Integration of evidence across human and model organism studies: A meeting report
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperabi...
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| Veröffentlicht in: | Genes, brain and behavior brain and behavior, 2021-07, Vol.20 (6), p.e12738 |
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| creator | Palmer, Rohan H C Johnson, Emma C Won, Hyejung Polimanti, Renato Kapoor, Manav Chitre, Apurva Bogue, Molly A Benca-Bachman, Chelsie E Parker, Clarissa C Verma, Anurag Reynolds, Timothy Ernst, Jason Bray, Michael Kwon, Soo Bin Lai, Dongbing Quach, Bryan C Gaddis, Nathan C Saba, Laura Chen, Hao Hawrylycz, Michael Zhang, Shan Zhou, Yuan Mahaffey, Spencer Fischer, Christian Sanchez-Roige, Sandra Bandrowski, Anita Lu, Qing Shen, Li Philip, Vivek Gelernter, Joel Bierut, Laura J Hancock, Dana B Edenberg, Howard J Johnson, Eric O Nestler, Eric J Barr, Peter B Prins, Pjotr Smith, Desmond J Akbarian, Schahram Thorgeirsson, Thorgeir Walton, Dave Baker, Erich Jacobson, Daniel Palmer, Abraham A Miles, Michael Chesler, Elissa J Emerson, Jake Agrawal, Arpana Martone, Maryann Williams, Robert W |
| description | The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs. |
| doi_str_mv | 10.1111/gbb.12738 |
| format | Article |
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(ORNL), Oak Ridge, TN (United States)</creatorcontrib><description>The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.</description><identifier>ISSN: 1601-1848</identifier><identifier>ISSN: 1601-183X</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/gbb.12738</identifier><identifier>PMID: 33893716</identifier><language>eng</language><publisher>England: Wiley; International Behavioural and Neural Genetics Society</publisher><subject>BASIC BIOLOGICAL SCIENCES ; cross-species ; data integration ; drug abuse ; genomics ; GWAS ; model organisms ; multi-omic ; Review ; substance use disorders ; working group</subject><ispartof>Genes, brain and behavior, 2021-07, Vol.20 (6), p.e12738</ispartof><rights>2021 The Authors. 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(ORNL), Oak Ridge, TN (United States)</creatorcontrib><title>Integration of evidence across human and model organism studies: A meeting report</title><title>Genes, brain and behavior</title><addtitle>Genes Brain Behav</addtitle><description>The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. 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This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.</description><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>cross-species</subject><subject>data integration</subject><subject>drug abuse</subject><subject>genomics</subject><subject>GWAS</subject><subject>model organisms</subject><subject>multi-omic</subject><subject>Review</subject><subject>substance use disorders</subject><subject>working group</subject><issn>1601-1848</issn><issn>1601-183X</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkU1LxDAQhoMofh_8AxI86WHXpGnT1IOwiF-wIKIHbyFNpt1Im6xJKvjvra4uOpcZmId3XuZF6IiSKR3rvK3rKc1KJjbQLuWETqhgL5vrORc7aC_GV0LoyNBttMOYqFhJ-S56vHcJ2qCS9Q77BsO7NeA0YKWDjxEvhl45rJzBvTfQYR9a5WzscUyDsRAv8Az3AMm6FgdY-pAO0FajugiHP30fPd1cP1_dTeYPt_dXs_lE5yRLk9oQkitd1DUpKlI1zEAOwBmIPM8KTirR0NFjWRoGtGacK8OM5oabkmQF20eXK9XlUPdgNLgUVCeXwfYqfEivrPy_cXYhW_8uBeMFr8gocLIS8DFZGbVNoBfaOwc6SSpIQegXdPpzJfi3AWKSvY0auk458EOUWUFFluUr9GyFfv8tQLP2Qon8SkmOKcnvlEb2-K_5NfkbC_sEC0aN0Q</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Palmer, Rohan H C</creator><creator>Johnson, Emma C</creator><creator>Won, Hyejung</creator><creator>Polimanti, Renato</creator><creator>Kapoor, Manav</creator><creator>Chitre, Apurva</creator><creator>Bogue, Molly A</creator><creator>Benca-Bachman, Chelsie E</creator><creator>Parker, Clarissa