CD34+ derived macrophage and dendritic cells display differential responses to paraquat

Paraquat (PQ) is a redox cycling herbicide known for its acute toxicity in humans. Airway parenchymal cells have been identified as primary sites for PQ accumulation, tissue inflammation and cellular injury. However, the role of immune cells in PQ induced tissue injury is largely unknown. To explore...

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Veröffentlicht in:	Toxicology in vitro 2021-09, Vol.75, p.105198, Article 105198
Hauptverfasser:	Fransen, Leonie F.H., Leonard, Martin O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Allergens Allergens - administration & dosage Animals Antigens, CD34 - immunology Bioaccumulation CD34 antigen Cell Survival - drug effects Cellular stress response Cytotoxicity Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Genes Herbicides Herbicides - toxicity House dust Humans Immune system Inflammation Inflammatory diseases Life Sciences & Biomedicine Lung Macrophages Macrophages - drug effects Macrophages - immunology Myeloid NF-κB protein p53 Protein Paraquat Paraquat - toxicity Protein folding Pyroglyphidae - immunology Redox properties Science & Technology Stem cells TempO-Seq Toxicity Toxicology Transcriptomics
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