Ramatroban-Based Analogues Containing Fluorine Group as Potential 18 F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers

Diabetes remains one of the fastest growing chronic diseases and is a leading source of morbidity and accelerated mortality in the world. Loss of beta cell mass (BCM) and decreased sensitivity to insulin underlie diabetes pathogenesis. Yet, the ability to safely and directly assess BCM in individual...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-03, Vol.26 (5)
Hauptverfasser:	Huang, Lina A, Huang, Kelly X, Tu, Jui, Kandeel, Fouad, Li, Junfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbazoles - chemistry Fluorine Radioisotopes - metabolism Humans Insulin-Secreting Cells - chemistry Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Platelet Aggregation Inhibitors - chemistry Positron-Emission Tomography - methods Radioactive Tracers Radiopharmaceuticals - metabolism Receptors, Immunologic - metabolism Receptors, Prostaglandin - metabolism Sulfonamides - chemistry
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