Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma
The oral and oropharyngeal squamous cell carcinoma (OOSCC) accounts for 90-95% of tumours in the oral cavity. Single nucleotide polymorphism (SNP) in the coding region of PON1, tumour necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) have been associated with to development o...
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| Veröffentlicht in: | Acta odontologica Scandinavica 2021-07, Vol.79 (5), p.327-334 |
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| creator | Santana, Ingrede Tatiane Serafim dos Santos, José Nilson Andrade de Almeida, Vinicius Lima Ferreira, Waldhenice Nunes Silveira Santos, Edilmar Moura de Almeida Freitas, Roseana Pinto, Claudia Cristina Kaiser de Carvalho Barreto, Ikaro Daniel de Matos, Felipe Rodrigues |
| description | The oral and oropharyngeal squamous cell carcinoma (OOSCC) accounts for 90-95% of tumours in the oral cavity. Single nucleotide polymorphism (SNP) in the coding region of PON1, tumour necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) have been associated with to development of different cancers. Our aim was to investigate the prognostic value of PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs in OOSCC.
We genotyped 163 OOSCC patients and 146 patients from group of control for PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs by real-time polymerase chain reaction (PCR).
TNF-α (rs1800629) GG genotype was significantly more frequent in intraoral lesions and clinical stages III and IV, while the polymorphic AA genotype in lip lesion and clinical stages I and II. Moreover, TGF-β (rs1800469) AG and AA genotypes were significantly more frequent in larger tumours (T3 e T4). TNF-α (rs1800629) AG genotype had poor survival and patients carrying the PON1 (rs662) TT genotype tended to poor survival.
Results suggest that the rs1800629 and rs1800469 could exert influence in the more aggressive behaviour of OOSCC and the genotypes AG of rs1800629, and TT of rs662 could be markers with prognostic value in OOSCC. |
| doi_str_mv | 10.1080/00016357.2020.1850856 |
| format | Article |
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We genotyped 163 OOSCC patients and 146 patients from group of control for PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs by real-time polymerase chain reaction (PCR).
TNF-α (rs1800629) GG genotype was significantly more frequent in intraoral lesions and clinical stages III and IV, while the polymorphic AA genotype in lip lesion and clinical stages I and II. Moreover, TGF-β (rs1800469) AG and AA genotypes were significantly more frequent in larger tumours (T3 e T4). TNF-α (rs1800629) AG genotype had poor survival and patients carrying the PON1 (rs662) TT genotype tended to poor survival.
Results suggest that the rs1800629 and rs1800469 could exert influence in the more aggressive behaviour of OOSCC and the genotypes AG of rs1800629, and TT of rs662 could be markers with prognostic value in OOSCC.</description><identifier>ISSN: 0001-6357</identifier><identifier>EISSN: 1502-3850</identifier><identifier>DOI: 10.1080/00016357.2020.1850856</identifier><identifier>PMID: 33587860</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Aryldialkylphosphatase - genetics ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Head and Neck Neoplasms ; Humans ; Oral cancer ; Polymorphism, Single Nucleotide ; PON1 ; Prognosis ; SNP ; Squamous Cell Carcinoma of Head and Neck ; TGF-β ; TNF-α ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha - genetics</subject><ispartof>Acta odontologica Scandinavica, 2021-07, Vol.79 (5), p.327-334</ispartof><rights>2021 Acta Odontologica Scandinavica Society 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-c35616fb4e5abc5b31111277df591190eddffe919686871ada14266a85221b413</citedby><cites>FETCH-LOGICAL-c366t-c35616fb4e5abc5b31111277df591190eddffe919686871ada14266a85221b413</cites><orcidid>0000-0002-2980-6302</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33587860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santana, Ingrede Tatiane Serafim</creatorcontrib><creatorcontrib>dos Santos, José Nilson Andrade</creatorcontrib><creatorcontrib>de Almeida, Vinicius Lima</creatorcontrib><creatorcontrib>Ferreira, Waldhenice Nunes Silveira</creatorcontrib><creatorcontrib>Santos, Edilmar Moura</creatorcontrib><creatorcontrib>de Almeida Freitas, Roseana</creatorcontrib><creatorcontrib>Pinto, Claudia Cristina Kaiser</creatorcontrib><creatorcontrib>de Carvalho Barreto, Ikaro Daniel</creatorcontrib><creatorcontrib>de Matos, Felipe Rodrigues</creatorcontrib><title>Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma</title><title>Acta odontologica Scandinavica</title><addtitle>Acta Odontol Scand</addtitle><description>The oral and oropharyngeal squamous cell carcinoma (OOSCC) accounts for 90-95% of tumours in the oral cavity. Single nucleotide polymorphism (SNP) in the coding region of PON1, tumour necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) have been associated with to development of different cancers. Our aim was to investigate the prognostic value of PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs in OOSCC.
