FTO-mediated cytoplasmic m 6 A m demethylation adjusts stem-like properties in colorectal cancer cell

Cancer stem cells (CSCs) are a small but critical cell population for cancer biology since they display inherent resistance to standard therapies and give rise to metastases. Despite accruing evidence establishing a link between deregulation of epitranscriptome-related players and tumorigenic proces...

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Veröffentlicht in:	Nature communications 2021-03, Vol.12 (1), p.1716
Hauptverfasser:	Relier, Sébastien, Ripoll, Julie, Guillorit, Hélène, Amalric, Amandine, Achour, Cyrinne, Boissière, Florence, Vialaret, Jérôme, Attina, Aurore, Debart, Françoise, Choquet, Armelle, Macari, Françoise, Marchand, Virginie, Motorin, Yuri, Samalin, Emmanuelle, Vasseur, Jean-Jacques, Pannequin, Julie, Aguilo, Francesca, Lopez-Crapez, Evelyne, Hirtz, Christophe, Rivals, Eric, Bastide, Amandine, David, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adenosine - metabolism Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism Cell Line, Tumor Cell Nucleus - metabolism Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cytoplasm - metabolism Demethylation Gene Expression Regulation, Neoplastic Gene Silencing Humans Methyltransferases - metabolism Nuclear Proteins - metabolism RNA, Messenger - metabolism
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