Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping
Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-06, Vol.9 (24), p.4857-4862 |
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| creator | Elbatrawy, Ahmed A Lee, Da Sol Lee, Sang Bong Jeon, Hui-Jeon Lee, Sijoon Kang, Kyung-ku Sung, Soo-Eun Han, Ye Ri Cho, Sung Jin Kim, Dong-Su Kim, Kil Soo Nam, Ghilsoo Jeon, Yong Hyun |
| description | Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.
In vivo
fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without
in vivo
toxicity, which was consistent with the findings of
ex vivo
imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.
A novel near-infrared fluorescent imaging probe, KSNP117, was developed. Its excellent stability and biocompatibility were confirmed
in vitro
and
in vivo
, and its biomedical application for sentinel lymph node mapping was successfully demonstrated. |
| doi_str_mv | 10.1039/d1tb00568e |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_34076031</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2536479221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-b32d76e16f807b67a0ae0e055e251906065cbb830cdb5e00add400bc583dac203</originalsourceid><addsrcrecordid>eNpd0c1LwzAYBvAgihPdxbsS8CKy6pumSbujH_MDRQUneBBK0rzVStvUZBX23xudTjCXBPLLy8MTQrYZHDLg4yPDZhpAyAxXyEYMAqJUsGx1eYanARl6_wZhZUxmPFknA55AKoGzDfJ8az-wpu991dq6ajHSyqOhZd1bh77AdkZ1ZatGvVTtC-2c1Tii1w-394ylI1paR30w4WFN63nTvdLWGqSN6rrgt8haqWqPw599kzyeT6anl9HN3cXV6fFNVHCeziLNY5NKZLLMINUyVaAQEITAWLAxSJCi0DrjUBgtEEAZkwDoQmTcqCIGvkn2F3NDvvce_SxvqpC9rlWLtvd5LLhM0nEcs0D3_tE327s2pAsqSVgmhIyDOliowlnvHZZ550IHbp4zyL9qz8_Y9OS79knAuz8je92gWdLfkgPYWQDni-Xt37_xTxobhXU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2544185562</pqid></control><display><type>article</type><title>Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Elbatrawy, Ahmed A ; Lee, Da Sol ; Lee, Sang Bong ; Jeon, Hui-Jeon ; Lee, Sijoon ; Kang, Kyung-ku ; Sung, Soo-Eun ; Han, Ye Ri ; Cho, Sung Jin ; Kim, Dong-Su ; Kim, Kil Soo ; Nam, Ghilsoo ; Jeon, Yong Hyun</creator><creatorcontrib>Elbatrawy, Ahmed A ; Lee, Da Sol ; Lee, Sang Bong ; Jeon, Hui-Jeon ; Lee, Sijoon ; Kang, Kyung-ku ; Sung, Soo-Eun ; Han, Ye Ri ; Cho, Sung Jin ; Kim, Dong-Su ; Kim, Kil Soo ; Nam, Ghilsoo ; Jeon, Yong Hyun</creatorcontrib><description>Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.
In vivo
fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without
in vivo
toxicity, which was consistent with the findings of
ex vivo
imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.
