Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010
Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors. University Hospital Río Hortega. New prostate cancer diagnoses. Incide...
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| Veröffentlicht in: | Actas urológicas españolas (English ed.) 2021-06, Vol.45 (5), p.383 |
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| creator | Gutiérrez-Pérez, M I González-Sagrado, M Conde-Vicente, R Amón-Sesmero, J H |
| description | Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors.
University Hospital Río Hortega.
New prostate cancer diagnoses.
Incidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D'Amico groups.
Castilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences in |
| format | Article |
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University Hospital Río Hortega.
New prostate cancer diagnoses.
Incidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D'Amico groups.
Castilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences in < 64 and 65-74 years. Age at diagnosis was the lowest (Castilla y León, 66.9 ±7.1 vs. Spain, 69.1 ± 8.2 years; P < .001). No differences: family history, symptoms, comorbidity and PSA. The number of cylinders was 10.7 ± 1.8. In multivariate analysis (AUC = 0.801; P < .001), they were more frequent in Castilla y León: grade i rectal examination, non-palpable rectal examination, Gleason < 6, stage T2c and the volume cylinder ratio < 6 (only in < 64 years: OR 5.2; 95% CI 1.2-22-22.3; P = .027). In Spanish regions, volume cylinder ratio showed inverse correlation with IR in < 74 years, while age showed positive correlation in all age groups.
The higher prostate cancer IR in Castilla y León in 2010 was not associated to an older population. However, the biopsy technique influenced IR, as more cylinders were obtained in younger subjects, without conditioning overdiagnosis.]]></description><identifier>EISSN: 2173-5786</identifier><identifier>PMID: 34088438</identifier><language>eng</language><publisher>Spain</publisher><subject>Cross-Sectional Studies ; Humans ; Incidence ; Male ; Observational Studies as Topic ; Prostatic Neoplasms - diagnosis ; Registries ; Spain - epidemiology</subject><ispartof>Actas urológicas españolas (English ed.), 2021-06, Vol.45 (5), p.383</ispartof><rights>Copyright © 2021 AEU. Published by Elsevier España, S.L.U. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34088438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gutiérrez-Pérez, M I</creatorcontrib><creatorcontrib>González-Sagrado, M</creatorcontrib><creatorcontrib>Conde-Vicente, R</creatorcontrib><creatorcontrib>Amón-Sesmero, J H</creatorcontrib><title>Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010</title><title>Actas urológicas españolas (English ed.)</title><addtitle>Actas Urol Esp (Engl Ed)</addtitle><description><![CDATA[Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors.
University Hospital Río Hortega.
New prostate cancer diagnoses.
Incidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D'Amico groups.
Castilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences in < 64 and 65-74 years. Age at diagnosis was the lowest (Castilla y León, 66.9 ±7.1 vs. Spain, 69.1 ± 8.2 years; P < .001). No differences: family history, symptoms, comorbidity and PSA. The number of cylinders was 10.7 ± 1.8. In multivariate analysis (AUC = 0.801; P < .001), they were more frequent in Castilla y León: grade i rectal examination, non-palpable rectal examination, Gleason < 6, stage T2c and the volume cylinder ratio < 6 (only in < 64 years: OR 5.2; 95% CI 1.2-22-22.3; P = .027). In Spanish regions, volume cylinder ratio showed inverse correlation with IR in < 74 years, while age showed positive correlation in all age groups.
The higher prostate cancer IR in Castilla y León in 2010 was not associated to an older population. However, the biopsy technique influenced IR, as more cylinders were obtained in younger subjects, without conditioning overdiagnosis.]]></description><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Observational Studies as Topic</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Registries</subject><subject>Spain - epidemiology</subject><issn>2173-5786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFj0FqwzAQRUWg1KH1FcJcIOBEju2sTUMDWXYfppLsTpBHRlIWvkQvkyP0YlFMu-7fDHzePPgLsdxuarne1U2ViTyES5FSlXK3l88ik2XRNKVsluL7yJ29GlYGXAfxy4Am7NmFSApG76JTzgKyBuwTwjOS-hAxGlCYHj0QK9Kzwz9aYmgxCaxFmOBkfm4MqJTzmriH6GYHYyTHaMGbnkL0E2yLTfEqnjq0weS_90WsDm8f7ft6vH4ORp9HTwP66fw3QP4L3AFgKVOa</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Gutiérrez-Pérez, M I</creator><creator>González-Sagrado, M</creator><creator>Conde-Vicente, R</creator><creator>Amón-Sesmero, J H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202106</creationdate><title>Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010</title><author>Gutiérrez-Pérez, M I ; González-Sagrado, M ; Conde-Vicente, R ; Amón-Sesmero, J H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_340884383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Observational Studies as Topic</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Registries</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gutiérrez-Pérez, M I</creatorcontrib><creatorcontrib>González-Sagrado, M</creatorcontrib><creatorcontrib>Conde-Vicente, R</creatorcontrib><creatorcontrib>Amón-Sesmero, J H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Actas urológicas españolas (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gutiérrez-Pérez, M I</au><au>González-Sagrado, M</au><au>Conde-Vicente, R</au><au>Amón-Sesmero, J H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010</atitle><jtitle>Actas urológicas españolas (English ed.)</jtitle><addtitle>Actas Urol Esp (Engl Ed)</addtitle><date>2021-06</date><risdate>2021</risdate><volume>45</volume><issue>5</issue><spage>383</spage><pages>383-</pages><eissn>2173-5786</eissn><abstract><![CDATA[Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors.
University Hospital Río Hortega.
New prostate cancer diagnoses.
Incidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D'Amico groups.
Castilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences in < 64 and 65-74 years. Age at diagnosis was the lowest (Castilla y León, 66.9 ±7.1 vs. Spain, 69.1 ± 8.2 years; P < .001). No differences: family history, symptoms, comorbidity and PSA. The number of cylinders was 10.7 ± 1.8. In multivariate analysis (AUC = 0.801; P < .001), they were more frequent in Castilla y León: grade i rectal examination, non-palpable rectal examination, Gleason < 6, stage T2c and the volume cylinder ratio < 6 (only in < 64 years: OR 5.2; 95% CI 1.2-22-22.3; P = .027). In Spanish regions, volume cylinder ratio showed inverse correlation with IR in < 74 years, while age showed positive correlation in all age groups.
The higher prostate cancer IR in Castilla y León in 2010 was not associated to an older population. However, the biopsy technique influenced IR, as more cylinders were obtained in younger subjects, without conditioning overdiagnosis.]]></abstract><cop>Spain</cop><pmid>34088438</pmid></addata></record> |
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| identifier | EISSN: 2173-5786 |
| ispartof | Actas urológicas españolas (English ed.), 2021-06, Vol.45 (5), p.383 |
| issn | 2173-5786 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Cross-Sectional Studies Humans Incidence Male Observational Studies as Topic Prostatic Neoplasms - diagnosis Registries Spain - epidemiology |
| title | Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010 |
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