Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy
Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in p...
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Veröffentlicht in: | Digestive surgery 2021-09, Vol.38 (4), p.275-282 |
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creator | Shinde, Rajesh Bhandare, Manish Suresh Chaudhari, Vikram Sarodaya, Varun Agarwal, Vandana Shrikhande, Shailesh |
description | Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD. |
doi_str_mv | 10.1159/000516278 |
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Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR <1). Two groups were compared for perioperative and long-term survival outcomes. Results: Two groups were comparable with respect to clinicodemographic variables. Groups I and II had similar perioperative outcomes (p > 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD.</description><identifier>ISSN: 0253-4886</identifier><identifier>EISSN: 1421-9883</identifier><identifier>DOI: 10.1159/000516278</identifier><identifier>PMID: 34038911</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Humans ; Pancreaticoduodenectomy ; Perioperative Period ; Preoperative Period ; Research Article ; Serum Albumin - analysis ; Serum Globulins - analysis ; Treatment Outcome</subject><ispartof>Digestive surgery, 2021-09, Vol.38 (4), p.275-282</ispartof><rights>2021 S. Karger AG, Basel</rights><rights>2021 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-d015dce657fe86dce0b71246ee10b8fb5fc63adc2d3becfe14832b688ce05bdb3</citedby><cites>FETCH-LOGICAL-c334t-d015dce657fe86dce0b71246ee10b8fb5fc63adc2d3becfe14832b688ce05bdb3</cites><orcidid>0000-0003-4999-5144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,2425,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34038911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinde, Rajesh</creatorcontrib><creatorcontrib>Bhandare, Manish Suresh</creatorcontrib><creatorcontrib>Chaudhari, Vikram</creatorcontrib><creatorcontrib>Sarodaya, Varun</creatorcontrib><creatorcontrib>Agarwal, Vandana</creatorcontrib><creatorcontrib>Shrikhande, Shailesh</creatorcontrib><title>Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy</title><title>Digestive surgery</title><addtitle>Dig Surg</addtitle><description>Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR <1). Two groups were compared for perioperative and long-term survival outcomes. Results: Two groups were comparable with respect to clinicodemographic variables. Groups I and II had similar perioperative outcomes (p > 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD.</description><subject>Humans</subject><subject>Pancreaticoduodenectomy</subject><subject>Perioperative Period</subject><subject>Preoperative Period</subject><subject>Research Article</subject><subject>Serum Albumin - analysis</subject><subject>Serum Globulins - analysis</subject><subject>Treatment Outcome</subject><issn>0253-4886</issn><issn>1421-9883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1LwzAcBvAgis7pwbtIwIseqknTl-w4ps7BwKHuXJrk3xltk5m0il_Cz2zG5rx4Snj45Qk8CJ1QckVpOrgmhKQ0i3O-g3o0iWk04Jztoh6JUxYlnGcH6ND718BYNqD76IAlhPEBpT30PXNgl-DKVn8AHtaia7SJxrUVXa0Nfgy5xaVReNJ6PPTeSr2KDP7U7QuegdN_r1dsas0iegbX4IeulbYBj0PNLAAwoWFuFLiF1WYRMiMdlK1VnVVgQLa2-TpCe1VZezjenH00v7t9Ht1H04fxZDScRpKxpI0UoamSkKV5BTwLNyJyGicZACWCVyKtZMZKJWPFBMgKaMJZLDLOg0yFEqyPLta9S2ffO_Bt0Wgvoa5LA7bzRRiOMZrnlAV6uabSWe8dVMXS6aZ0XwUlxWr-Yjt_sGeb2k40oLbyd-8AztfgrXQLcFtw8zRfVxRLVQV1-q_a_PIDRS2YtQ</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Shinde, Rajesh</creator><creator>Bhandare, Manish Suresh</creator><creator>Chaudhari, Vikram</creator><creator>Sarodaya, Varun</creator><creator>Agarwal, Vandana</creator><creator>Shrikhande, Shailesh</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4999-5144</orcidid></search><sort><creationdate>20210901</creationdate><title>Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy</title><author>Shinde, Rajesh ; Bhandare, Manish Suresh ; Chaudhari, Vikram ; Sarodaya, Varun ; Agarwal, Vandana ; Shrikhande, Shailesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-d015dce657fe86dce0b71246ee10b8fb5fc63adc2d3becfe14832b688ce05bdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Humans</topic><topic>Pancreaticoduodenectomy</topic><topic>Perioperative Period</topic><topic>Preoperative Period</topic><topic>Research Article</topic><topic>Serum Albumin - analysis</topic><topic>Serum Globulins - analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinde, Rajesh</creatorcontrib><creatorcontrib>Bhandare, Manish Suresh</creatorcontrib><creatorcontrib>Chaudhari, Vikram</creatorcontrib><creatorcontrib>Sarodaya, Varun</creatorcontrib><creatorcontrib>Agarwal, Vandana</creatorcontrib><creatorcontrib>Shrikhande, Shailesh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinde, Rajesh</au><au>Bhandare, Manish Suresh</au><au>Chaudhari, Vikram</au><au>Sarodaya, Varun</au><au>Agarwal, Vandana</au><au>Shrikhande, Shailesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy</atitle><jtitle>Digestive surgery</jtitle><addtitle>Dig Surg</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>38</volume><issue>4</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>0253-4886</issn><eissn>1421-9883</eissn><abstract>Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR <1). Two groups were compared for perioperative and long-term survival outcomes. Results: Two groups were comparable with respect to clinicodemographic variables. Groups I and II had similar perioperative outcomes (p > 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD.</abstract><cop>Basel, Switzerland</cop><pmid>34038911</pmid><doi>10.1159/000516278</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4999-5144</orcidid></addata></record> |
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subjects | Humans Pancreaticoduodenectomy Perioperative Period Preoperative Period Research Article Serum Albumin - analysis Serum Globulins - analysis Treatment Outcome |
title | Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy |
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