A pan-cancer transcriptome analysis of exitron splicing identifies novel cancer driver genes and neoepitopes

Exitron splicing (EIS) creates a cryptic intron (called an exitron) within a protein-coding exon to increase proteome diversity. EIS is poorly characterized, but emerging evidence suggests a role for EIS in cancer. Through a systematic investigation of EIS across 33 cancers from 9,599 tumor transcri...

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Veröffentlicht in:	Molecular cell 2021-05, Vol.81 (10), p.2246-2260.e12
Hauptverfasser:	Wang, Ting-You, Liu, Qi, Ren, Yanan, Alam, Sk. Kayum, Wang, Li, Zhu, Zhu, Hoeppner, Luke H., Dehm, Scott M., Cao, Qi, Yang, Rendong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence cancer driver genes Cell Line checkpoint inhibition immunotherapy Cohort Studies Epitopes - genetics exitron Exons - genetics Gene Expression Profiling GTEx Humans immunopeptidome Introns - genetics Mutation - genetics neoantigens Neoplasms - genetics non-canonical splicing Oncogenes pan-cancer analysis RNA Splicing - genetics TCGA transcriptome alterations
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