Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β 3 -adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity

Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for the bladder hypersensitive disorders including urinary urgency in overactive bladder (OAB). We aimed...

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Veröffentlicht in:	European journal of pharmacology 2021-05, Vol.899, p.173995
Hauptverfasser:	Aizawa, Naoki, Fujimori, Yoshikazu, Nakanishi, Osamu, Hayashi, Takemitsu, Goi, Yoshiaki, Kobayashi, Jun-Ichi, Fujita, Tomoe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacology Adrenergic beta-3 Receptor Agonists - pharmacology Animals Calcium Signaling Cyclic AMP - metabolism Disease Models, Animal Drug Therapy, Combination Female HEK293 Cells Humans Muscarinic Antagonists - pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta-3 - drug effects Receptors, Adrenergic, beta-3 - metabolism Thiazoles - pharmacology Tolterodine Tartrate - pharmacology TRPM Cation Channels - antagonists & inhibitors TRPM Cation Channels - metabolism Urinary Bladder - drug effects Urinary Bladder - metabolism Urinary Bladder - physiopathology Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - etiology Urinary Bladder, Overactive - metabolism Urinary Bladder, Overactive - physiopathology Urodynamics - drug effects
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