The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release

Common fusion machinery mediates the Ca2+-dependent exocytosis of synaptic vesicles (SVs) and dense-core vesicles (DCVs). Previously, Synapsin Ia (Syn Ia) was found to localize to SVs, essential for mobilizing SVs to the plasma membrane through phosphorylation. However, whether (or how) the phosphop...

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Veröffentlicht in:	The Journal of neuroscience 2021-03, Vol.41 (13), p.2828-2841
Hauptverfasser:	Yang, Hui-Ju, Chen, Pin-Chun, Huang, Chien-Ting, Cheng, Tzu-Lin, Hsu, Sheng-Ping, Chen, Chien-Yu, Lu, Juu-Chin, Wang, Chih-Tien
Format:	Artikel
Sprache:	eng
Schlagworte:	Amperometry Ca2+/calmodulin-dependent protein kinase Calcium ions Calcium-binding protein Calmodulin Dense core vesicles Electrical measurement Exocytosis Immunoprecipitation Kinases Kinetics Life Sciences & Biomedicine Membrane fusion N-Ethylmaleimide-sensitive protein Neurosciences Neurosciences & Neurology Pheochromocytoma cells Phosphorylation Proteins Science & Technology SNAP receptors Synapsin Synaptic vesicles Synaptophysin Vesicles
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