Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)
Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase...
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| Veröffentlicht in: | Journal of medical biochemistry 2021-01, Vol.40 (3), p.286-294 |
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| creator | Aladağ, Nesim Asoğlu, Ramazan Ozdemir, Mahmut Asoğlu, Emin Derin, Atabey Rukiye Demir, Canan Demir, Halit |
| description | Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI.
The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography.
Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p |
| doi_str_mv | 10.5937/jomb0-28879 |
| format | Article |
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The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography.
Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p<0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p<0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p<0.001 MDA vs catalase; r = -0.821 p<0.001 SOD vs catalase).
Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels of MDA and IMA and decreased levels of SOD and catalase.]]></description><identifier>ISSN: 1452-8258</identifier><identifier>EISSN: 1452-8266</identifier><identifier>DOI: 10.5937/jomb0-28879</identifier><identifier>PMID: 34177373</identifier><language>eng</language><publisher>Serbia: Society of Medical Biochemists of Serbia, Belgrade</publisher><subject>catalase ; ischemia modified albumin ; malondialdehyde acid ; nstemi ; Original Paper ; stemi ; superoxide dismutase</subject><ispartof>Journal of medical biochemistry, 2021-01, Vol.40 (3), p.286-294</ispartof><rights>2021 Nesim Aladağ, Ramazan Asoğlu, Mahmut Ozdemir, Emin Asoğlu, Atabey Rukiye Derin, Canan Demir, Halit Demir, published by CEON/CEES.</rights><rights>2021 Nesim Aladağ, Ramazan Asoğlu, Mahmut Ozdemir, Emin Asoğlu, Atabey Rukiye Derin, Canan Demir, Halit Demir, published by CEON/CEES 2021 Society of Medical Biochemists of Serbia, Belgrade</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-a06a36720b4b9a4f457903f49b8ddab8e0270843ccc33b640bd6f72f8288693b3</citedby><cites>FETCH-LOGICAL-c447t-a06a36720b4b9a4f457903f49b8ddab8e0270843ccc33b640bd6f72f8288693b3</cites><orcidid>0000-0003-2346-1152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199596/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199596/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34177373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aladağ, Nesim</creatorcontrib><creatorcontrib>Asoğlu, Ramazan</creatorcontrib><creatorcontrib>Ozdemir, Mahmut</creatorcontrib><creatorcontrib>Asoğlu, Emin</creatorcontrib><creatorcontrib>Derin, Atabey Rukiye</creatorcontrib><creatorcontrib>Demir, Canan</creatorcontrib><creatorcontrib>Demir, Halit</creatorcontrib><title>Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)</title><title>Journal of medical biochemistry</title><addtitle>J Med Biochem</addtitle><description><![CDATA[Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI.
The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography.
Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p<0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p<0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p<0.001 MDA vs catalase; r = -0.821 p<0.001 SOD vs catalase).
Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels of MDA and IMA and decreased levels of SOD and catalase.]]></description><subject>catalase</subject><subject>ischemia modified albumin</subject><subject>malondialdehyde acid</subject><subject>nstemi</subject><subject>Original Paper</subject><subject>stemi</subject><subject>superoxide dismutase</subject><issn>1452-8258</issn><issn>1452-8266</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kk1v1DAQhiMEoqVw4o58XEQDTuzYMQckVBVYqdBDl7M1_siuV4m9jZNt949zxpttV_TAwbLnndfPjDSTZW8L_LEShH9ah07hvKxrLp5lpwWtyrwuGXt-fFf1SfYqxjXGVV0I_jI7IbTgnHBymv25vncG_BAReJPO4MKj4DzqdkFDbxy0KWqg1ynt0ezn_P1nNPdbGwe3hEkLDXJRr2znAHXBuMbZhGvV2Dl_jjpog99jjF3tjD1HcdzYfl_JIuNiNw4Q7dSBhgHafZCqu_Rl68wIbUwuWPoQE_TODSt0s0C2tVsYkvCfJm8Wl6nPCeqDz6cQzX4d5NfZiyZh7ZuH-yz7_e1ycfEjv7r-Pr_4epVrSvmQA2ZAGC-xokoAbWjFBSYNFao2BlRtcclxTYnWmhDFKFaGNbxs6jQNJogiZ9n8wDUB1nLTuw76nQzg5CSEfimhH5xurbQVVqwQjEFV0JLVqhFNImPNeZIoT6wvB9ZmVJ012vqhh_YJ9GnGu5Vchq1MQxeVYAkwewD04XZMw5NdmpltW_A2jFGWFa2EwIyVyfrhYNV9iLG3zbFMgeV-6-S0dXLauuR-929nR-_jmpG_MQ_YMA</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Aladağ, Nesim</creator><creator>Asoğlu, Ramazan</creator><creator>Ozdemir, Mahmut</creator><creator>Asoğlu, Emin</creator><creator>Derin, Atabey Rukiye</creator><creator>Demir, Canan</creator><creator>Demir, Halit</creator><general>Society of Medical Biochemists of Serbia, Belgrade</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2346-1152</orcidid></search><sort><creationdate>20210101</creationdate><title>Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)</title><author>Aladağ, Nesim ; Asoğlu, Ramazan ; Ozdemir, Mahmut ; Asoğlu, Emin ; Derin, Atabey Rukiye ; Demir, Canan ; Demir, Halit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-a06a36720b4b9a4f457903f49b8ddab8e0270843ccc33b640bd6f72f8288693b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>catalase</topic><topic>ischemia modified albumin</topic><topic>malondialdehyde acid</topic><topic>nstemi</topic><topic>Original Paper</topic><topic>stemi</topic><topic>superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aladağ, Nesim</creatorcontrib><creatorcontrib>Asoğlu, Ramazan</creatorcontrib><creatorcontrib>Ozdemir, Mahmut</creatorcontrib><creatorcontrib>Asoğlu, Emin</creatorcontrib><creatorcontrib>Derin, Atabey Rukiye</creatorcontrib><creatorcontrib>Demir, Canan</creatorcontrib><creatorcontrib>Demir, Halit</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of medical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aladağ, Nesim</au><au>Asoğlu, Ramazan</au><au>Ozdemir, Mahmut</au><au>Asoğlu, Emin</au><au>Derin, Atabey Rukiye</au><au>Demir, Canan</au><au>Demir, Halit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)</atitle><jtitle>Journal of medical biochemistry</jtitle><addtitle>J Med Biochem</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>40</volume><issue>3</issue><spage>286</spage><epage>294</epage><pages>286-294</pages><issn>1452-8258</issn><eissn>1452-8266</eissn><abstract><![CDATA[Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI.
The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography.
Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p<0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p<0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p<0.001 MDA vs catalase; r = -0.821 p<0.001 SOD vs catalase).
Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels of MDA and IMA and decreased levels of SOD and catalase.]]></abstract><cop>Serbia</cop><pub>Society of Medical Biochemists of Serbia, Belgrade</pub><pmid>34177373</pmid><doi>10.5937/jomb0-28879</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2346-1152</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | catalase ischemia modified albumin malondialdehyde acid nstemi Original Paper stemi superoxide dismutase |
| title | Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) |
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