Effect of herbal medicine daikenchuto on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: A prospective randomized study
We conducted a prospective randomized study to investigate the effect of daikenchuto (DKT) on abdominal symptoms following laparoscopic colectomy in patients with left-sided colon cancer. Patients who suffered from abdominal pain or distention on postoperative day 1 were randomized to either the DKT...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2021-09, Vol.141, p.111887-111887, Article 111887 |
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| creator | Hanada, Keita Wada, Toshiaki Kawada, Kenji Hoshino, Nobuaki Okamoto, Michio Hirata, Wataru Mizuno, Rei Itatani, Yoshiro Inamoto, Susumu Takahashi, Ryo Yoshitomi, Mami Watanabe, Takeshi Hida, Koya Obama, Kazutaka Sakai, Yoshiharu |
| description | We conducted a prospective randomized study to investigate the effect of daikenchuto (DKT) on abdominal symptoms following laparoscopic colectomy in patients with left-sided colon cancer. Patients who suffered from abdominal pain or distention on postoperative day 1 were randomized to either the DKT group or non-DKT group. The primary endpoints were the evaluation of abdominal pain, abdominal distention, and quality of life. The metabolome and gut microbiome analyses were conducted as secondary endpoints. A total of 17 patients were enrolled: 8 patients in the DKT group and 9 patients in the non-DKT group. There were no significant differences in the primary endpoints and postoperative adverse events between the two groups. The metabolome and gut microbiome analyses showed that the levels of plasma lipid mediators associated with the arachidonic acid cascade were lower in the DKT group than in the non-DKT group, and that the relative abundance of genera Serratia and Bilophila were lower in the DKT group than in the non-DKT group. DKT administration did not improve the abdominal symptoms following laparoscopic colectomy. The effects of DKT on metabolites and gut microbiome have to be further investigated.
[Display omitted]
•This is a prospective randomized trial to examine the postoperative effect of DKT.•DKT intake did not improve the abdominal symptoms following laparoscopic colectomy.•We analyzed the plasma and fecal metabolites as well as the gut microbiome.•Plasma lipid mediators associated with arachidonic acid are lower in the DKT group.•The relative abundance of genera Serratia and Bilophila were lower in the DKT group. |
| doi_str_mv | 10.1016/j.biopha.2021.111887 |
| format | Article |
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[Display omitted]
•This is a prospective randomized trial to examine the postoperative effect of DKT.•DKT intake did not improve the abdominal symptoms following laparoscopic colectomy.•We analyzed the plasma and fecal metabolites as well as the gut microbiome.•Plasma lipid mediators associated with arachidonic acid are lower in the DKT group.•The relative abundance of genera Serratia and Bilophila were lower in the DKT group.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2021.111887</identifier><identifier>PMID: 34237597</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Aged ; Colectomy - methods ; Colectomy - trends ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - physiopathology ; Colonic Neoplasms - surgery ; Daikenchuto ; Female ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - physiopathology ; Gastrointestinal Diseases - surgery ; Gastrointestinal Microbiome - physiology ; Gut microbiome ; Herbal Medicine - methods ; Herbal Medicine - trends ; Humans ; Laparoscopic colectomy ; Laparoscopy - methods ; Laparoscopy - trends ; Male ; Metabolome ; Middle Aged ; Panax ; Plant Extracts - administration & dosage ; Postoperative gastrointestinal symptoms ; Prospective Studies ; TJ-100 ; Zanthoxylum ; Zingiberaceae</subject><ispartof>Biomedicine & pharmacotherapy, 2021-09, Vol.141, p.111887-111887, Article 111887</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-e3818aa601bb28f21c80953f36d2657ba9c7b2d3b527eb7cf040347b3e4e66993</citedby><cites>FETCH-LOGICAL-c452t-e3818aa601bb28f21c80953f36d2657ba9c7b2d3b527eb7cf040347b3e4e66993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2021.111887$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34237597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanada, Keita</creatorcontrib><creatorcontrib>Wada, Toshiaki</creatorcontrib><creatorcontrib>Kawada, Kenji</creatorcontrib><creatorcontrib>Hoshino, Nobuaki</creatorcontrib><creatorcontrib>Okamoto, Michio</creatorcontrib><creatorcontrib>Hirata, Wataru</creatorcontrib><creatorcontrib>Mizuno, Rei</creatorcontrib><creatorcontrib>Itatani, Yoshiro</creatorcontrib><creatorcontrib>Inamoto, Susumu</creatorcontrib><creatorcontrib>Takahashi, Ryo</creatorcontrib><creatorcontrib>Yoshitomi, Mami</creatorcontrib><creatorcontrib>Watanabe, Takeshi</creatorcontrib><creatorcontrib>Hida, Koya</creatorcontrib><creatorcontrib>Obama, Kazutaka</creatorcontrib><creatorcontrib>Sakai, Yoshiharu</creatorcontrib><title>Effect of herbal medicine daikenchuto on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: A prospective randomized study</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>We conducted a prospective randomized study to investigate the effect of daikenchuto (DKT) on abdominal symptoms following laparoscopic colectomy in patients with left-sided colon cancer. Patients who suffered from abdominal pain or distention on postoperative day 1 were randomized to either the DKT group or non-DKT group. The primary endpoints were the evaluation of abdominal pain, abdominal distention, and quality of life. The metabolome and gut microbiome analyses were conducted as secondary endpoints. A total of 17 patients were enrolled: 8 patients in the DKT group and 9 patients in the non-DKT group. There were no significant differences in the primary endpoints and postoperative adverse events between the two groups. The metabolome and gut microbiome analyses showed that the levels of plasma lipid mediators associated with the arachidonic acid cascade were lower in the DKT group than in the non-DKT group, and that the relative abundance of genera Serratia and Bilophila were lower in the DKT group than in the non-DKT group. DKT administration did not improve the abdominal symptoms following laparoscopic colectomy. The effects of DKT on metabolites and gut microbiome have to be further investigated.
