Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna
Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy....
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| creator | Segura Félix, Kristian Guerrero López, Geshel D. Cepeda Rubio, Mario F. J. Hernández Jacquez, José I. Flores García, Francisco G. Hernández, Arturo Vera Salas, Lorenzo Leija Orozco Ruiz de la Peña, Eva C. |
| description | Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy. Recently, different minimally invasive technologies have been applied (e.g., emission of electromagnetic waves, thermal and chemical means) to overcome the important side effects of these treatment modalities. The objective of this study was to develop and evaluate a predictive computational model of microwave ablation. Materials and Methods. The predictive computational model of microwave ablation was constructed by means of a dual-slot coaxial antenna. The model was compared with an experiment performed using a breast phantom, which emulates the dielectric properties of breast tissue with segmental microcalcifications. The standing wave ratio (SWR) was obtained for both methods to make a comparison and determine the feasibility of applying electromagnetic ablation to premalignant lesions in breasts. Specifically, for the analysis of segmental microcalcifications, a breast phantom with segmental microcalcifications was developed and two computational models were performed under the same conditions (except for blood perfusion, which was excluded in one of the models). Results. The SWR was obtained by triplicate experiments in the phantom, and the measurements had a difference of 0.191 between the minimum and maximum SWR values, implying a change of power reflection of 0.8%. The average of the three measurements was compared with the simulation that did not consider blood perfusion. The comparison yielded a change of 0.104, representing a 0.2% change in power reflection. Discussion. Both experimentation in phantom and simulations demonstrated that ablation therapy can be performed using this antenna. However, an additional optimization procedure is warranted to increase the efficiency of the antenna. |
| doi_str_mv | 10.1155/2021/8858822 |
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J. ; Hernández Jacquez, José I. ; Flores García, Francisco G. ; Hernández, Arturo Vera ; Salas, Lorenzo Leija ; Orozco Ruiz de la Peña, Eva C.</creator><contributor>Ta, Dean ; Dean Ta</contributor><creatorcontrib>Segura Félix, Kristian ; Guerrero López, Geshel D. ; Cepeda Rubio, Mario F. J. ; Hernández Jacquez, José I. ; Flores García, Francisco G. ; Hernández, Arturo Vera ; Salas, Lorenzo Leija ; Orozco Ruiz de la Peña, Eva C. ; Ta, Dean ; Dean Ta</creatorcontrib><description>Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy. Recently, different minimally invasive technologies have been applied (e.g., emission of electromagnetic waves, thermal and chemical means) to overcome the important side effects of these treatment modalities. The objective of this study was to develop and evaluate a predictive computational model of microwave ablation. Materials and Methods. The predictive computational model of microwave ablation was constructed by means of a dual-slot coaxial antenna. The model was compared with an experiment performed using a breast phantom, which emulates the dielectric properties of breast tissue with segmental microcalcifications. The standing wave ratio (SWR) was obtained for both methods to make a comparison and determine the feasibility of applying electromagnetic ablation to premalignant lesions in breasts. Specifically, for the analysis of segmental microcalcifications, a breast phantom with segmental microcalcifications was developed and two computational models were performed under the same conditions (except for blood perfusion, which was excluded in one of the models). Results. The SWR was obtained by triplicate experiments in the phantom, and the measurements had a difference of 0.191 between the minimum and maximum SWR values, implying a change of power reflection of 0.8%. The average of the three measurements was compared with the simulation that did not consider blood perfusion. The comparison yielded a change of 0.104, representing a 0.2% change in power reflection. Discussion. Both experimentation in phantom and simulations demonstrated that ablation therapy can be performed using this antenna. However, an additional optimization procedure is warranted to increase the efficiency of the antenna.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/8858822</identifier><identifier>PMID: 33688503</identifier><language>eng</language><publisher>LONDON: Hindawi</publisher><subject>Ablation ; Ablative materials ; Antennas ; Asymptomatic ; Biotechnology & Applied Microbiology ; Blood ; Breast cancer ; Breast Neoplasms - therapy ; Calcinosis - therapy ; Cancer therapies ; Chemotherapy ; Computer applications ; Dielectric properties ; Electrical properties ; Electromagnetic radiation ; Experimentation ; Female ; Heat ; Humans ; Life Sciences & Biomedicine ; Mammography ; Mathematical models ; Medical treatment ; Medicine, Research & Experimental ; Microwave ablation ; Models, Biological ; Morphology ; Optimization ; Perfusion ; Phantoms, Imaging ; Radiation therapy ; Radiofrequency Ablation ; Research & Experimental Medicine ; Science & Technology ; Side effects ; Slot antennas ; Standing wave ratios ; Tissues</subject><ispartof>BioMed research international, 2021, Vol.2021, p.8858822-10, Article 8858822</ispartof><rights>Copyright © 2021 Kristian Segura Félix et al.