Sex hormones and immune system: A possible interplay in affective disorders? A systematic review
•The gonadal-immune interplay in depression is unclear.•Testosterone may be protective in bipolar depression in men through anti-inflammatory effects.•Hormonal therapy may be protective in peri/post menopausal women through anti-inflammatory effects.•Conclusions limited by study number and study het...
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| Veröffentlicht in: | Journal of affective disorders 2021-07, Vol.290, p.1-14 |
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| container_title | Journal of affective disorders |
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| creator | Lombardo, Giulia Mondelli, Valeria Dazzan, Paola Pariante, Carmine Maria |
| description | •The gonadal-immune interplay in depression is unclear.•Testosterone may be protective in bipolar depression in men through anti-inflammatory effects.•Hormonal therapy may be protective in peri/post menopausal women through anti-inflammatory effects.•Conclusions limited by study number and study heterogeneity
Sex hormones and the immune system may play a key role in sex differences in affective disorders. The understanding of their interplay may lead to the detection of new sex-specific tailored therapeutic approaches. The aim of this systematic review is to summarise the evidence supporting a possible association between sex hormones and inflammatory biomarkers in people with affective disorders.
A systematic search of the literature published until January 2021 was conducted on PubMed database. The initial search identified a total of 1259 studies; 20 studies investigating inflammatory biomarkers and sex hormones in patients exhibiting depressive symptoms were included: 10 studies focused on patients with affective disorders, and 10 studies focused on women in menopause or in the post-partum period exhibiting depressive symptoms.
Testosterone and exogenous female sex hormones may play protective roles through their modulation of the immune system, respectively, in male patients with bipolar disorder and in peri-/post-menopausal women with depression.
The main limitations are the paucity of studies investigating both sex hormones and immune biomarkers, the lack of statistical analyses exploring specifically the association between these two classes of biomarkers, and the great heterogeneity between the participants’ samples in the studies.
This review highlights the need to investigate the interplay between sex hormones and immune system in affective disorders. The inconsistent or incomplete evidence may be improved by studies in patients with moderate-high inflammatory levels that specifically evaluate the relationship between sex hormones and the immune system. |
| doi_str_mv | 10.1016/j.jad.2021.04.035 |
| format | Article |
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Sex hormones and the immune system may play a key role in sex differences in affective disorders. The understanding of their interplay may lead to the detection of new sex-specific tailored therapeutic approaches. The aim of this systematic review is to summarise the evidence supporting a possible association between sex hormones and inflammatory biomarkers in people with affective disorders.
A systematic search of the literature published until January 2021 was conducted on PubMed database. The initial search identified a total of 1259 studies; 20 studies investigating inflammatory biomarkers and sex hormones in patients exhibiting depressive symptoms were included: 10 studies focused on patients with affective disorders, and 10 studies focused on women in menopause or in the post-partum period exhibiting depressive symptoms.
Testosterone and exogenous female sex hormones may play protective roles through their modulation of the immune system, respectively, in male patients with bipolar disorder and in peri-/post-menopausal women with depression.
The main limitations are the paucity of studies investigating both sex hormones and immune biomarkers, the lack of statistical analyses exploring specifically the association between these two classes of biomarkers, and the great heterogeneity between the participants’ samples in the studies.