C</creator><creator>Verma, Anurag</creator><creator>Reynolds, Timothy</creator><creator>Ernst, Jason</creator><creator>Bray, Michael</creator><creator>Kwon, Soo Bin</creator><creator>Lai, Dongbing</creator><creator>Quach, Bryan C</creator><creator>Gaddis, Nathan C</creator><creator>Saba, Laura</creator><creator>Chen, Hao</creator><creator>Hawrylycz, Michael</creator><creator>Zhang, Shan</creator><creator>Zhou, Yuan</creator><creator>Mahaffey, Spencer</creator><creator>Fischer, Christian</creator><creator>Sanchez-Roige, Sandra</creator><creator>Bandrowski, Anita</creator><creator>Lu, Qing</creator><creator>Shen, Li</creator><creator>Philip, Vivek</creator><creator>Gelernter, Joel</creator><creator>Bierut, Laura J</creator><creator>Hancock, Dana B</creator><creator>Edenberg, Howard J</creator><creator>Johnson, Eric O</creator><creator>Nestler, Eric J</creator><creator>Barr, Peter B</creator><creator>Prins, Pjotr</creator><creator>Smith, Desmond J</creator><creator>Akbarian, Schahram</creator><creator>Thorgeirsson, Thorgeir</creator><creator>Walton, Dave</creator><creator>Baker, Erich</creator><creator>Jacobson, Daniel</creator><creator>Palmer, Abraham A</creator><creator>Miles, Michael</creator><creator>Chesler, Elissa J</creator><creator>Emerson, Jake</creator><creator>Agrawal, Arpana</creator><creator>Martone, Maryann</creator><creator>Williams, Robert W</creator><general>Wiley; 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Johnson, Emma C ; Won, Hyejung ; Polimanti, Renato ; Kapoor, Manav ; Chitre, Apurva ; Bogue, Molly A ; Benca-Bachman, Chelsie E ; Parker, Clarissa C ; Verma, Anurag ; Reynolds, Timothy ; Ernst, Jason ; Bray, Michael ; Kwon, Soo Bin ; Lai, Dongbing ; Quach, Bryan C ; Gaddis, Nathan C ; Saba, Laura ; Chen, Hao ; Hawrylycz, Michael ; Zhang, Shan ; Zhou, Yuan ; Mahaffey, Spencer ; Fischer, Christian ; Sanchez-Roige, Sandra ; Bandrowski, Anita ; Lu, Qing ; Shen, Li ; Philip, Vivek ; Gelernter, Joel ; Bierut, Laura J ; Hancock, Dana B ; Edenberg, Howard J ; Johnson, Eric O ; Nestler, Eric J ; Barr, Peter B ; Prins, Pjotr ; Smith, Desmond J ; Akbarian, Schahram ; Thorgeirsson, Thorgeir ; Walton, Dave ; Baker, Erich ; Jacobson, Daniel ; Palmer, Abraham A ; Miles, Michael ; Chesler, Elissa J ; Emerson, Jake ; Agrawal, Arpana ; Martone, Maryann ; Williams, Robert W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-bd004ac5bb05909f3de4ee63e844256098f193777d3e1b366ad3dc6d6d70253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>cross-species</topic><topic>data integration</topic><topic>drug abuse</topic><topic>genomics</topic><topic>GWAS</topic><topic>model organisms</topic><topic>multi-omic</topic><topic>Review</topic><topic>substance use disorders</topic><topic>working group</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palmer, Rohan H C</creatorcontrib><creatorcontrib>Johnson, Emma C</creatorcontrib><creatorcontrib>Won, Hyejung</creatorcontrib><creatorcontrib>Polimanti, Renato</creatorcontrib><creatorcontrib>Kapoor, Manav</creatorcontrib><creatorcontrib>Chitre, Apurva</creatorcontrib><creatorcontrib>Bogue, Molly A</creatorcontrib><creatorcontrib>Benca-Bachman, Chelsie E</creatorcontrib><creatorcontrib>Parker, Clarissa C</creatorcontrib><creatorcontrib>Verma, Anurag</creatorcontrib><creatorcontrib>Reynolds, Timothy</creatorcontrib><creatorcontrib>Ernst, Jason</creatorcontrib><creatorcontrib>Bray, Michael</creatorcontrib><creatorcontrib>Kwon, Soo Bin</creatorcontrib><creatorcontrib>Lai, Dongbing</creatorcontrib><creatorcontrib>Quach, Bryan C</creatorcontrib><creatorcontrib>Gaddis, Nathan