Experimental design of preclinical experiments: number of PDX lines vs subsampling within PDX lines

Abstract Background Appropriately designed preclinical patient-derived xenograft (PDX) experiments are important to accurately inform human clinical trials. There is little experimental design guidance regarding choosing the number of PDX lines to study, and the number of mice within each PDX line....

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2021-12, Vol.23 (12), p.2066-2075
Hauptverfasser:	Eckel-Passow, Jeanette E, Kitange, Gaspar J, Decker, Paul A, Kosel, Matthew L, Burgenske, Danielle M, Oberg, Ann L, Sarkaria, Jann N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic and Translational Investigations Brain Neoplasms Cell Line, Tumor Clinical Neurology Glioblastoma Life Sciences & Biomedicine Mice Neurosciences & Neurology Oncology Research Design Retrospective Studies Science & Technology Temozolomide Xenograft Model Antitumor Assays
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