This review highlights the need to investigate the interplay between sex hormones and immune system in affective disorders. The inconsistent or incomplete evidence may be improved by studies in patients with moderate-high inflammatory levels that specifically evaluate the relationship between sex hormones and the immune system.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2021.04.035</identifier><identifier>PMID: 33989924</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Affective disorders ; Bipolar disorder ; Clinical Neurology ; Inflammatory biomarkers ; Life Sciences & Biomedicine ; Major depressive disorder ; Neurosciences & Neurology ; Post-partum depression ; Psychiatry ; Science & Technology ; Sex hormones</subject><ispartof>Journal of affective disorders, 2021-07, Vol.290, p.1-14</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>17</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000663776700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c353t-24488d1f93d57943fb29a6bced6ba3b76dc5937ff2fb41757e3eae38cbe0148e3</citedby><cites>FETCH-LOGICAL-c353t-24488d1f93d57943fb29a6bced6ba3b76dc5937ff2fb41757e3eae38cbe0148e3</cites><orcidid>0000-0003-2794-3917 ; 0000-0002-8427-3617 ; 0000-0001-8690-6839</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2021.04.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,39266,39267,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33989924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lombardo, Giulia</creatorcontrib><creatorcontrib>Mondelli, Valeria</creatorcontrib><creatorcontrib>Dazzan, Paola</creatorcontrib><creatorcontrib>Pariante, Carmine Maria</creatorcontrib><title>Sex hormones and immune system: A possible interplay in affective disorders? A systematic review</title><title>Journal of affective disorders</title><addtitle>J AFFECT DISORDERS</addtitle><addtitle>J Affect Disord</addtitle><description>•The gonadal-immune interplay in depression is unclear.•Testosterone may be protective in bipolar depression in men through anti-inflammatory effects.•Hormonal therapy may be protective in peri/post menopausal women through anti-inflammatory effects.•Conclusions limited by study number and study heterogeneity
Sex hormones and the immune system may play a key role in sex differences in affective disorders. The understanding of their interplay may lead to the detection of new sex-specific tailored therapeutic approaches. The aim of this systematic review is to summarise the evidence supporting a possible association between sex hormones and inflammatory biomarkers in people with affective disorders.
A systematic search of the literature published until January 2021 was conducted on PubMed database. The initial search identified a total of 1259 studies; 20 studies investigating inflammatory biomarkers and sex hormones in patients exhibiting depressive symptoms were included: 10 studies focused on patients with affective disorders, and 10 studies focused on women in menopause or in the post-partum period exhibiting depressive symptoms.
Testosterone and exogenous female sex hormones may play protective roles through their modulation of the immune system, respectively, in male patients with bipolar disorder and in peri-/post-menopausal women with depression.
The main limitations are the paucity of studies investigating both sex hormones and immune biomarkers, the lack of statistical analyses exploring specifically the association between these two classes of biomarkers, and the great heterogeneity between the participants’ samples in the studies.
This review highlights the need to investigate the interplay between sex hormones and immune system in affective disorders. The inconsistent or incomplete evidence may be improved by studies in patients with moderate-high inflammatory levels that specifically evaluate the relationship between sex hormones and the immune system.</description><subject>Affective disorders</subject><subject>Bipolar disorder</subject><subject>Clinical Neurology</subject><subject>Inflammatory biomarkers</subject><subject>Life Sciences & Biomedicine</subject><subject>Major depressive disorder</subject><subject>Neurosciences & Neurology</subject><subject>Post-partum depression</subject><subject>Psychiatry</subject><subject>Science & Technology</subject><subject>Sex hormones</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><recordid>eNqNkctu1DAUQC0EotPCB7BBXiKhBD_iOIEFqkblIVXqorA2flwLj5J4sJO28_f1KEOXiJXv4pwr-xihN5TUlND2w67eaVczwmhNmppw8QxtqJC8YoLK52hTGFERzuQZOs95Rwhpe0leojPO-67vWbNBv27hAf-OaYwTZKwnh8M4LhPgfMgzjB_xJd7HnIMZAIdphrQf9KFMWHsPdg53gF3IMTlI-XOBV03PweIEdwHuX6EXXg8ZXp_OC_Tzy9WP7bfq-ubr9-3ldWW54HPFmqbrHPU9d0L2DfeG9bo1FlxrNDeydVb0XHrPvGmoFBI4aOCdNUBo0wG_QO_WvfsU_yyQZzWGbGEY9ARxyYoJ1tGO8ZYWlK6oTeVpCbzapzDqdFCUqGNYtVMlrDqGVaRRJWxx3p7WL2YE92T8LVmA9ytwDyb6bANMFp6wY_qWS9nKMpHjFbr_p7dhLkHjtI3LNBf106pCqVkKJ3XSXUjlR5SL4R_veAQFFqqg</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Lombardo, Giulia</creator><creator>Mondelli, Valeria</creator><creator>Dazzan, Paola</creator><creator>Pariante, Carmine