Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy

Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in p...

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Veröffentlicht in:Digestive surgery 2021-09, Vol.38 (4), p.275-282
Hauptverfasser: Shinde, Rajesh, Bhandare, Manish Suresh, Chaudhari, Vikram, Sarodaya, Varun, Agarwal, Vandana, Shrikhande, Shailesh
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container_end_page 282
container_issue 4
container_start_page 275
container_title Digestive surgery
container_volume 38
creator Shinde, Rajesh
Bhandare, Manish Suresh
Chaudhari, Vikram
Sarodaya, Varun
Agarwal, Vandana
Shrikhande, Shailesh
description Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD.
doi_str_mv 10.1159/000516278
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Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR &lt;1). Two groups were compared for perioperative and long-term survival outcomes. Results: Two groups were comparable with respect to clinicodemographic variables. Groups I and II had similar perioperative outcomes (p &gt; 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD.</description><identifier>ISSN: 0253-4886</identifier><identifier>EISSN: 1421-9883</identifier><identifier>DOI: 10.1159/000516278</identifier><identifier>PMID: 34038911</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Humans ; Pancreaticoduodenectomy ; Perioperative Period ; Preoperative Period ; Research Article ; Serum Albumin - analysis ; Serum Globulins - analysis ; Treatment Outcome</subject><ispartof>Digestive surgery, 2021-09, Vol.38 (4), p.275-282</ispartof><rights>2021 S. Karger AG, Basel</rights><rights>2021 S. 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Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR &lt;1). Two groups were compared for perioperative and long-term survival outcomes. Results: Two groups were comparable with respect to clinicodemographic variables. Groups I and II had similar perioperative outcomes (p &gt; 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). 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source MEDLINE; Karger Journals
subjects Humans
Pancreaticoduodenectomy
Perioperative Period
Preoperative Period
Research Article
Serum Albumin - analysis
Serum Globulins - analysis
Treatment Outcome
title Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy
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