Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

Porphyrinogenic compounds are known to induce porphyria-mediated hepatocellular injury and subsequent regenerative proliferation in rodents, ultimately leading to hepatocellular tumor induction. However, an appropriate in vivo experimental model to evaluate an effect of porphyrinogenic compounds on...

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Veröffentlicht in:	Toxicologic pathology 2021-10, Vol.49 (7), p.1243-1254
Hauptverfasser:	Eguchi, Ayumi, Fukunaga, Satoki, Ogata, Keiko, Kushida, Masahiko, Asano, Hiroyuki, Cohen, Samuel M., Sukata, Tokuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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