Clinical outcomes and quality of life of COVID-19 survivors: A follow-up of 3 months post hospital discharge
Over 66 million people worldwide have been diagnosed with COVID-19. Therefore, understanding their clinical evolution beyond hospital discharge is essential not only from an individual standpoint, but from a populational level. Our primary aim was to assess the impact of COVID-19 on health-related q...
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| Veröffentlicht in: | Respiratory medicine 2021-08, Vol.184, p.106453-106453, Article 106453 |
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| creator | Todt, Beatriz Costa Szlejf, Claudia Duim, Etienne Linhares, Alana O.M. Kogiso, Diogo Varela, Gabriela Campos, Bruna A. Baghelli Fonseca, Cristina Mara Polesso, Leonardo E. Bordon, Ingra N.S. Cabral, Bruno T. Amorim, Victor L.P. Piza, Felipe M.T. Degani-Costa, Luiza Helena |
| description | Over 66 million people worldwide have been diagnosed with COVID-19. Therefore, understanding their clinical evolution beyond hospital discharge is essential not only from an individual standpoint, but from a populational level.
Our primary aim was to assess the impact of COVID-19 on health-related quality of life (HRQoL) 3 months after hospital discharge. Additionally, we screened for anxiety and depression and assessed important clinical outcomes.
This was a single-center cohort study performed in Sao Paulo (Brazil), in which participants were contacted by telephone to answer a short survey. EQ-5D-3L was used to assess HRQoL and clinical data from patients’ index admission were retrieved from medical records.
We contacted 251 participants (59.8% males, mean age 53 years old), 69.7% of which had presented with severe COVID-19. At 3 months of follow-up, 6 patients had died, 51 (20.3%) had visited the emergency department again and 17 (6.8%) had been readmitted to hospital. Seventy patients (27.9%) persisted with increased dyspnoea and 81 had a positive screening for anxiety/depression. Similarly, patients reported an overall worsening of EQ-5D-3L single summary index at 3 months compared to before the onset of COVID-19 symptoms (0.8012 (0.7368 – 1.0) vs. 1.0(0.7368 – 1.0), p |
| doi_str_mv | 10.1016/j.rmed.2021.106453 |
| format | Article |
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Our primary aim was to assess the impact of COVID-19 on health-related quality of life (HRQoL) 3 months after hospital discharge. Additionally, we screened for anxiety and depression and assessed important clinical outcomes.
This was a single-center cohort study performed in Sao Paulo (Brazil), in which participants were contacted by telephone to answer a short survey. EQ-5D-3L was used to assess HRQoL and clinical data from patients’ index admission were retrieved from medical records.
We contacted 251 participants (59.8% males, mean age 53 years old), 69.7% of which had presented with severe COVID-19. At 3 months of follow-up, 6 patients had died, 51 (20.3%) had visited the emergency department again and 17 (6.8%) had been readmitted to hospital. Seventy patients (27.9%) persisted with increased dyspnoea and 81 had a positive screening for anxiety/depression. Similarly, patients reported an overall worsening of EQ-5D-3L single summary index at 3 months compared to before the onset of COVID-19 symptoms (0.8012 (0.7368 – 1.0) vs. 1.0(0.7368 – 1.0), p < 0.001). This affected all 5 domains, but especially pain/discomfort and anxiety/depression. Only female sex and intensive care requirement were independently associated with worsening of HRQoL.
Patients hospitalized for COVID-19 frequently face persistent clinical and mental health problems up to 3 months following hospital discharge, with significant impact on patients’ HRQoL.
