Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are not firmly established. Here, we study the origin of MRT by combining phyl...

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Veröffentlicht in:	Nature communications 2021-03, Vol.12 (1), p.1407-11, Article 1407
Hauptverfasser:	Custers, Lars, Khabirova, Eleonora, Coorens, Tim H. H., Oliver, Thomas R. W., Calandrini, Camilla, Young, Matthew D., Vieira Braga, Felipe A., Ellis, Peter, Mamanova, Lira, Segers, Heidi, Maat, Arie, Kool, Marcel, Hoving, Eelco W., van den Heuvel-Eibrink, Marry M., Nicholson, James, Straathof, Karin, Hook, Liz, de Krijger, Ronald R., Trayers, Claire, Allinson, Kieren, Behjati, Sam, Drost, Jarno
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 38/23 38/39 38/91 45 631/1647/2217 631/1647/767/70 631/337/2019 631/67/1678 Cancer Cell differentiation Cell Differentiation - genetics Children Differentiation DNA Methylation Drug Screening Assays, Antitumor Ectoderm Embryogenesis Fetuses Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humanities and Social Sciences Humans Mesenchyme multidisciplinary Multidisciplinary Sciences Mutation Neural crest Neural Crest - pathology Organoids Phylogenetics Phylogeny Rhabdoid Tumor - drug therapy Rhabdoid Tumor - genetics Rhabdoid Tumor - pathology Schwann cells Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Single-Cell Analysis SMARCB1 Protein - genetics Tissue Culture Techniques - methods TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors Transcription Tumors
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