Superoxide dismutase nanozymes: an emerging star for anti-oxidation
Superoxide dismutases (SODs) are a group of metalloenzymes that catalyze the dismutation of superoxide radicals (O 2 &z.rad; − ) into hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 ). As the first line of defense against reactive oxygen species (ROS)-mediated damage, SODs are expected to play an i...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-09, Vol.9 (35), p.6939-6957 |
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| creator | Zhao, Hanqing Zhang, Ruofei Yan, Xiyun Fan, Kelong |
| description | Superoxide dismutases (SODs) are a group of metalloenzymes that catalyze the dismutation of superoxide radicals (O
2
&z.rad;
−
) into hydrogen peroxide (H
2
O
2
) and oxygen (O
2
). As the first line of defense against reactive oxygen species (ROS)-mediated damage, SODs are expected to play an important role in the treatment of oxidative stress-related diseases. However, the clinical applications of SODs have been severely limited by their structural instability and high cost. Compared with natural enzymes, nanozymes, nanomaterials with enzyme-like activity, are more stable, and economical, can be easily modified and their activities can be adjusted. Due to their excellent characteristics, nanozymes have attracted widespread attention in recent years and are expected to become effective substitutes for natural enzymes in many application fields. Importantly, some nanozymes with SOD-like activity have been developed and proved to have a mitigating effect on diseases caused by oxidative stress. These studies on SOD-like nanozymes provide a feasible strategy for breaking through the dilemma of SOD clinical applications. However, at present, the specific catalytic mechanism of SOD-like nanozymes is still unclear, and many important issues need to be resolved. Although there are many comprehensive reviews to introduce the overall situation of the nanozyme field, the research on SOD-like nanozymes still lacks a systematic review. From the structure and mechanism of natural SOD enzymes to the structure and regulation of SOD-like nanozymes, and then to the measurement and application of nanozymes, this review systematically summarizes the recent progress in SOD-like nanozymes. The existing shortcomings and possible future research hotspots in the development of SOD-like nanozymes are summarized and prospected. We hope that this review would provide ideas and inspirations for further research on the catalytic mechanism and rational design of SOD-like nanozymes.
This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well as proposes the current challenges and prospects in the development of SOD-like nanozymes. |
| doi_str_mv | 10.1039/d1tb00720c |
| format | Article |
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2
&z.rad;
−
) into hydrogen peroxide (H
2
O
2
) and oxygen (O
2
). As the first line of defense against reactive oxygen species (ROS)-mediated damage, SODs are expected to play an important role in the treatment of oxidative stress-related diseases. However, the clinical applications of SODs have been severely limited by their structural instability and high cost. Compared with natural enzymes, nanozymes, nanomaterials with enzyme-like activity, are more stable, and economical, can be easily modified and their activities can be adjusted. Due to their excellent characteristics, nanozymes have attracted widespread attention in recent years and are expected to become effective substitutes for natural enzymes in many application fields. Importantly, some nanozymes with SOD-like activity have been developed and proved to have a mitigating effect on diseases caused by oxidative stress. These studies on SOD-like nanozymes provide a feasible strategy for breaking through the dilemma of SOD clinical applications. However, at present, the specific catalytic mechanism of SOD-like nanozymes is still unclear, and many important issues need to be resolved. Although there are many comprehensive reviews to introduce the overall situation of the nanozyme field, the research on SOD-like nanozymes still lacks a systematic review. From the structure and mechanism of natural SOD enzymes to the structure and regulation of SOD-like nanozymes, and then to the measurement and application of nanozymes, this review systematically summarizes the recent progress in SOD-like nanozymes. The existing shortcomings and possible future research hotspots in the development of SOD-like nanozymes are summarized and prospected. We hope that this review would provide ideas and inspirations for further research on the catalytic mechanism and rational design of SOD-like nanozymes.