A novel near-infrared fluorescent imaging probe, KSNP117, was developed. Its excellent stability and biocompatibility were confirmed
in vitro
and
in vivo
, and its biomedical application for sentinel lymph node mapping was successfully demonstrated.</description><identifier>ISSN: 2050-750X</identifier><identifier>ISSN: 2050-7518</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d1tb00568e</identifier><identifier>PMID: 34076031</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Biocompatibility ; Biomedical materials ; Brightening ; Cell proliferation ; Cell Proliferation - drug effects ; Female ; Fluorescent Dyes - chemical synthesis ; Fluorescent Dyes - chemistry ; Fluorescent indicators ; Fluoroscopic imaging ; Humans ; Immune system ; Lymph nodes ; Medical imaging ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Optical Imaging ; Quinoline ; Quinolines - chemistry ; Sentinel Lymph Node - diagnostic imaging ; Sentinel Lymph Node - pathology ; Toxicity</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2021-06, Vol.9 (24), p.4857-4862</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-b32d76e16f807b67a0ae0e055e251906065cbb830cdb5e00add400bc583dac203</citedby><cites>FETCH-LOGICAL-c337t-b32d76e16f807b67a0ae0e055e251906065cbb830cdb5e00add400bc583dac203</cites><orcidid>0000-0003-0388-4633 ; 0000-0003-3161-7698 ; 0000-0002-5870-687X ; 0000-0001-6339-1190</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34076031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elbatrawy, Ahmed A</creatorcontrib><creatorcontrib>Lee, Da Sol</creatorcontrib><creatorcontrib>Lee, Sang Bong</creatorcontrib><creatorcontrib>Jeon, Hui-Jeon</creatorcontrib><creatorcontrib>Lee, Sijoon</creatorcontrib><creatorcontrib>Kang, Kyung-ku</creatorcontrib><creatorcontrib>Sung, Soo-Eun</creatorcontrib><creatorcontrib>Han, Ye Ri</creatorcontrib><creatorcontrib>Cho, Sung Jin</creatorcontrib><creatorcontrib>Kim, Dong-Su</creatorcontrib><creatorcontrib>Kim, Kil Soo</creatorcontrib><creatorcontrib>Nam, Ghilsoo</creatorcontrib><creatorcontrib>Jeon, Yong Hyun</creatorcontrib><title>Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.
In vivo
fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without
in vivo
toxicity, which was consistent with the findings of
ex vivo
imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.
A novel near-infrared fluorescent imaging probe, KSNP117, was developed. Its excellent stability and biocompatibility were confirmed
in vitro
and
in vivo
, and its biomedical application for sentinel lymph node mapping was successfully demonstrated.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Brightening</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Female</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent indicators</subject><subject>Fluoroscopic imaging</subject><subject>Humans</subject><subject>Immune system</subject><subject>Lymph nodes</subject><subject>Medical imaging</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Molecular Structure</subject><subject>Optical Imaging</subject><subject>Quinoline</subject><subject>Quinolines - chemistry</subject><subject>Sentinel Lymph Node - diagnostic imaging</subject><subject>Sentinel Lymph Node - pathology</subject><subject>Toxicity</subject><issn>2050-750X</issn><issn>2050-7518</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1LwzAYBvAgihPdxbsS8CKy6pumSbujH_MDRQUneBBK0rzVStvUZBX23xudTjCXBPLLy8MTQrYZHDLg4yPDZhpAyAxXyEYMAqJUsGx1eYanARl6_wZhZUxmPFknA55AKoGzDfJ8az-wpu991dq6ajHSyqOhZd1bh77AdkZ1ZatGvVTtC-2c1Tii1w-394ylI1paR30w4WFN63nTvdLWGqSN6rrgt8haqWqPw599kzyeT6anl9HN3cXV6fFNVHCeziLNY5NKZLLMINUyVaAQEITAWLAxSJCi0DrjUBgtEEAZkwDoQmTcqCIGvkn2F3NDvvce_SxvqpC9rlWLtvd5LLhM0nEcs0D3_tE327s2pAsqSVgmhIyDOliowlnvHZZ550IHbp4zyL9qz8_Y9OS79knAuz8je92gWdLfkgPYWQDni-Xt37_xTxobhXU</recordid><startdate>20210623</startdate><enddate>20210623</enddate><creator>Elbatrawy, Ahmed A</creator><creator>Lee, Da Sol</creator><creator>Lee, Sang Bong</creator><creator>Jeon, Hui-Jeon</creator><creator>Lee, Sijoon</creator><creator>Kang, Kyung-ku</creator><creator>Sung, Soo-Eun</creator><creator>Han, Ye Ri</creator><creator>Cho, Sung Jin</creator><creator>Kim, Dong-Su</creator><creator>Kim, Kil Soo</creator><creator>Nam, Ghilsoo</creator><creator>Jeon, Yong