Sympathetic nerve distribution in human lymph nodes
Various lymph node functions are regulated by the sympathetic nervous system as shown in rodent studies. If human lymph nodes show a comparable neural regulation, their afferent nerves could represent a potential therapeutic target to treat, for example, infectious or autoimmune disease. Little info...
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description | Various lymph node functions are regulated by the sympathetic nervous system as shown in rodent studies. If human lymph nodes show a comparable neural regulation, their afferent nerves could represent a potential therapeutic target to treat, for example, infectious or autoimmune disease. Little information is available on human lymph node innervation and the aim of this study is to establish a comprehensive and accurate representation of the presence and location of sympathetic nerves in human lymph nodes. Since previous studies mention sympathetic paravascular nerves to occasionally extent into T cell‐rich regions, the relation of these nerves with T cells was studied as well. A total number of 15 inguinal lymph nodes were resected from six donated human cadavers. Lymph node sections were stained with HE and a double T/B cell staining for evaluation of their morphology and to screen for general pathologies. A triple stain was used to identify blood vessels, sympathetic nerves and T cells, and, to study the presence and location of sympathetic nerves and their relation to T cells. To evaluate whether the observed nerves were en route to other structures or were involved in local processes, adjacent slides were stained with a marker for varicosities (synaptophysin), which presence is suggestive for synaptic activity. All lymph nodes contained sympathetic nerves, both as paravascular and discrete structures. In 15/15 lymph nodes, nerves were observed in their capsule, medulla and hilum, whereas only 13/15 lymph nodes contained nerves in their cortex. The amount of sympathetic nerves varied between compartments and between and within individuals. In general, if a lymph node contained more paravascular nerves in a specific compartment, more discrete nerves were observed as well. Occasionally, discrete nerves were observed in relation to T cells in lymphoid tissues of the cortex and medulla. Furthermore, discrete nerves were frequently present in the capsule and hilum. The presence of varicosities in a portion of these nerves, independently to their compartment, suggested a local regulatory function for these nerves. Human lymph nodes contain sympathetic nerves in their capsule, trabeculae, cortex, medulla and hilum, both as paravascular or as discrete structures. Discrete nerves were observed in relation to T cells and non‐T cell‐rich areas such as the hilar and capsular connective tissue. The presence of discrete structures suggests neural regulation of struc |
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Human lymph nodes contain a significant number of sympathetic nerves (black encircled, pink stained TH positive structures). These nerves can be observed surrounding vascular structures, but also as discrete entities in the capsule, cortex, medulla and hilum. In the medulla, these nerves are frequently observed in proximity with immune cells such as T lymphocytes (CD3 positive cells as shown in the right images). Sympathetic nerves in lymph nodes might contribute to neuro immune regulation of lymph node immune function.</description><identifier>ISSN: 0021-8782</identifier><identifier>EISSN: 1469-7580</identifier><identifier>DOI: 10.1111/joa.13422</identifier><identifier>PMID: 33677834</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>adrenergic innervation ; Anatomy & Morphology ; Autoimmune diseases ; Blood vessels ; Brief Communication ; Cadavers ; Connective tissues ; Cortex ; Cytology ; Innervation ; Life Sciences & Biomedicine ; lymph node ; Lymph nodes ; Lymphatic system ; Lymphocytes ; Lymphocytes T ; Lymphoid tissue ; Medulla oblongata ; neuroimmune regulation ; Science & Technology ; Sensory neurons ; sympathetic innervation ; Sympathetic nerves ; Sympathetic nervous system ; Synaptophysin</subject><ispartof>Journal of anatomy, 2021-08, Vol.239 (2), p.282-289</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of Anatomical Society.</rights><rights>2021 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>21</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000625729900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c5092-3d48254d23b48a3406c4a4baea31150fdc7592a5728b401195e936e7d847e1443</citedby><cites>FETCH-LOGICAL-c5092-3d48254d23b48a3406c4a4baea31150fdc7592a5728b401195e936e7d847e1443</cites><orcidid>0000-0003-4993-3736</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273593/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273593/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,1419,1435,27931,27932,39265,45581,45582,46416,46840,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33677834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cleypool, Cindy G. J.