Maternal smoking during pregnancy aggravated muscle phenotype in FHL1−/y offspring mice similar to congenital clubfoot through P2RX7-mediated pyroptosis

[Display omitted] •Maternal smoking aggravated muscle phenotype in FHL1−/y offspring mice.•P2RX7-mediated pyroptosis participated in aggravated muscle phenotype.•Cytoskeletal proteins-MYBPC2, LDB3 involved in aggravated muscle phenotype. Congenital clubfoot (CCF) is a common birth defect. Maternal s...

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Veröffentlicht in:	Toxicology letters 2021-07, Vol.345, p.54-60
Hauptverfasser:	Lou, Yi, Miao, Jianing, Li, Fang, Ding, Jingjing, Wang, Lili
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Carrier Proteins - metabolism Cigarette smoke Clubfoot - genetics Clubfoot - metabolism Clubfoot - pathology Congenital clubfoot Female FHL1 Gestational Age Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics LIM Domain Proteins - deficiency LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Male Maternal Exposure - adverse effects Mice Mice, Inbred C57BL Mice, Knockout Muscle Proteins - deficiency Muscle Proteins - genetics Muscle, Skeletal - metabolism Muscle, Skeletal - pathology MyoD Protein - metabolism P2RX7 Phenotype Pregnancy Prenatal Exposure Delayed Effects Pyroptosis Receptors, Purinergic P2X7 - metabolism Signal Transduction Skeletal muscle Smoking - adverse effects
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