This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well as proposes the current challenges and prospects in the development of SOD-like nanozymes.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d1tb00720c</identifier><identifier>PMID: 34161407</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Antioxidants - chemistry ; Antioxidants - metabolism ; Biocompatible Materials - chemistry ; Biocompatible Materials - metabolism ; Enzymes ; Humans ; Hydrogen peroxide ; Materials Testing ; Nanomaterials ; Nanotechnology ; Oxidation ; Oxidative stress ; Reactive oxygen species ; Reviews ; Structural stability ; Superoxide dismutase ; Superoxide Dismutase - chemistry ; Superoxide Dismutase - metabolism ; Therapeutic applications</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2021-09, Vol.9 (35), p.6939-6957</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-3c03f1e7da1b3651ffbd7184f582084ffbebf2518d8a9a68c3655601bb8908413</citedby><cites>FETCH-LOGICAL-c414t-3c03f1e7da1b3651ffbd7184f582084ffbebf2518d8a9a68c3655601bb8908413</cites><orcidid>0000-0001-6285-1933</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34161407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Hanqing</creatorcontrib><creatorcontrib>Zhang, Ruofei</creatorcontrib><creatorcontrib>Yan, Xiyun</creatorcontrib><creatorcontrib>Fan, Kelong</creatorcontrib><title>Superoxide dismutase nanozymes: an emerging star for anti-oxidation</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Superoxide dismutases (SODs) are a group of metalloenzymes that catalyze the dismutation of superoxide radicals (O
2
&z.rad;
−
) into hydrogen peroxide (H
2
O
2
) and oxygen (O
2
). As the first line of defense against reactive oxygen species (ROS)-mediated damage, SODs are expected to play an important role in the treatment of oxidative stress-related diseases. However, the clinical applications of SODs have been severely limited by their structural instability and high cost. Compared with natural enzymes, nanozymes, nanomaterials with enzyme-like activity, are more stable, and economical, can be easily modified and their activities can be adjusted. Due to their excellent characteristics, nanozymes have attracted widespread attention in recent years and are expected to become effective substitutes for natural enzymes in many application fields. Importantly, some nanozymes with SOD-like activity have been developed and proved to have a mitigating effect on diseases caused by oxidative stress. These studies on SOD-like nanozymes provide a feasible strategy for breaking through the dilemma of SOD clinical applications. However, at present, the specific catalytic mechanism of SOD-like nanozymes is still unclear, and many important issues need to be resolved. Although there are many comprehensive reviews to introduce the overall situation of the nanozyme field, the research on SOD-like nanozymes still lacks a systematic review. From the structure and mechanism of natural SOD enzymes to the structure and regulation of SOD-like nanozymes, and then to the measurement and application of nanozymes, this review systematically summarizes the recent progress in SOD-like nanozymes. The existing shortcomings and possible future research hotspots in the development of SOD-like nanozymes are summarized and prospected. We hope that this review would provide ideas and inspirations for further research on the catalytic mechanism and rational design of SOD-like nanozymes.
This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well as proposes the current challenges and prospects in the development of SOD-like nanozymes.</description><subject>Animals</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - metabolism</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - metabolism</subject><subject>Enzymes</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Materials Testing</subject><subject>Nanomaterials</subject><subject>Nanotechnology</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Reactive oxygen species</subject><subject>Reviews</subject><subject>Structural stability</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - chemistry</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Therapeutic applications</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1LwzAUAPAgihtzF-9KwYsI1bwmbTJvWj9h4MEJ3krSJqNjbWaSgvOvN3Vzgrm8kPfLy-MFoWPAl4DJ5KoCLzFmCS730DDBKY5ZCnx_t8fvAzR2boHD4pBxQg_RgFDIgGI2RPlrt1LWfNaViqraNZ0XTkWtaM3XulHuOhJtpBpl53U7j5wXNtLGhkNfx_0l4WvTHqEDLZZOjbdxhN4e7mf5Uzx9eXzOb6ZxSYH6mJSYaFCsEiBJloLWsmLAqU55gkPQUkmdhOYrLiYi42VAaYZBSj4JeSAjdL6pu7Lmo1POF03tSrVcilaZzhVJSilnnLOenv2jC9PZNnQXFEvS8ArPgrrYqNIa56zSxcrWjbDrAnDRT7e4g9ntz3TzgE-3JTvZqGpHf2cZwMkGWFfusn_fQ74Bmzx9LA</recordid><startdate>20210915</startdate><enddate>20210915</enddate><creator>Zhao, Hanqing</creator><creator>Zhang, Ruofei</creator><creator>Yan, Xiyun</creator><creator>Fan, Kelong</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6285-1933</orcidid></search><sort><creationdate>20210915</creationdate><title>Superoxide