C</creatorcontrib><creatorcontrib>Saba, Laura</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>Hawrylycz, Michael</creatorcontrib><creatorcontrib>Zhang, Shan</creatorcontrib><creatorcontrib>Zhou, Yuan</creatorcontrib><creatorcontrib>Mahaffey, Spencer</creatorcontrib><creatorcontrib>Fischer, Christian</creatorcontrib><creatorcontrib>Sanchez-Roige, Sandra</creatorcontrib><creatorcontrib>Bandrowski, Anita</creatorcontrib><creatorcontrib>Lu, Qing</creatorcontrib><creatorcontrib>Shen, Li</creatorcontrib><creatorcontrib>Philip, Vivek</creatorcontrib><creatorcontrib>Gelernter, Joel</creatorcontrib><creatorcontrib>Bierut, Laura J</creatorcontrib><creatorcontrib>Hancock, Dana B</creatorcontrib><creatorcontrib>Edenberg, Howard J</creatorcontrib><creatorcontrib>Johnson, Eric O</creatorcontrib><creatorcontrib>Nestler, Eric J</creatorcontrib><creatorcontrib>Barr, Peter B</creatorcontrib><creatorcontrib>Prins, Pjotr</creatorcontrib><creatorcontrib>Smith, Desmond J</creatorcontrib><creatorcontrib>Akbarian, Schahram</creatorcontrib><creatorcontrib>Thorgeirsson, Thorgeir</creatorcontrib><creatorcontrib>Walton, Dave</creatorcontrib><creatorcontrib>Baker, Erich</creatorcontrib><creatorcontrib>Jacobson, Daniel</creatorcontrib><creatorcontrib>Palmer, Abraham A</creatorcontrib><creatorcontrib>Miles, Michael</creatorcontrib><creatorcontrib>Chesler, Elissa J</creatorcontrib><creatorcontrib>Emerson, Jake</creatorcontrib><creatorcontrib>Agrawal, Arpana</creatorcontrib><creatorcontrib>Martone, Maryann</creatorcontrib><creatorcontrib>Williams, Robert W</creatorcontrib><creatorcontrib>Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palmer, Rohan H C</au><au>Johnson, Emma C</au><au>Won, Hyejung</au><au>Polimanti, Renato</au><au>Kapoor, Manav</au><au>Chitre, Apurva</au><au>Bogue, Molly A</au><au>Benca-Bachman, Chelsie E</au><au>Parker, Clarissa C</au><au>Verma, Anurag</au><au>Reynolds, Timothy</au><au>Ernst, Jason</au><au>Bray, Michael</au><au>Kwon, Soo Bin</au><au>Lai, Dongbing</au><au>Quach, Bryan C</au><au>Gaddis, Nathan C</au><au>Saba, Laura</au><au>Chen, Hao</au><au>Hawrylycz, Michael</au><au>Zhang, Shan</au><au>Zhou, Yuan</au><au>Mahaffey, Spencer</au><au>Fischer, Christian</au><au>Sanchez-Roige, Sandra</au><au>Bandrowski, Anita</au><au>Lu, Qing</au><au>Shen, Li</au><au>Philip, Vivek</au><au>Gelernter, Joel</au><au>Bierut, Laura J</au><au>Hancock, Dana B</au><au>Edenberg, Howard J</au><au>Johnson, Eric O</au><au>Nestler, Eric J</au><au>Barr, Peter B</au><au>Prins, Pjotr</au><au>Smith, Desmond J</au><au>Akbarian, Schahram</au><au>Thorgeirsson, Thorgeir</au><au>Walton, Dave</au><au>Baker, Erich</au><au>Jacobson, Daniel</au><au>Palmer, Abraham A</au><au>Miles, Michael</au><au>Chesler, Elissa J</au><au>Emerson, Jake</au><au>Agrawal, Arpana</au><au>Martone, Maryann</au><au>Williams, Robert W</au><aucorp>Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integration of evidence across human and model organism studies: A meeting report</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>20</volume><issue>6</issue><spage>e12738</spage><pages>e12738-</pages><issn>1601-1848</issn><issn>1601-183X</issn><eissn>1601-183X</eissn><abstract>The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. 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| fulltext | fulltext |
| identifier | ISSN: 1601-1848 |
| ispartof | Genes, brain and behavior, 2021-07, Vol.20 (6), p.e12738 |
| issn | 1601-1848 1601-183X 1601-183X |
| language | eng |
| recordid | cdi_pubmed_primary_33893716 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley-Blackwell Open Access Titles; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | BASIC BIOLOGICAL SCIENCES cross-species data integration drug abuse genomics GWAS model organisms multi-omic Review substance use disorders working group |
| title | Integration of evidence across human and model organism studies: A meeting report |
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