Hyun</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0388-4633</orcidid><orcidid>https://orcid.org/0000-0003-3161-7698</orcidid><orcidid>https://orcid.org/0000-0002-5870-687X</orcidid><orcidid>https://orcid.org/0000-0001-6339-1190</orcidid></search><sort><creationdate>20210623</creationdate><title>Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping</title><author>Elbatrawy, Ahmed A ; Lee, Da Sol ; Lee, Sang Bong ; Jeon, Hui-Jeon ; Lee, Sijoon ; Kang, Kyung-ku ; Sung, Soo-Eun ; Han, Ye Ri ; Cho, Sung Jin ; Kim, Dong-Su ; Kim, Kil Soo ; Nam, Ghilsoo ; Jeon, Yong Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-b32d76e16f807b67a0ae0e055e251906065cbb830cdb5e00add400bc583dac203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Brightening</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Female</topic><topic>Fluorescent Dyes - chemical synthesis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent indicators</topic><topic>Fluoroscopic imaging</topic><topic>Humans</topic><topic>Immune system</topic><topic>Lymph nodes</topic><topic>Medical imaging</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Molecular Structure</topic><topic>Optical Imaging</topic><topic>Quinoline</topic><topic>Quinolines - chemistry</topic><topic>Sentinel Lymph Node - diagnostic imaging</topic><topic>Sentinel Lymph Node - pathology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elbatrawy, Ahmed A</creatorcontrib><creatorcontrib>Lee, Da Sol</creatorcontrib><creatorcontrib>Lee, Sang Bong</creatorcontrib><creatorcontrib>Jeon, Hui-Jeon</creatorcontrib><creatorcontrib>Lee, Sijoon</creatorcontrib><creatorcontrib>Kang, Kyung-ku</creatorcontrib><creatorcontrib>Sung, Soo-Eun</creatorcontrib><creatorcontrib>Han, Ye Ri</creatorcontrib><creatorcontrib>Cho, Sung Jin</creatorcontrib><creatorcontrib>Kim, Dong-Su</creatorcontrib><creatorcontrib>Kim, Kil Soo</creatorcontrib><creatorcontrib>Nam, Ghilsoo</creatorcontrib><creatorcontrib>Jeon, Yong Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elbatrawy, Ahmed A</au><au>Lee, Da Sol</au><au>Lee, Sang Bong</au><au>Jeon, Hui-Jeon</au><au>Lee, Sijoon</au><au>Kang, Kyung-ku</au><au>Sung, Soo-Eun</au><au>Han, Ye Ri</au><au>Cho, Sung Jin</au><au>Kim, Dong-Su</au><au>Kim, Kil Soo</au><au>Nam, Ghilsoo</au><au>Jeon, Yong Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2021-06-23</date><risdate>2021</risdate><volume>9</volume><issue>24</issue><spage>4857</spage><epage>4862</epage><pages>4857-4862</pages><issn>2050-750X</issn><issn>2050-7518</issn><eissn>2050-7518</eissn><abstract>Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.
In vivo
fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without
in vivo
toxicity, which was consistent with the findings of
ex vivo
imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.
A novel near-infrared fluorescent imaging probe, KSNP117, was developed. Its excellent stability and biocompatibility were confirmed
in vitro
and
in vivo
, and its biomedical application for sentinel lymph node mapping was successfully demonstrated.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34076031</pmid><doi>10.1039/d1tb00568e</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0388-4633</orcidid><orcidid>https://orcid.org/0000-0003-3161-7698</orcidid><orcidid>https://orcid.org/0000-0002-5870-687X</orcidid><orcidid>https://orcid.org/0000-0001-6339-1190</orcidid></addata></record> |
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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2021-06, Vol.9 (24), p.4857-4862 |
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| language | eng |
| recordid | cdi_pubmed_primary_34076031 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Biocompatibility Biomedical materials Brightening Cell proliferation Cell Proliferation - drug effects Female Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent indicators Fluoroscopic imaging Humans Immune system Lymph nodes Medical imaging Mice Mice, Inbred BALB C Mice, Nude Molecular Structure Optical Imaging Quinoline Quinolines - chemistry Sentinel Lymph Node - diagnostic imaging Sentinel Lymph Node - pathology Toxicity |
| title | Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping |
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