Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2-5 times...

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Veröffentlicht in:	Drug delivery 2021-01, Vol.28 (1), p.767-775
Hauptverfasser:	Kuehl, Philip J., Yingling, Christin M., Dubose, Devon, Burke, Michael, Revelli, David A., Chen, Wenshu, Dye, Wendy W., Belinsky, Steven A., Tessema, Mathewos
Format:	Artikel
Sprache:	eng
Schlagworte:	aerosol Aerosols Cancer therapies Chemotherapy Drug dosages dry powder EGFR mutant FDA approval inhalation therapy KRAS Laboratories Lung cancer Mutation non-small cell lung cancer Pharmacokinetics Research centers Topoisomerase inhibitor Tumors
Online-Zugang:	Volltext
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