•COVID-19 admission is associated with persistent clinical and mental health problems.•Dyspnoea persists up to 3 months following hospital discharge in many patients.•HRQoL is significantly worsened up to 3 months following hospital discharge.•Pain/discomfort and anxiety/depression were the most impacted domains of HRQoL.•Female sex and intensive care requirement were associated with worsening of HRQoL.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2021.106453</identifier><identifier>PMID: 34010740</identifier><language>eng</language><publisher>LONDON: Elsevier Ltd</publisher><subject>Anxiety ; Brazil ; Cardiac & Cardiovascular Systems ; Cardiovascular System & Cardiology ; Clinical outcomes ; Cohort Studies ; Consent ; Coronaviruses ; COVID-19 ; COVID-19 - psychology ; Critical care ; Critical Care Outcomes ; Data collection ; Depression ; Dyspnea ; Emergency medical care ; Emergency medical services ; Female ; Follow-Up Studies ; Health care ; Health problems ; Hospitals ; Humans ; Interviews ; Life Sciences & Biomedicine ; Male ; Medical records ; Medical research ; Mental depression ; Mental disorders ; Mental Health ; Middle Aged ; Mortality ; Original Research ; Pain ; Pandemics ; Patient Discharge ; Patients ; Population ; Quality of Life ; Questionnaires ; Respiration ; Respiratory System ; Science & Technology ; Severe acute respiratory syndrome coronavirus 2 ; Sex Factors ; Surveys and Questionnaires ; Survivors ; Time Factors</subject><ispartof>Respiratory medicine, 2021-08, Vol.184, p.106453-106453, Article 106453</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>2021. Elsevier Ltd</rights><rights>2021 Elsevier Ltd. All rights reserved. 2021 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>55</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000660971700003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c483t-e9d3372ec7a2a23bae53ac2c12ab65c20e878d198b2abe74b730be7db85f49513</citedby><cites>FETCH-LOGICAL-c483t-e9d3372ec7a2a23bae53ac2c12ab65c20e878d198b2abe74b730be7db85f49513</cites><orcidid>0000-0002-0569-1184 ; 0000-0001-5968-7853 ; 0000-0001-7008-886X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2021.106453$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,39262,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34010740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todt, Beatriz Costa</creatorcontrib><creatorcontrib>Szlejf, Claudia</creatorcontrib><creatorcontrib>Duim, Etienne</creatorcontrib><creatorcontrib>Linhares, Alana O.M.</creatorcontrib><creatorcontrib>Kogiso, Diogo</creatorcontrib><creatorcontrib>Varela, Gabriela</creatorcontrib><creatorcontrib>Campos, Bruna A.</creatorcontrib><creatorcontrib>Baghelli Fonseca, Cristina Mara</creatorcontrib><creatorcontrib>Polesso, Leonardo E.</creatorcontrib><creatorcontrib>Bordon, Ingra N.S.</creatorcontrib><creatorcontrib>Cabral, Bruno T.</creatorcontrib><creatorcontrib>Amorim, Victor L.P.</creatorcontrib><creatorcontrib>Piza, Felipe M.T.</creatorcontrib><creatorcontrib>Degani-Costa, Luiza Helena</creatorcontrib><title>Clinical outcomes and quality of life of COVID-19 survivors: A follow-up of 3 months post hospital discharge</title><title>Respiratory medicine</title><addtitle>RESP MED</addtitle><addtitle>Respir Med</addtitle><description>Over 66 million people worldwide have been diagnosed with COVID-19. Therefore, understanding their clinical evolution beyond hospital discharge is essential not only from an individual standpoint, but from a populational level.
Our primary aim was to assess the impact of COVID-19 on health-related quality of life (HRQoL) 3 months after hospital discharge. Additionally, we screened for anxiety and depression and assessed important clinical outcomes.
This was a single-center cohort study performed in Sao Paulo (Brazil), in which participants were contacted by telephone to answer a short survey. EQ-5D-3L was used to assess HRQoL and clinical data from patients’ index admission were retrieved from medical records.
We contacted 251 participants (59.8% males, mean age 53 years old), 69.7% of which had presented with severe COVID-19. At 3 months of follow-up, 6 patients had died, 51 (20.3%) had visited the emergency department again and 17 (6.8%) had been readmitted to hospital. Seventy patients (27.9%) persisted with increased dyspnoea and 81 had a positive screening for anxiety/depression. Similarly, patients reported an overall worsening of EQ-5D-3L single summary index at 3 months compared to before the onset of COVID-19 symptoms (0.8012 (0.7368 – 1.0) vs. 1.0(0.7368 – 1.0), p < 0.001). This affected all 5 domains, but especially pain/discomfort and anxiety/depression. Only female sex and intensive care requirement were independently associated with worsening of HRQoL.
Patients hospitalized for COVID-19 frequently face persistent clinical and mental health problems up to 3 months following hospital discharge, with significant impact on patients’ HRQoL.