</creatorcontrib><creatorcontrib>Mackaaij, Claire</creatorcontrib><creatorcontrib>Lotgerink Bruinenberg, Dyonne</creatorcontrib><creatorcontrib>Schurink, Bernadette</creatorcontrib><creatorcontrib>Bleys, Ronald L. A. W.</creatorcontrib><title>Sympathetic nerve distribution in human lymph nodes</title><title>Journal of anatomy</title><addtitle>J ANAT</addtitle><addtitle>J Anat</addtitle><description>Various lymph node functions are regulated by the sympathetic nervous system as shown in rodent studies. If human lymph nodes show a comparable neural regulation, their afferent nerves could represent a potential therapeutic target to treat, for example, infectious or autoimmune disease. Little information is available on human lymph node innervation and the aim of this study is to establish a comprehensive and accurate representation of the presence and location of sympathetic nerves in human lymph nodes. Since previous studies mention sympathetic paravascular nerves to occasionally extent into T cell‐rich regions, the relation of these nerves with T cells was studied as well. A total number of 15 inguinal lymph nodes were resected from six donated human cadavers. Lymph node sections were stained with HE and a double T/B cell staining for evaluation of their morphology and to screen for general pathologies. A triple stain was used to identify blood vessels, sympathetic nerves and T cells, and, to study the presence and location of sympathetic nerves and their relation to T cells. To evaluate whether the observed nerves were en route to other structures or were involved in local processes, adjacent slides were stained with a marker for varicosities (synaptophysin), which presence is suggestive for synaptic activity. All lymph nodes contained sympathetic nerves, both as paravascular and discrete structures. In 15/15 lymph nodes, nerves were observed in their capsule, medulla and hilum, whereas only 13/15 lymph nodes contained nerves in their cortex. The amount of sympathetic nerves varied between compartments and between and within individuals. In general, if a lymph node contained more paravascular nerves in a specific compartment, more discrete nerves were observed as well. Occasionally, discrete nerves were observed in relation to T cells in lymphoid tissues of the cortex and medulla. Furthermore, discrete nerves were frequently present in the capsule and hilum. The presence of varicosities in a portion of these nerves, independently to their compartment, suggested a local regulatory function for these nerves. Human lymph nodes contain sympathetic nerves in their capsule, trabeculae, cortex, medulla and hilum, both as paravascular or as discrete structures. Discrete nerves were observed in relation to T cells and non‐T cell‐rich areas such as the hilar and capsular connective tissue. The presence of discrete structures suggests neural regulation of structures other than blood vessels, which was further supported by the presence of varicosities in a portion of these nerves. These observations are of relevance in further understanding neural regulation of lymph node immune responses and in the development of neuromodulatory immune therapies.
Human lymph nodes contain a significant number of sympathetic nerves (black encircled, pink stained TH positive structures). These nerves can be observed surrounding vascular structures, but also as discrete entities in the capsule, cortex, medulla and hilum. In the medulla, these nerves are frequently observed in proximity with immune cells such as T lymphocytes (CD3 positive cells as shown in the right images). Sympathetic nerves in lymph nodes might contribute to neuro immune regulation of lymph node immune function.</description><subject>adrenergic innervation</subject><subject>Anatomy & Morphology</subject><subject>Autoimmune diseases</subject><subject>Blood vessels</subject><subject>Brief Communication</subject><subject>Cadavers</subject><subject>Connective tissues</subject><subject>Cortex</subject><subject>Cytology</subject><subject>Innervation</subject><subject>Life Sciences & Biomedicine</subject><subject>lymph node</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Lymphoid tissue</subject><subject>Medulla oblongata</subject><subject>neuroimmune regulation</subject><subject>Science & Technology</subject><subject>Sensory neurons</subject><subject>sympathetic innervation</subject><subject>Sympathetic nerves</subject><subject>Sympathetic nervous system</subject><subject>Synaptophysin</subject><issn>0021-8782</issn><issn>1469-7580</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>HGBXW</sourceid><recordid>eNqNkV9rFDEUxYNY7Nr64BeQAV8UmTZ_J8mLUJZqLYU-VJ9DJnPXzTKTbJOZlv32pt11qUKh9yUP-Z3Dufcg9J7gE1LmdBXtCWGc0ldoRnijaykUfo1mGFNSK6noIXqb8wpjwrDmb9AhY42UivEZYjebYW3HJYzeVQHSHVSdz2Py7TT6GCofquU02FD1hVtWIXaQj9HBwvYZ3u3eI_Tr2_nP-UV9df39x_zsqnYCa1qzjisqeEdZy5VlHDeOW95asIwQgRedk0JTKyRVLceEaAGaNSA7xSUQztkR-rr1XU_tAJ2DMCbbm3Xyg00bE603__4EvzS_451RVDKhWTH4tDNI8XaCPJrBZwd9bwPEKRvKtdIal2QF_fgfuopTCmU9Q4Uod6SCkkJ93lIuxZwTLPZhCDYPVRSVNY9VFPbD0_R78u_tC6C2wD20cZGdh-Bgj2GMG1puU_KVIXM_2odC5nEKY5F-ebm00Kc72veweT6yubw-22b_A4k7sgw</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Cleypool, Cindy G. 