A Dual Target-Directed Single Domain-Based Fusion Protein Against Interleukin-6 Receptor Decelerate Experimental Arthritis Progression Via Modulating JNK Expression

The currently used anti-cytokine therapeutic antibodies cannot selectively neutralize pathogenic cytokine signalling that cause collateral damage to protective signalling cascades. The single domain chain firstly discovered in Camelidae displays fully functional ability in antigen-binding against va...

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Veröffentlicht in:	Inflammation 2021-08, Vol.44 (4), p.1620-1628
Hauptverfasser:	Chen, Xiaole, Bian, Yize, Xie, Yongqing, Zheng, Ningning, Nie, Kaimei, Liu, Rui, Yan, Mengru, Luo, Hongbin, Wang, He, Yang, Juhua, Zhang, Nanwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Biomedical and Life Sciences Biomedicine Cell Biology Cytokines Dexamethasone Fusion protein Immunology Inflammation Interleukin 6 Internal Medicine JNK protein Life Sciences & Biomedicine Lipopolysaccharides Original Original Article Pathology Pharmacology/Toxicology Proteins Rheumatology Science & Technology
Online-Zugang:	Volltext
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