Latcripin-7A from Lentinula edodes C 91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling

Gastric cancer (G.C) is one of the most lethal cancer types worldwide. Current treatment requires surgery along with chemotherapy, which causes obstacles for speedy recovery. The discovery of novel drugs is needed for better treatment of G.C with minimum side effects. Latcripin-7A (LP-7A) is a newly...

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Veröffentlicht in:	European journal of pharmacology 2021-09, Vol.907, p.174305
Hauptverfasser:	Din, Syed Riaz Ud, Nisar, Muhammad Azhar, Ramzan, Muhammad Noman, Saleem, Muhammad Zubair, Ghayas, Hassan, Ahmad, Bashir, Batool, Samana, Kifayat, Kashif, Guo, Xiaorong, Huang, Min, Zhong, Mintao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Autophagy - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Fungal Proteins - pharmacology G1 Phase Cell Cycle Checkpoints - drug effects Humans Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Shiitake Mushrooms - chemistry Signal Transduction - drug effects Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology TOR Serine-Threonine Kinases - metabolism
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