Reduced Synaptic Density in Patients with Lewy Body Dementia: An [11C]UCB‐J PET Imaging Study

ABSTRACT Background Patients with Parkinson's disease (PD) often develop dementia, but the underlying substrate is incompletely understood. Generalized synaptic degeneration may contribute to dysfunction and cognitive decline in Lewy body dementias, but in vivo evidence is lacking. Objective Th...

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Veröffentlicht in:	Movement disorders 2021-09, Vol.36 (9), p.2057-2065
Hauptverfasser:	Andersen, Katrine B., Hansen, Allan K., Damholdt, Malene F., Horsager, Jacob, Skjærbæk, Casper, Gottrup, Hanne, Klit, Henriette, Schacht, Anna Christina, Danielsen, Erik H., Brooks, David J., Borghammer, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Cognitive ability Degeneration Dementia Dementia disorders Executive function Frontal gyrus Lewy bodies Magnetic resonance imaging Movement disorders Neurodegenerative diseases Neuropsychology Parkinson's disease Parkinson's disease dementia [11C]UCB‐J PET synapse neuropsychology Positron emission tomography Substantia nigra Synapses Synaptic density
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