[Display omitted]
•This is a prospective randomized trial to examine the postoperative effect of DKT.•DKT intake did not improve the abdominal symptoms following laparoscopic colectomy.•We analyzed the plasma and fecal metabolites as well as the gut microbiome.•Plasma lipid mediators associated with arachidonic acid are lower in the DKT group.•The relative abundance of genera Serratia and Bilophila were lower in the DKT group.</description><subject>Aged</subject><subject>Colectomy - methods</subject><subject>Colectomy - trends</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - physiopathology</subject><subject>Colonic Neoplasms - surgery</subject><subject>Daikenchuto</subject><subject>Female</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Gastrointestinal Diseases - surgery</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gut microbiome</subject><subject>Herbal Medicine - methods</subject><subject>Herbal Medicine - trends</subject><subject>Humans</subject><subject>Laparoscopic colectomy</subject><subject>Laparoscopy - methods</subject><subject>Laparoscopy - trends</subject><subject>Male</subject><subject>Metabolome</subject><subject>Middle Aged</subject><subject>Panax</subject><subject>Plant Extracts - administration & dosage</subject><subject>Postoperative gastrointestinal symptoms</subject><subject>Prospective Studies</subject><subject>TJ-100</subject><subject>Zanthoxylum</subject><subject>Zingiberaceae</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhDRDykk0G_8RxwgKpqsqPVIkNrC3bue54SOxgO62Gt-FN8SiFJSsv_J1z7z0HodeU7Cmh3bvj3vi4HPSeEUb3lNK-l0_Qjg6CNB0h8inaESl4wzljF-hFzkdCiOh4_xxd8JZxKQa5Q79vnANbcHT4AMnoCc8weusD4FH7HxDsYS0Rx4DvdC4p-lAgFx8qmE_zUuKcsYvTFB98uMOTXnSK2cbFW2zjVJ3jfMI-4EUXD6Fk_ODL4fxVHa0OFtJ7fIWXKloq7O8BJx3GOPtfMOJc1vH0Ej1zesrw6vG9RN8_3ny7_tzcfv305frqtrGtYKUB3tNe645QY1jvGLU9GQR3vBtZJ6TRg5WGjdwIJsFI60hLeCsNhxa6bhj4JXq7-dZlfq71SDX7bGGadIC4ZsWEIKxjnJKKthtq6945gVNL8rNOJ0WJOpejjmorR53LUVs5VfbmccJqasr_RH_bqMCHDYB6572HpLKtqdnaSKrpqDH6_0_4AxnApmo</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Hanada, Keita</creator><creator>Wada, Toshiaki</creator><creator>Kawada, Kenji</creator><creator>Hoshino, Nobuaki</creator><creator>Okamoto, Michio</creator><creator>Hirata, Wataru</creator><creator>Mizuno, Rei</creator><creator>Itatani, Yoshiro</creator><creator>Inamoto, Susumu</creator><creator>Takahashi, Ryo</creator><creator>Yoshitomi, Mami</creator><creator>Watanabe, Takeshi</creator><creator>Hida, Koya</creator><creator>Obama, Kazutaka</creator><creator>Sakai, Yoshiharu</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Effect of herbal medicine daikenchuto on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: A prospective randomized study</title><author>Hanada, Keita ; 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Patients who suffered from abdominal pain or distention on postoperative day 1 were randomized to either the DKT group or non-DKT group. The primary endpoints were the evaluation of abdominal pain, abdominal distention, and quality of life. The metabolome and gut microbiome analyses were conducted as secondary endpoints. A total of 17 patients were enrolled: 8 patients in the DKT group and 9 patients in the non-DKT group. There were no significant differences in the primary endpoints and postoperative adverse events between the two groups. The metabolome and gut microbiome analyses showed that the levels of plasma lipid mediators associated with the arachidonic acid cascade were lower in the DKT group than in the non-DKT group, and that the relative abundance of genera Serratia and Bilophila were lower in the DKT group than in the non-DKT group. DKT administration did not improve the abdominal symptoms following laparoscopic colectomy. The effects of DKT on metabolites and gut microbiome have to be further investigated.
[Display omitted]
•This is a prospective randomized trial to examine the postoperative effect of DKT.•DKT intake did not improve the abdominal symptoms following laparoscopic colectomy.•We analyzed the plasma and fecal metabolites as well as the gut microbiome.•Plasma lipid mediators associated with arachidonic acid are lower in the DKT group.•The relative abundance of genera Serratia and Bilophila were lower in the DKT group.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>34237597</pmid><doi>10.1016/j.biopha.2021.111887</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Colectomy - methods Colectomy - trends Colonic Neoplasms - drug therapy Colonic Neoplasms - physiopathology Colonic Neoplasms - surgery Daikenchuto Female Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - physiopathology Gastrointestinal Diseases - surgery Gastrointestinal Microbiome - physiology Gut microbiome Herbal Medicine - methods Herbal Medicine - trends Humans Laparoscopic colectomy Laparoscopy - methods Laparoscopy - trends Male Metabolome Middle Aged Panax Plant Extracts - administration & dosage Postoperative gastrointestinal symptoms Prospective Studies TJ-100 Zanthoxylum Zingiberaceae |
| title | Effect of herbal medicine daikenchuto on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: A prospective randomized study |
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