RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

Ubiquitination-dependent DNA damage response (DDR) signals play a critical role in the cellular choice of DNA damage repair pathways. Human DNA helicase RecQL4 participates in DNA replication and repair, and loss of RecQL4 is associated with autosomal recessive genetic disorders characterized by gen...

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Veröffentlicht in:	Oncogenesis (New York, NY) NY), 2021-03, Vol.10 (3), p.24-24, Article 24
Hauptverfasser:	Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Chen, Zixiang, Li, Yueyang, Li, Mengge, Wei, Di, Balajee, Adayabalam S., Fang, Hongbo, Zhao, Yongliang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/31 13/44 13/89 14/1 14/19 42/70 631/337/1427/2122 631/337/1427/2190 82/29 82/80 82/83 96/63 Apoptosis Autosomal recessive inheritance Cell Biology Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA helicase DNA repair Double-strand break repair Genetic disorders Genomic instability Human Genetics Internal Medicine Lysine Medicine Medicine & Public Health Mutants Oncology Ubiquitin Ubiquitin-protein ligase Ubiquitination Yeast
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