</rights><rights>Copyright © 2021 Kristian Segura Félix et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Kristian Segura Félix et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>4</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000627369100004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c448t-f59ff9b147a6bc55e3ebd292d6964864b9d2fcd14dce18e14100da4dbb7807f73</citedby><cites>FETCH-LOGICAL-c448t-f59ff9b147a6bc55e3ebd292d6964864b9d2fcd14dce18e14100da4dbb7807f73</cites><orcidid>0000-0003-0341-501X ; 0000-0001-8437-6520 ; 0000-0002-0820-5620 ; 0000-0003-0310-0712 ; 0000-0001-6258-154X ; 0000-0002-6661-8191 ; 0000-0001-9274-8208 ; 0000-0002-5590-9735</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920705/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920705/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,27928,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33688503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ta, Dean</contributor><contributor>Dean Ta</contributor><creatorcontrib>Segura Félix, Kristian</creatorcontrib><creatorcontrib>Guerrero López, Geshel D.</creatorcontrib><creatorcontrib>Cepeda Rubio, Mario F. J.</creatorcontrib><creatorcontrib>Hernández Jacquez, José I.</creatorcontrib><creatorcontrib>Flores García, Francisco G.</creatorcontrib><creatorcontrib>Hernández, Arturo Vera</creatorcontrib><creatorcontrib>Salas, Lorenzo Leija</creatorcontrib><creatorcontrib>Orozco Ruiz de la Peña, Eva C.</creatorcontrib><title>Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna</title><title>BioMed research international</title><addtitle>BIOMED RES INT-UK</addtitle><addtitle>Biomed Res Int</addtitle><description>Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy. Recently, different minimally invasive technologies have been applied (e.g., emission of electromagnetic waves, thermal and chemical means) to overcome the important side effects of these treatment modalities. The objective of this study was to develop and evaluate a predictive computational model of microwave ablation. Materials and Methods. The predictive computational model of microwave ablation was constructed by means of a dual-slot coaxial antenna. The model was compared with an experiment performed using a breast phantom, which emulates the dielectric properties of breast tissue with segmental microcalcifications. The standing wave ratio (SWR) was obtained for both methods to make a comparison and determine the feasibility of applying electromagnetic ablation to premalignant lesions in breasts. Specifically, for the analysis of segmental microcalcifications, a breast phantom with segmental microcalcifications was developed and two computational models were performed under the same conditions (except for blood perfusion, which was excluded in one of the models). Results. The SWR was obtained by triplicate experiments in the phantom, and the measurements had a difference of 0.191 between the minimum and maximum SWR values, implying a change of power reflection of 0.8%. The average of the three measurements was compared with the simulation that did not consider blood perfusion. The comparison yielded a change of 0.104, representing a 0.2% change in power reflection. Discussion. Both experimentation in phantom and simulations demonstrated that ablation therapy can be performed using this antenna. However, an additional optimization procedure is warranted to increase the efficiency of the antenna.</description><subject>Ablation</subject><subject>Ablative materials</subject><subject>Antennas</subject><subject>Asymptomatic</subject><subject>Biotechnology & Applied Microbiology</subject><subject>Blood</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - therapy</subject><subject>Calcinosis - therapy</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Computer applications</subject><subject>Dielectric properties</subject><subject>Electrical properties</subject><subject>Electromagnetic radiation</subject><subject>Experimentation</subject><subject>Female</subject><subject>Heat</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Mammography</subject><subject>Mathematical models</subject><subject>Medical treatment</subject><subject>Medicine, Research & Experimental</subject><subject>Microwave ablation</subject><subject>Models, Biological</subject><subject>Morphology</subject><subject>Optimization</subject><subject>Perfusion</subject><subject>Phantoms, Imaging</subject><subject>Radiation therapy</subject><subject>Radiofrequency Ablation</subject><subject>Research & Experimental Medicine</subject><subject>Science & Technology</subject><subject>Side effects</subject><subject>Slot