Wikstroemia ganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice
Plants of the genus are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether (Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopi...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2021-04, Vol.26 (7) |
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| container_title | Molecules (Basel, Switzerland) |
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| creator | Jegal, Jonghwan Park, No-June Jo, Beom-Geun Kim, Tae-Young Bong, Sim-Kyu Choi, Sangho Paik, Jin-Hyub Kim, Jung-Won Kim, Su-Nam Yang, Min Hye |
| description | Plants of the genus
are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether
(Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of
for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a
ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that
is a potential therapeutic agent for AD. |
| doi_str_mv | 10.3390/molecules26072016 |
| format | Article |
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are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether
(Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of
for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a
ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that
is a potential therapeutic agent for AD.</description><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules26072016</identifier><identifier>PMID: 33916154</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; Biopsy ; Chromatography, High Pressure Liquid ; Cytokines - genetics ; Cytokines - metabolism ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - etiology ; Dermatitis, Atopic - metabolism ; Dermatitis, Atopic - pathology ; Dinitrochlorobenzene - adverse effects ; Disease Models, Animal ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; Female ; Gene Expression ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Interleukin-4 - metabolism ; Mice ; Mice, Hairless ; Molecular Structure ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Treatment Outcome</subject><ispartof>Molecules (Basel, Switzerland), 2021-04, Vol.26 (7)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33916154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jegal, Jonghwan</creatorcontrib><creatorcontrib>Park, No-June</creatorcontrib><creatorcontrib>Jo, Beom-Geun</creatorcontrib><creatorcontrib>Kim, Tae-Young</creatorcontrib><creatorcontrib>Bong, Sim-Kyu</creatorcontrib><creatorcontrib>Choi, Sangho</creatorcontrib><creatorcontrib>Paik, Jin-Hyub</creatorcontrib><creatorcontrib>Kim, Jung-Won</creatorcontrib><creatorcontrib>Kim, Su-Nam</creatorcontrib><creatorcontrib>Yang, Min Hye</creatorcontrib><title>Wikstroemia ganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Plants of the genus
are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether
(Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of
for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a
ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that
is a potential therapeutic agent for AD.</description><subject>Animals</subject><subject>Biopsy</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - etiology</subject><subject>Dermatitis, Atopic - metabolism</subject><subject>Dermatitis, Atopic - pathology</subject><subject>Dinitrochlorobenzene - adverse effects</subject><subject>Disease Models, Animal</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Interleukin-4 - metabolism</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>Molecular Structure</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Treatment Outcome</subject><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kNFKwzAYhYMgbk4fwBvJAxhNmqRrL8emrljxYgMvR5r-1bg2LUk61JfxVY2oVwcO5zsHDkIXjF5zntObrm9Bjy34JKXzhLL0CE2ZSCjhVOQTdOr9G6UJE0yeoEkkWMqkmKKvZ7P3wfXQGYVflB0Mvn0PTumAi25w_QFqvAj9YDRegetUMMF4Upo94M3eWFyCN731-BDxzTgMDvyPgfsGFzaAa2GMMSJwzCZXgqyMNXFOv7a96yuwn2CBFLYedRzaPKwJw2tlIuY9fjQaztBxo1oP5386Q9u72-1yTcqn-2K5KMmQ80CU1o1Ma6GaRsg8q2QqqIa5pELxVM4VaJ5BAozLKmsymXGW5VUa71B5XQlo-Axd_tYOY9VBvRuc6ZT72P0fxb8B4IBtUA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Jegal, Jonghwan</creator><creator>Park, No-June</creator><creator>Jo, Beom-Geun</creator><creator>Kim, Tae-Young</creator><creator>Bong, Sim-Kyu</creator><creator>Choi, Sangho</creator><creator>Paik, Jin-Hyub</creator><creator>Kim, Jung-Won</creator><creator>Kim, Su-Nam</creator><creator>Yang, Min Hye</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20210401</creationdate><title>Wikstroemia ganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice</title><author>Jegal, Jonghwan ; Park, No-June ; Jo, Beom-Geun ; Kim, Tae-Young ; Bong, Sim-Kyu ; Choi, Sangho ; Paik, Jin-Hyub ; Kim, Jung-Won ; Kim, Su-Nam ; Yang, Min Hye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-accf56d4aff4598b5640ce7504a3657aec38e2e135b8f8583189b6021a9db4ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biopsy</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - etiology</topic><topic>Dermatitis, Atopic - metabolism</topic><topic>Dermatitis, Atopic - pathology</topic><topic>Dinitrochlorobenzene - adverse effects</topic><topic>Disease Models, Animal</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Interleukin-4 - metabolism</topic><topic>Mice</topic><topic>Mice, Hairless</topic><topic>Molecular Structure</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jegal, Jonghwan</creatorcontrib><creatorcontrib>Park, No-June</creatorcontrib><creatorcontrib>Jo, Beom-Geun</creatorcontrib><creatorcontrib>Kim, Tae-Young</creatorcontrib><creatorcontrib>Bong, Sim-Kyu</creatorcontrib><creatorcontrib>Choi, Sangho</creatorcontrib><creatorcontrib>Paik, Jin-Hyub</creatorcontrib><creatorcontrib>Kim, Jung-Won</creatorcontrib><creatorcontrib>Kim, Su-Nam</creatorcontrib><creatorcontrib>Yang, Min Hye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jegal, Jonghwan</au><au>Park, No-June</au><au>Jo, Beom-Geun</au><au>Kim, Tae-Young</au><au>Bong, Sim-Kyu</au><au>Choi, Sangho</au><au>Paik, Jin-Hyub</au><au>Kim, Jung-Won</au><au>Kim, Su-Nam</au><au>Yang, Min Hye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wikstroemia ganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>26</volume><issue>7</issue><eissn>1420-3049</eissn><abstract>Plants of the genus
are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether
(Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of
for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a
ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that
is a potential therapeutic agent for AD.</abstract><cop>Switzerland</cop><pmid>33916154</pmid><doi>10.3390/molecules26072016</doi></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biopsy Chromatography, High Pressure Liquid Cytokines - genetics Cytokines - metabolism Dermatitis, Atopic - drug therapy Dermatitis, Atopic - etiology Dermatitis, Atopic - metabolism Dermatitis, Atopic - pathology Dinitrochlorobenzene - adverse effects Disease Models, Animal Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Female Gene Expression Immunoglobulin E - blood Immunoglobulin E - immunology Interleukin-4 - metabolism Mice Mice, Hairless Molecular Structure Plant Extracts - chemistry Plant Extracts - pharmacology Treatment Outcome |
| title | Wikstroemia ganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice |
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