Basmisanil, a highly selective GABA A -α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

GABA -α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinical profile of a novel GABA -α5 selective negative allosteric...

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Veröffentlicht in:	Scientific reports 2021-04, Vol.11 (1), p.7700
Hauptverfasser:	Hipp, Joerg F, Knoflach, Frederic, Comley, Robert, Ballard, Theresa M, Honer, Michael, Trube, Gerhard, Gasser, Rodolfo, Prinssen, Eric, Wallace, Tanya L, Rothfuss, Andreas, Knust, Henner, Lennon-Chrimes, Sian, Derks, Michael, Bentley, Darren, Squassante, Lisa, Nave, Stephane, Nöldeke, Jana, Wandel, Christoph, Thomas, Andrew W, Hernandez, Maria-Clemencia
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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