•COVID-19 admission is associated with persistent clinical and mental health problems.•Dyspnoea persists up to 3 months following hospital discharge in many patients.•HRQoL is significantly worsened up to 3 months following hospital discharge.•Pain/discomfort and anxiety/depression were the most impacted domains of HRQoL.•Female sex and intensive care requirement were associated with worsening of HRQoL.</description><subject>Anxiety</subject><subject>Brazil</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiovascular System & Cardiology</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Consent</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - psychology</subject><subject>Critical care</subject><subject>Critical Care Outcomes</subject><subject>Data collection</subject><subject>Depression</subject><subject>Dyspnea</subject><subject>Emergency medical care</subject><subject>Emergency medical services</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health care</subject><subject>Health problems</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Interviews</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Pain</subject><subject>Pandemics</subject><subject>Patient Discharge</subject><subject>Patients</subject><subject>Population</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Respiration</subject><subject>Respiratory System</subject><subject>Science & Technology</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sex Factors</subject><subject>Surveys and 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Beatriz Costa</creator><creator>Szlejf, Claudia</creator><creator>Duim, Etienne</creator><creator>Linhares, Alana O.M.</creator><creator>Kogiso, Diogo</creator><creator>Varela, Gabriela</creator><creator>Campos, Bruna A.</creator><creator>Baghelli Fonseca, Cristina Mara</creator><creator>Polesso, Leonardo E.</creator><creator>Bordon, Ingra N.S.</creator><creator>Cabral, Bruno T.</creator><creator>Amorim, Victor L.P.</creator><creator>Piza, Felipe M.T.</creator><creator>Degani-Costa, Luiza Helena</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier 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medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todt, Beatriz Costa</au><au>Szlejf, Claudia</au><au>Duim, Etienne</au><au>Linhares, Alana O.M.</au><au>Kogiso, Diogo</au><au>Varela, Gabriela</au><au>Campos, Bruna A.</au><au>Baghelli Fonseca, Cristina Mara</au><au>Polesso, Leonardo E.</au><au>Bordon, Ingra N.S.</au><au>Cabral, Bruno T.</au><au>Amorim, Victor L.P.</au><au>Piza, Felipe M.T.</au><au>Degani-Costa, Luiza Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcomes and quality of life of COVID-19 survivors: A follow-up of 3 months post hospital discharge</atitle><jtitle>Respiratory medicine</jtitle><stitle>RESP MED</stitle><addtitle>Respir Med</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>184</volume><spage>106453</spage><epage>106453</epage><pages>106453-106453</pages><artnum>106453</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Over 66 million people worldwide have been diagnosed with COVID-19. Therefore, understanding their clinical evolution beyond hospital discharge is essential not only from an individual standpoint, but from a populational level.
Our primary aim was to assess the impact of COVID-19 on health-related quality of life (HRQoL) 3 months after hospital discharge. Additionally, we screened for anxiety and depression and assessed important clinical outcomes.
This was a single-center cohort study performed in Sao Paulo (Brazil), in which participants were contacted by telephone to answer a short survey. EQ-5D-3L was used to assess HRQoL and clinical data from patients’ index admission were retrieved from medical records.
We contacted 251 participants (59.8% males, mean age 53 years old), 69.7% of which had presented with severe COVID-19. At 3 months of follow-up, 6 patients had died, 51 (20.3%) had visited the emergency department again and 17 (6.8%) had been readmitted to hospital. Seventy patients (27.9%) persisted with increased dyspnoea and 81 had a positive screening for anxiety/depression. Similarly, patients reported an overall worsening of EQ-5D-3L single summary index at 3 months compared to before the onset of COVID-19 symptoms (0.8012 (0.7368 – 1.0) vs. 1.0(0.7368 – 1.0), p < 0.001). This affected all 5 domains, but especially pain/discomfort and anxiety/depression. Only female sex and intensive care requirement were independently associated with worsening of HRQoL.
Patients hospitalized for COVID-19 frequently face persistent clinical and mental health problems up to 3 months following hospital discharge, with significant impact on patients’ HRQoL.
•COVID-19 admission is associated with persistent clinical and mental health problems.•Dyspnoea persists up to 3 months following hospital discharge in many patients.•HRQoL is significantly worsened up to 3 months following hospital discharge.•Pain/discomfort and anxiety/depression were the most impacted domains of HRQoL.•Female sex and intensive care requirement were associated with worsening of HRQoL.</abstract><cop>LONDON</cop><pub>Elsevier Ltd</pub><pmid>34010740</pmid><doi>10.1016/j.rmed.2021.106453</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0569-1184</orcidid><orcidid>https://orcid.org/0000-0001-5968-7853</orcidid><orcidid>https://orcid.org/0000-0001-7008-886X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0954-6111 |
| ispartof | Respiratory medicine, 2021-08, Vol.184, p.106453-106453, Article 106453 |
| issn | 0954-6111 1532-3064 |
| language | eng |
| recordid | cdi_pubmed_primary_34010740 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via ScienceDirect (Elsevier); Web of Science - Social Sciences Citation Index – 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Anxiety Brazil Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Clinical outcomes Cohort Studies Consent Coronaviruses COVID-19 COVID-19 - psychology Critical care Critical Care Outcomes Data collection Depression Dyspnea Emergency medical care Emergency medical services Female Follow-Up Studies Health care Health problems Hospitals Humans Interviews Life Sciences & Biomedicine Male Medical records Medical research Mental depression Mental disorders Mental Health Middle Aged Mortality Original Research Pain Pandemics Patient Discharge Patients Population Quality of Life Questionnaires Respiration Respiratory System Science & Technology Severe acute respiratory syndrome coronavirus 2 Sex Factors Surveys and Questionnaires Survivors Time Factors |
| title | Clinical outcomes and quality of life of COVID-19 survivors: A follow-up of 3 months post hospital discharge |
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