Automatic Acetowhite Lesion Segmentation via Specular Reflection Removal and Deep Attention Network

Automatic acetowhite lesion segmentation in colposcopy images (cervigrams) is essential in assisting gynecologists for the diagnosis of cervical intraepithelial neoplasia grades and cervical cancer. It can also help gynecologists determine the correct lesion areas for further pathological examination. Existing computer-aided diagnosis algorithms show poor segmentation performance because of specular reflections, insufficient training data and the inability to focus on semantically meaningful lesion parts. In this paper, a novel computer-aided diagnosis algorithm is proposed to segment acetowhite lesions in cervigrams automatically. To reduce the interference of specularities on segmentation performance, a specular reflection removal mechanism is presented to detect and inpaint these areas with precision. Moreover, we design a cervigram image classification network to classify pathology results and generate lesion attention maps, which are subsequently leveraged to guide a more accurate lesion segmentation task by the proposed lesion-aware convolutional neural network. We conducted comprehensive experiments to evaluate the proposed approaches on 3045 clinical cervigrams. Our results show that our method outperforms state-of-the-art approaches and achieves better Dice similarity coefficient and Hausdorff Distance values in acetowhite legion segmentation.