nv-56YyvG6WynHKFFBnGLMNVVT2fdMpLkytLZVGcmqo5goctYwz2wvJiRRUGAeK617zA_Rrqzun-FwgL-3ks4Fx7ALEklsmJVFMSCpW9Ocn9DGWFNbrVkqpNVn9Jni6pUyKOSdw7Zz81KWXlpL2zYP2gm5u_3mwWeGTnWTpJ7Af6PvHV-B4C6RsPrb_TeSvZr-Lvg</recordid><startdate>20210907</startdate><enddate>20210907</enddate><creator>Zhang, Jin</creator><creator>Zhou, Hong-Chang</creator><creator>He, Shuai-Bing</creator><creator>Zhang, Xiu-Fang</creator><creator>Ling, Yu-Hang</creator><creator>Li, Xiao-Yu</creator><creator>Zhang, Hui</creator><creator>Hou, Dian-Dong</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2260-8506</orcidid></search><sort><creationdate>20210907</creationdate><title>The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice</title><author>Zhang, Jin ; Zhou, Hong-Chang ; He, Shuai-Bing ; Zhang, Xiu-Fang ; Ling, Yu-Hang ; Li, Xiao-Yu ; Zhang, Hui ; Hou, Dian-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-f3126e1fc22d81615bb8a634c79d15c531c1936ef1d232db45305414cfe639b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abundance</topic><topic>Animals</topic><topic>Body weight</topic><topic>Composition</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Cytotoxicity</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Flora</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Hippophae - chemistry</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunocompromised Host - drug effects</topic><topic>Immunoglobulin A</topic><topic>Immunomodulating Agents - administration & dosage</topic><topic>Immunomodulation</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - etiology</topic><topic>Inflammation - immunology</topic><topic>Interleukin 12</topic><topic>Interleukin 2</topic><topic>Interleukin 4</topic><topic>Intestinal microflora</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestine</topic><topic>Lymph nodes</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiota</topic><topic>Mucosa</topic><topic>Oil</topic><topic>Phagocytosis</topic><topic>Plant Oils - administration & dosage</topic><topic>Probiotics</topic><topic>Spleen</topic><topic>Toxicity</topic><topic>Tumor necrosis factor-α</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jin</creatorcontrib><creatorcontrib>Zhou, Hong-Chang</creatorcontrib><creatorcontrib>He, Shuai-Bing</creatorcontrib><creatorcontrib>Zhang, Xiu-Fang</creatorcontrib><creatorcontrib>Ling, Yu-Hang</creatorcontrib><creatorcontrib>Li, Xiao-Yu</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Hou, Dian-Dong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jin</au><au>Zhou, Hong-Chang</au><au>He, Shuai-Bing</au><au>Zhang, Xiu-Fang</au><au>Ling, Yu-Hang</au><au>Li, Xiao-Yu</au><au>Zhang, Hui</au><au>Hou, Dian-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-09-07</date><risdate>2021</risdate><volume>12</volume><issue>17</issue><spage>7954</spage><epage>7963</epage><pages>7954-7963</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induced by CTX. Compared with immunosuppressive mice induced by CTX, SBT pulp oil could enhance NK cytotoxicity, macrophage phagocytosis, and T lymphocyte proliferation, and regulate the proportion of T cell subsets in mesenteric lymph nodes (MLN), and promote the production of secretory immunoglobulin A (sIgA), IFN-γ, IL-2, IL-4, IL-12 and TNF-α in the intestines. In addition, SBT pulp oil can promote the production of short fatty acids (SCFAs), increase the diversity of gut microbiota, improve the composition of intestinal flora, increase the abundance of
Alistipes
,
Bacteroide
s,
Anaerotruncus
,
Lactobacillus
,
ASF356
, and
Roseburia
, while decreasing the abundance of
Mucispirillum, Anaeroplasma, Pelagibacterium, Brevundimonas, Ochrobactrum, Acinetobacter, Ruminiclostridium, Blautia, Ruminiclostridium, Oscillibacter
, and
Faecalibaculum
. This study shows that SBT pulp oil can regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive Balb/c mice, thus enhancing the intestinal mucosa and systemic immune response. The results can provide a basis for understanding the function of SBT pulp oil and its application as a new probiotic and immunomodulator.
This study shows that SBT pulp oil can promote the concentrations of SCFAs and regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive BALB/c mice, thus enhancing the intestinal mucosa and systemic immune functions.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34251375</pmid><doi>10.1039/d1fo01257f</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2260-8506</orcidid></addata></record> |
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| ispartof | Food & function, 2021-09, Vol.12 (17), p.7954-7963 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Abundance Animals Body weight Composition Cyclophosphamide Cyclophosphamide - adverse effects Cytotoxicity Fatty acids Female Flora Gastrointestinal Microbiome - drug effects Hippophae - chemistry Humans Immune response Immune system Immunocompromised Host - drug effects Immunoglobulin A Immunomodulating Agents - administration & dosage Immunomodulation Immunomodulators Immunosuppressive Agents - adverse effects Inflammation - drug therapy Inflammation - etiology Inflammation - immunology Interleukin 12 Interleukin 2 Interleukin 4 Intestinal microflora Intestinal Mucosa - drug effects Intestinal Mucosa - microbiology Intestine Lymph nodes Lymphocytes Lymphocytes T Macrophages Mice Mice, Inbred BALB C Microbiota Mucosa Oil Phagocytosis Plant Oils - administration & dosage Probiotics Spleen Toxicity Tumor necrosis factor-α γ-Interferon |
| title | The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice |
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