Maria</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2794-3917</orcidid><orcidid>https://orcid.org/0000-0002-8427-3617</orcidid><orcidid>https://orcid.org/0000-0001-8690-6839</orcidid></search><sort><creationdate>20210701</creationdate><title>Sex hormones and immune system: A possible interplay in affective disorders? A systematic review</title><author>Lombardo, Giulia ; Mondelli, Valeria ; Dazzan, Paola ; Pariante, Carmine Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-24488d1f93d57943fb29a6bced6ba3b76dc5937ff2fb41757e3eae38cbe0148e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Affective disorders</topic><topic>Bipolar disorder</topic><topic>Clinical Neurology</topic><topic>Inflammatory biomarkers</topic><topic>Life Sciences & Biomedicine</topic><topic>Major depressive disorder</topic><topic>Neurosciences & Neurology</topic><topic>Post-partum depression</topic><topic>Psychiatry</topic><topic>Science & Technology</topic><topic>Sex hormones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lombardo, Giulia</creatorcontrib><creatorcontrib>Mondelli, Valeria</creatorcontrib><creatorcontrib>Dazzan, Paola</creatorcontrib><creatorcontrib>Pariante, Carmine Maria</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lombardo, Giulia</au><au>Mondelli, Valeria</au><au>Dazzan, Paola</au><au>Pariante, Carmine Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex hormones and immune system: A possible interplay in affective disorders? A systematic review</atitle><jtitle>Journal of affective disorders</jtitle><stitle>J AFFECT DISORDERS</stitle><addtitle>J Affect Disord</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>290</volume><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•The gonadal-immune interplay in depression is unclear.•Testosterone may be protective in bipolar depression in men through anti-inflammatory effects.•Hormonal therapy may be protective in peri/post menopausal women through anti-inflammatory effects.•Conclusions limited by study number and study heterogeneity
Sex hormones and the immune system may play a key role in sex differences in affective disorders. The understanding of their interplay may lead to the detection of new sex-specific tailored therapeutic approaches. The aim of this systematic review is to summarise the evidence supporting a possible association between sex hormones and inflammatory biomarkers in people with affective disorders.
A systematic search of the literature published until January 2021 was conducted on PubMed database. The initial search identified a total of 1259 studies; 20 studies investigating inflammatory biomarkers and sex hormones in patients exhibiting depressive symptoms were included: 10 studies focused on patients with affective disorders, and 10 studies focused on women in menopause or in the post-partum period exhibiting depressive symptoms.
Testosterone and exogenous female sex hormones may play protective roles through their modulation of the immune system, respectively, in male patients with bipolar disorder and in peri-/post-menopausal women with depression.
The main limitations are the paucity of studies investigating both sex hormones and immune biomarkers, the lack of statistical analyses exploring specifically the association between these two classes of biomarkers, and the great heterogeneity between the participants’ samples in the studies.
This review highlights the need to investigate the interplay between sex hormones and immune system in affective disorders. The inconsistent or incomplete evidence may be improved by studies in patients with moderate-high inflammatory levels that specifically evaluate the relationship between sex hormones and the immune system.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>33989924</pmid><doi>10.1016/j.jad.2021.04.035</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2794-3917</orcidid><orcidid>https://orcid.org/0000-0002-8427-3617</orcidid><orcidid>https://orcid.org/0000-0001-8690-6839</orcidid></addata></record> |
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| subjects | Affective disorders Bipolar disorder Clinical Neurology Inflammatory biomarkers Life Sciences & Biomedicine Major depressive disorder Neurosciences & Neurology Post-partum depression Psychiatry Science & Technology Sex hormones |
| title | Sex hormones and immune system: A possible interplay in affective disorders? A systematic review |
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