dismutase nanozymes: an emerging star for anti-oxidation</title><author>Zhao, Hanqing ; Zhang, Ruofei ; Yan, Xiyun ; Fan, Kelong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-3c03f1e7da1b3651ffbd7184f582084ffbebf2518d8a9a68c3655601bb8908413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - metabolism</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - metabolism</topic><topic>Enzymes</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Materials Testing</topic><topic>Nanomaterials</topic><topic>Nanotechnology</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Reactive oxygen species</topic><topic>Reviews</topic><topic>Structural stability</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - chemistry</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Hanqing</creatorcontrib><creatorcontrib>Zhang, Ruofei</creatorcontrib><creatorcontrib>Yan, Xiyun</creatorcontrib><creatorcontrib>Fan, Kelong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Hanqing</au><au>Zhang, Ruofei</au><au>Yan, Xiyun</au><au>Fan, Kelong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superoxide dismutase nanozymes: an emerging star for anti-oxidation</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2021-09-15</date><risdate>2021</risdate><volume>9</volume><issue>35</issue><spage>6939</spage><epage>6957</epage><pages>6939-6957</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Superoxide dismutases (SODs) are a group of metalloenzymes that catalyze the dismutation of superoxide radicals (O
2
&z.rad;
−
) into hydrogen peroxide (H
2
O
2
) and oxygen (O
2
). As the first line of defense against reactive oxygen species (ROS)-mediated damage, SODs are expected to play an important role in the treatment of oxidative stress-related diseases. However, the clinical applications of SODs have been severely limited by their structural instability and high cost. Compared with natural enzymes, nanozymes, nanomaterials with enzyme-like activity, are more stable, and economical, can be easily modified and their activities can be adjusted. Due to their excellent characteristics, nanozymes have attracted widespread attention in recent years and are expected to become effective substitutes for natural enzymes in many application fields. Importantly, some nanozymes with SOD-like activity have been developed and proved to have a mitigating effect on diseases caused by oxidative stress. These studies on SOD-like nanozymes provide a feasible strategy for breaking through the dilemma of SOD clinical applications. However, at present, the specific catalytic mechanism of SOD-like nanozymes is still unclear, and many important issues need to be resolved. Although there are many comprehensive reviews to introduce the overall situation of the nanozyme field, the research on SOD-like nanozymes still lacks a systematic review. From the structure and mechanism of natural SOD enzymes to the structure and regulation of SOD-like nanozymes, and then to the measurement and application of nanozymes, this review systematically summarizes the recent progress in SOD-like nanozymes. The existing shortcomings and possible future research hotspots in the development of SOD-like nanozymes are summarized and prospected. We hope that this review would provide ideas and inspirations for further research on the catalytic mechanism and rational design of SOD-like nanozymes.
This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well as proposes the current challenges and prospects in the development of SOD-like nanozymes.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34161407</pmid><doi>10.1039/d1tb00720c</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0001-6285-1933</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2021-09, Vol.9 (35), p.6939-6957 |
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| source | MEDLINE; Royal Society Of Chemistry Journals |
| subjects | Animals Antioxidants - chemistry Antioxidants - metabolism Biocompatible Materials - chemistry Biocompatible Materials - metabolism Enzymes Humans Hydrogen peroxide Materials Testing Nanomaterials Nanotechnology Oxidation Oxidative stress Reactive oxygen species Reviews Structural stability Superoxide dismutase Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism Therapeutic applications |
| title | Superoxide dismutase nanozymes: an emerging star for anti-oxidation |
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