Nifuroxazide mitigates cholestatic liver injury by synergistic inhibition of Il-6/Β-catenin signaling and enhancement of BSEP and MDRP 2 expression

Cholestasis is a complex hepatic disorder underlined with retention of the highly toxic bile components within the hepatocytes. Nifuroxazide (NIF); a nitrofuran derivative, is widely used drug for treatment of acute and chronic diarrhea. The current study was performed to investigate the curative ef...

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Veröffentlicht in:	International immunopharmacology 2021-10, Vol.99, p.107931
Hauptverfasser:	Nazmy, Entsar A, Helal, Manar G, Said, Eman
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals ATP Binding Cassette Transporter, Subfamily B, Member 11 - metabolism beta Catenin - metabolism Bile Bile Acids and Salts - metabolism Cholestasis - metabolism Hepatocytes - drug effects Humans Hydroxybenzoates - chemistry Hydroxybenzoates - pharmacology Interleukin-6 - metabolism Liver Liver Diseases - metabolism Male Mice Models, Molecular Molecular Docking Simulation Nitrofurans - chemistry Nitrofurans - pharmacology Protein Binding
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