LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss

Senescence of bone marrow-derived mesenchymal stem cells (BMSCs) has been widely reported to be closely correlated with aging-related diseases, including osteoporosis (OP). Moreover, the beneficial functions of BMSCs decline with age, limiting their therapeutic efficacy in OP. In the present study,...

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Veröffentlicht in:	Redox biology 2021-07, Vol.43, p.101963-101963, Article 101963
Hauptverfasser:	Liu, Fei, Yuan, Yujia, Bai, Lin, Yuan, Longhui, Li, Lan, Liu, Jingping, Chen, Younan, Lu, Yanrong, Cheng, Jingqiu, Zhang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biochemistry & Molecular Biology BMSCs Cell Differentiation Cellular Senescence Female Humans Intercellular Signaling Peptides and Proteins Life Sciences & Biomedicine LRRc17 Mesenchymal Stem Cells Mice Mitophagy Osteogenesis Osteoporosis Ovariectomy Phosphatidylinositol 3-Kinases Research Paper Science & Technology
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