Elevated levels of mitochondrial CoQ 10 induce ROS-mediated apoptosis in pancreatic cancer

Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for targeting ROS pathways for effective anti-cancer therapeutics. Coenzyme Q is a critical cof...

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Veröffentlicht in:	Scientific reports 2021-03, Vol.11 (1), p.5749
Hauptverfasser:	Dadali, Tulin, Diers, Anne R, Kazerounian, Shiva, Muthuswamy, Senthil K, Awate, Pallavi, Ng, Ryan, Mogre, Saie, Spencer, Carrie, Krumova, Katerina, Rockwell, Hannah E, McDaniel, Justice, Chen, Emily Y, Gao, Fei, Diedrich, Karl T, Vemulapalli, Vijetha, Rodrigues, Leonardo O, Akmaev, Viatcheslav R, Thapa, Khampaseuth, Hidalgo, Manuel, Bose, Arindam, Vishnudas, Vivek K, Moser, A James, Granger, Elder, Kiebish, Michael A, Gesta, Stephane, Narain, Niven R, Sarangarajan, Rangaprasad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Line, Tumor Cell Proliferation Cell Respiration Cell Survival Electron Transport Complex II - metabolism Glycerol-3-Phosphate Dehydrogenase (NAD+) Humans Membrane Potential, Mitochondrial Mice Mice, Nude Mitochondria - metabolism Organoids - pathology Oxidative Stress Oxygen Consumption Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Reactive Oxygen Species - metabolism Substrate Specificity Ubiquinone - analogs & derivatives Ubiquinone - metabolism
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