DNA analysis cervical and vaginal cancer cells during radiotherapy by rapid high-resolution cytometry
The DNA content of the nuclei of cancer cells of 12 cases of cervical cancer and 2 cases of vaginal cancer, treated with radiotherapy, were studied in 50 specimens. Specimens were taken from each case before radiotherapy and at the totals of 1,000 rad, 2,000 rad, 3,000 rad and 4,500 rad (or 5,000 ra...
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| Veröffentlicht in: | Nihon Sanka Fujinka Gakkai zasshi 1988-05, Vol.40 (5), p.621 |
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| container_title | Nihon Sanka Fujinka Gakkai zasshi |
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| creator | Izutsu, T Kagabu, T Nishiya, I Wied, G L |
| description | The DNA content of the nuclei of cancer cells of 12 cases of cervical cancer and 2 cases of vaginal cancer, treated with radiotherapy, were studied in 50 specimens. Specimens were taken from each case before radiotherapy and at the totals of 1,000 rad, 2,000 rad, 3,000 rad and 4,500 rad (or 5,000 rad). All specimens were stained by the Papanicolaou method and were analyzed by rapid high-resolution cytometry. Total optical density, mean nuclear area and the 5N-exceeding rate (5NER) increased gradually following irradiation. Cancer cells disappeared in good response cases before 3,000 rad. Eight smears with a 5NER under 100 at the dose of 3,000 rad or more seemed to be poor response cases. Low 5NER and low mean nuclear areas were observed in both patients who died with persistent disease after radiotherapy, as well as in one case treated with chemotherapy for persistent disease after radiotherapy. |
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Specimens were taken from each case before radiotherapy and at the totals of 1,000 rad, 2,000 rad, 3,000 rad and 4,500 rad (or 5,000 rad). All specimens were stained by the Papanicolaou method and were analyzed by rapid high-resolution cytometry. Total optical density, mean nuclear area and the 5N-exceeding rate (5NER) increased gradually following irradiation. Cancer cells disappeared in good response cases before 3,000 rad. Eight smears with a 5NER under 100 at the dose of 3,000 rad or more seemed to be poor response cases. 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Specimens were taken from each case before radiotherapy and at the totals of 1,000 rad, 2,000 rad, 3,000 rad and 4,500 rad (or 5,000 rad). All specimens were stained by the Papanicolaou method and were analyzed by rapid high-resolution cytometry. Total optical density, mean nuclear area and the 5N-exceeding rate (5NER) increased gradually following irradiation. Cancer cells disappeared in good response cases before 3,000 rad. Eight smears with a 5NER under 100 at the dose of 3,000 rad or more seemed to be poor response cases. Low 5NER and low mean nuclear areas were observed in both patients who died with persistent disease after radiotherapy, as well as in one case treated with chemotherapy for persistent disease after radiotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - analysis</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>DNA, Neoplasm - analysis</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Radiotherapy Dosage</subject><subject>Uterine Cervical Neoplasms - analysis</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><subject>Vaginal Neoplasms - analysis</subject><subject>Vaginal Neoplasms - radiotherapy</subject><issn>0300-9165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj8tqwzAURLVoSUOaTyjoBwyybmXZy5A-IaSbdh2uXrZAfiDZAf19XZrVMHNg4NyRLQPGiqasxAPZp-QVY6KWjRTPG7IBqAWv2ZbYl_OB4oAhJ5-otvHqNYZ1MfSKrV8B1Tis-8pCSNQs0Q8tjWj8OHc24pSpymufvKGdb7si2jSGZfbjQHWex97OMT-Se4ch2f0td-Tn7fX7-FGcvt4_j4dTMZW8nAtrJBguK-0ax7mUoJWuygoQoAFhlbZOScXxT6JytVSghLZNyUAZp1HBjjz9_06L6q25TNH3GPPlpgu_7ylTzw</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Izutsu, T</creator><creator>Kagabu, T</creator><creator>Nishiya, I</creator><creator>Wied, G L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198805</creationdate><title>DNA analysis cervical and vaginal cancer cells during radiotherapy by rapid high-resolution cytometry</title><author>Izutsu, T ; Kagabu, T ; Nishiya, I ; Wied, G L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-ed73d276cf9f22773cbc6163a33935ebcefb7b2a97546f87b3b5ce9103bdfcab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - analysis</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>DNA, Neoplasm - analysis</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Radiotherapy Dosage</topic><topic>Uterine Cervical Neoplasms - analysis</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><topic>Vaginal Neoplasms - analysis</topic><topic>Vaginal Neoplasms - radiotherapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Izutsu, T</creatorcontrib><creatorcontrib>Kagabu, T</creatorcontrib><creatorcontrib>Nishiya, I</creatorcontrib><creatorcontrib>Wied, G L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nihon Sanka Fujinka Gakkai zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izutsu, T</au><au>Kagabu, T</au><au>Nishiya, I</au><au>Wied, G L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA analysis cervical and vaginal cancer cells during radiotherapy by rapid high-resolution cytometry</atitle><jtitle>Nihon Sanka Fujinka Gakkai zasshi</jtitle><addtitle>Nihon Sanka Fujinka Gakkai Zasshi</addtitle><date>1988-05</date><risdate>1988</risdate><volume>40</volume><issue>5</issue><spage>621</spage><pages>621-</pages><issn>0300-9165</issn><abstract>The DNA content of the nuclei of cancer cells of 12 cases of cervical cancer and 2 cases of vaginal cancer, treated with radiotherapy, were studied in 50 specimens. 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| ispartof | Nihon Sanka Fujinka Gakkai zasshi, 1988-05, Vol.40 (5), p.621 |
| issn | 0300-9165 |
| language | eng |
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| source | MEDLINE; Freely Accessible Japanese Titles |
| subjects | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - analysis Carcinoma, Squamous Cell - radiotherapy DNA, Neoplasm - analysis Dose-Response Relationship, Radiation Female Flow Cytometry Humans Middle Aged Predictive Value of Tests Radiotherapy Dosage Uterine Cervical Neoplasms - analysis Uterine Cervical Neoplasms - radiotherapy Vaginal Neoplasms - analysis Vaginal Neoplasms - radiotherapy |
| title | DNA analysis cervical and vaginal cancer cells during radiotherapy by rapid high-resolution cytometry |
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