antennas</subject><subject>Standing wave ratios</subject><subject>Tissues</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0ktv1DAQAOAIgWhVeuOMLHFBgqV-JbEvSEtoAakrkEq5Ro4fu64ce4mdLv0h_b94N8vyOCB8ieV8mXFmpiieIvgaobI8wxCjM8ZKxjB-UBxjguisQhQ9POwJOSpOY7yBeTFUQV49Lo4IqfJHkBwX903o12MSyQYvHLg4X4BFUNoB4RX4vBI-hR58Fc6qHQHBgIWVQ9iIWw3mnZtOTRjAlV722qccZAekcNIaK3cgAuvB20GLmCK4jtYvgQBNEN9t5u_C2Dk9u3IhgblP2nvxpHhkhIv6dP88Ka4vzr80H2aXn95_bOaXM0kpSzNTcmN4h2gtqk6WpSa6U5hjVfGKsop2XGEjFaJKasR0rguESlDVdTWDtanJSfFmirseu15n5dMgXLsebC-GuzYI2_75xttVuwy3bc0xrGGZA7zYBxjCt1HH1PY2Su2c8DqMscWUc05yXp7p87_oTRiHXPSdqhmjNWJZvZpULmGMgzaHyyDYblveblve7lue-bPff-CAfzY4g5cT2OgumCit9lIfWJ6JCtek4mg7HjRr9v-6sdPYNGH06VeilfVKbOy_7_0DrkjWXw</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Segura Félix, Kristian</creator><creator>Guerrero López, Geshel D.</creator><creator>Cepeda Rubio, Mario F. 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J.</au><au>Hernández Jacquez, José I.</au><au>Flores García, Francisco G.</au><au>Hernández, Arturo Vera</au><au>Salas, Lorenzo Leija</au><au>Orozco Ruiz de la Peña, Eva C.</au><au>Ta, Dean</au><au>Dean Ta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna</atitle><jtitle>BioMed research international</jtitle><stitle>BIOMED RES INT-UK</stitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>8858822</spage><epage>10</epage><pages>8858822-10</pages><artnum>8858822</artnum><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy. Recently, different minimally invasive technologies have been applied (e.g., emission of electromagnetic waves, thermal and chemical means) to overcome the important side effects of these treatment modalities. The objective of this study was to develop and evaluate a predictive computational model of microwave ablation. Materials and Methods. The predictive computational model of microwave ablation was constructed by means of a dual-slot coaxial antenna. The model was compared with an experiment performed using a breast phantom, which emulates the dielectric properties of breast tissue with segmental microcalcifications. The standing wave ratio (SWR) was obtained for both methods to make a comparison and determine the feasibility of applying electromagnetic ablation to premalignant lesions in breasts. Specifically, for the analysis of segmental microcalcifications, a breast phantom with segmental microcalcifications was developed and two computational models were performed under the same conditions (except for blood perfusion, which was excluded in one of the models). Results. The SWR was obtained by triplicate experiments in the phantom, and the measurements had a difference of 0.191 between the minimum and maximum SWR values, implying a change of power reflection of 0.8%. The average of the three measurements was compared with the simulation that did not consider blood perfusion. The comparison yielded a change of 0.104, representing a 0.2% change in power reflection. Discussion. Both experimentation in phantom and simulations demonstrated that ablation therapy can be performed using this antenna. However, an additional optimization procedure is warranted to increase the efficiency of the antenna.</abstract><cop>LONDON</cop><pub>Hindawi</pub><pmid>33688503</pmid><doi>10.1155/2021/8858822</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0341-501X</orcidid><orcidid>https://orcid.org/0000-0001-8437-6520</orcidid><orcidid>https://orcid.org/0000-0002-0820-5620</orcidid><orcidid>https://orcid.org/0000-0003-0310-0712</orcidid><orcidid>https://orcid.org/0000-0001-6258-154X</orcidid><orcidid>https://orcid.org/0000-0002-6661-8191</orcidid><orcidid>https://orcid.org/0000-0001-9274-8208</orcidid><orcidid>https://orcid.org/0000-0002-5590-9735</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Ablation Ablative materials Antennas Asymptomatic Biotechnology & Applied Microbiology Blood Breast cancer Breast Neoplasms - therapy Calcinosis - therapy Cancer therapies Chemotherapy Computer applications Dielectric properties Electrical properties Electromagnetic radiation Experimentation Female Heat Humans Life Sciences & Biomedicine Mammography Mathematical models Medical treatment Medicine, Research & Experimental Microwave ablation Models, Biological Morphology Optimization Perfusion Phantoms, Imaging Radiation therapy Radiofrequency Ablation Research & Experimental Medicine Science & Technology Side effects Slot antennas Standing wave ratios Tissues |
| title | Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T06%3A22%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Computational%20FEM%20Model%20and%20Phantom%20Validation%20of%20Microwave%20Ablation%20for%20Segmental%20Microcalcifications%20in%20Breasts%20Using%20a%20Coaxial%20Double-Slot%20Antenna&rft.jtitle=BioMed%20research%20international&rft.au=Segura%20F%C3%A9lix,%20Kristian&rft.date=2021&rft.volume=2021&rft.spage=8858822&rft.epage=10&rft.pages=8858822-10&rft.artnum=8858822&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2021/8858822&rft_dat=%3Cproquest_pubme%3E2497884718%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2497884718&rft_id=info:pmid/33688503&rfr_iscdi=true |