Novel Negative Sense Genes in the RNA Genome of Coronaviruses
The coronavirus family consists of lipid-containing envelope viruses that have a single-stranded RNA genome that encodes 25–30 proteins in different viruses by the mechanism of positive-polarity strategy. In addition, extended open reading trnslation frames (ORFs, genes) located in a negative-sense...
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| Veröffentlicht in: | Doklady. Biochemistry and biophysics 2021-05, Vol.496 (1), p.27-31 |
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| container_title | Doklady. Biochemistry and biophysics |
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| creator | Zhirnov, O. P. Poyarkov, S. V. |
| description | The coronavirus family consists of lipid-containing envelope viruses that have a single-stranded RNA genome that encodes 25–30 proteins in different viruses by the mechanism of positive-polarity strategy. In addition, extended open reading trnslation frames (ORFs, genes) located in a negative-sense orientation were found in the genomes of coronaviruses. The size of negative-sense genes varies in the range of 150–450 nt, which corresponds to polypeptides encoded by negative-polarity genes (negative gene proteins, NGP) with m. m. 5–30 × 10
3
kDa. Coronaviruses show marked differences from virus to virus in the number of negative genes detected. These negative-sense genes in the coronavirus genome allow this family to be considered as viruses developing an ambisense genome strategy. |
| doi_str_mv | 10.1134/S1607672921010130 |
| format | Article |
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kDa. Coronaviruses show marked differences from virus to virus in the number of negative genes detected. 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| subjects | Base Sequence Biochemistry Biochemistry & Molecular Biology Biochemistry, Biophysics, and Molecular Biology Biological and Medical Physics Biomedical and Life Sciences Biophysics Coronaviridae Coronaviruses Genes, Viral - genetics Genomes Genomics Life Sciences Life Sciences & Biomedicine Molecular Biology Open Reading Frames - genetics Polarity RNA, Viral - genetics SARS-CoV-2 - genetics Science & Technology Viruses |
| title | Novel Negative Sense Genes in the RNA Genome of Coronaviruses |
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