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J.</creatorcontrib><creatorcontrib>Mackaaij, Claire</creatorcontrib><creatorcontrib>Lotgerink Bruinenberg, Dyonne</creatorcontrib><creatorcontrib>Schurink, Bernadette</creatorcontrib><creatorcontrib>Bleys, Ronald L. A. W.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of anatomy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cleypool, Cindy G. J.</au><au>Mackaaij, Claire</au><au>Lotgerink Bruinenberg, Dyonne</au><au>Schurink, Bernadette</au><au>Bleys, Ronald L. A. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic nerve distribution in human lymph nodes</atitle><jtitle>Journal of anatomy</jtitle><stitle>J ANAT</stitle><addtitle>J Anat</addtitle><date>2021-08</date><risdate>2021</risdate><volume>239</volume><issue>2</issue><spage>282</spage><epage>289</epage><pages>282-289</pages><issn>0021-8782</issn><eissn>1469-7580</eissn><abstract>Various lymph node functions are regulated by the sympathetic nervous system as shown in rodent studies. If human lymph nodes show a comparable neural regulation, their afferent nerves could represent a potential therapeutic target to treat, for example, infectious or autoimmune disease. Little information is available on human lymph node innervation and the aim of this study is to establish a comprehensive and accurate representation of the presence and location of sympathetic nerves in human lymph nodes. Since previous studies mention sympathetic paravascular nerves to occasionally extent into T cell‐rich regions, the relation of these nerves with T cells was studied as well. A total number of 15 inguinal lymph nodes were resected from six donated human cadavers. Lymph node sections were stained with HE and a double T/B cell staining for evaluation of their morphology and to screen for general pathologies. A triple stain was used to identify blood vessels, sympathetic nerves and T cells, and, to study the presence and location of sympathetic nerves and their relation to T cells. To evaluate whether the observed nerves were en route to other structures or were involved in local processes, adjacent slides were stained with a marker for varicosities (synaptophysin), which presence is suggestive for synaptic activity. All lymph nodes contained sympathetic nerves, both as paravascular and discrete structures. In 15/15 lymph nodes, nerves were observed in their capsule, medulla and hilum, whereas only 13/15 lymph nodes contained nerves in their cortex. The amount of sympathetic nerves varied between compartments and between and within individuals. In general, if a lymph node contained more paravascular nerves in a specific compartment, more discrete nerves were observed as well. Occasionally, discrete nerves were observed in relation to T cells in lymphoid tissues of the cortex and medulla. Furthermore, discrete nerves were frequently present in the capsule and hilum. The presence of varicosities in a portion of these nerves, independently to their compartment, suggested a local regulatory function for these nerves. Human lymph nodes contain sympathetic nerves in their capsule, trabeculae, cortex, medulla and hilum, both as paravascular or as discrete structures. Discrete nerves were observed in relation to T cells and non‐T cell‐rich areas such as the hilar and capsular connective tissue. The presence of discrete structures suggests neural regulation of structures other than blood vessels, which was further supported by the presence of varicosities in a portion of these nerves. These observations are of relevance in further understanding neural regulation of lymph node immune responses and in the development of neuromodulatory immune therapies.
Human lymph nodes contain a significant number of sympathetic nerves (black encircled, pink stained TH positive structures). These nerves can be observed surrounding vascular structures, but also as discrete entities in the capsule, cortex, medulla and hilum. In the medulla, these nerves are frequently observed in proximity with immune cells such as T lymphocytes (CD3 positive cells as shown in the right images). Sympathetic nerves in lymph nodes might contribute to neuro immune regulation of lymph node immune function.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>33677834</pmid><doi>10.1111/joa.13422</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4993-3736</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | adrenergic innervation Anatomy & Morphology Autoimmune diseases Blood vessels Brief Communication Cadavers Connective tissues Cortex Cytology Innervation Life Sciences & Biomedicine lymph node Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Lymphoid tissue Medulla oblongata neuroimmune regulation Science & Technology Sensory neurons sympathetic innervation Sympathetic nerves Sympathetic nervous system Synaptophysin |
title | Sympathetic nerve distribution in human lymph nodes |
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