We genotyped 163 OOSCC patients and 146 patients from group of control for PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs by real-time polymerase chain reaction (PCR).
TNF-α (rs1800629) GG genotype was significantly more frequent in intraoral lesions and clinical stages III and IV, while the polymorphic AA genotype in lip lesion and clinical stages I and II. Moreover, TGF-β (rs1800469) AG and AA genotypes were significantly more frequent in larger tumours (T3 e T4). TNF-α (rs1800629) AG genotype had poor survival and patients carrying the PON1 (rs662) TT genotype tended to poor survival.
Results suggest that the rs1800629 and rs1800469 could exert influence in the more aggressive behaviour of OOSCC and the genotypes AG of rs1800629, and TT of rs662 could be markers with prognostic value in OOSCC.</description><subject>Aryldialkylphosphatase - genetics</subject><subject>Case-Control Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Oral cancer</subject><subject>Polymorphism, Single Nucleotide</subject><subject>PON1</subject><subject>Prognosis</subject><subject>SNP</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>TGF-β</subject><subject>TNF-α</subject><subject>Transforming Growth Factor beta</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>0001-6357</issn><issn>1502-3850</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OxCAUhYnR6PjzCBqWLqxy20LpTmP8S4y6GNeEtjCDaaFCJ2Z8K30Qn0nqjC5lAdyb73APB6FDIKdAODkjhADLaHGakjS2OCWcsg00AUrSJIvlJpqMTDJCO2g3hJdY5iUvt9FOllFecEYm6P0iBFcbORhnsdP46fEBTvD04Tr5-sDSNnh6E6-feKaswr1rl53z_dyELuA3M8xx793MumACNlHvZfsjct71c-mXdqZiJ7wuZOcWAdeqbXEtfW2s6-Q-2tKyDepgfe6h5-ur6eVtcv94c3d5cZ_UGWND3CkDpqtcUVnVtMogrrQoGk1LgJKoptFalVAyzngBspGQp4xJTtMUqhyyPXS8ejd6fV2oMIjOhNGKtCq6EmleEgDOf1C6QmvvQvBKi96bLn5EABFj7OI3djHGLtaxR93ResSi6lTzp_rNOQLnK8BY7Xwn35xvGzHIZeu89tLWJojs_xnfqOOSpw</recordid><startdate>20210704</startdate><enddate>20210704</enddate><creator>Santana, Ingrede Tatiane Serafim</creator><creator>dos Santos, José Nilson Andrade</creator><creator>de Almeida, Vinicius Lima</creator><creator>Ferreira, Waldhenice Nunes Silveira</creator><creator>Santos, Edilmar Moura</creator><creator>de Almeida Freitas, Roseana</creator><creator>Pinto, Claudia Cristina Kaiser</creator><creator>de Carvalho Barreto, Ikaro Daniel</creator><creator>de Matos, Felipe Rodrigues</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2980-6302</orcidid></search><sort><creationdate>20210704</creationdate><title>Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma</title><author>Santana, Ingrede Tatiane Serafim ; dos Santos, José Nilson Andrade ; de Almeida, Vinicius Lima ; Ferreira, Waldhenice Nunes Silveira ; Santos, Edilmar Moura ; de Almeida Freitas, Roseana ; Pinto, Claudia Cristina Kaiser ; de Carvalho Barreto, Ikaro Daniel ; de Matos, Felipe Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-c35616fb4e5abc5b31111277df591190eddffe919686871ada14266a85221b413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aryldialkylphosphatase - genetics</topic><topic>Case-Control Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Oral cancer</topic><topic>Polymorphism, Single Nucleotide</topic><topic>PON1</topic><topic>Prognosis</topic><topic>SNP</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>TGF-β</topic><topic>TNF-α</topic><topic>Transforming Growth Factor beta</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santana, Ingrede Tatiane Serafim</creatorcontrib><creatorcontrib>dos Santos, José Nilson Andrade</creatorcontrib><creatorcontrib>de Almeida, Vinicius Lima</creatorcontrib><creatorcontrib>Ferreira, Waldhenice Nunes Silveira</creatorcontrib><creatorcontrib>Santos, Edilmar Moura</creatorcontrib><creatorcontrib>de Almeida Freitas, Roseana</creatorcontrib><creatorcontrib>Pinto, Claudia Cristina Kaiser</creatorcontrib><creatorcontrib>de Carvalho Barreto, Ikaro Daniel</creatorcontrib><creatorcontrib>de Matos, Felipe Rodrigues</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta odontologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santana, Ingrede Tatiane Serafim</au><au>dos Santos, José Nilson Andrade</au><au>de Almeida, Vinicius Lima</au><au>Ferreira, Waldhenice Nunes Silveira</au><au>Santos, Edilmar Moura</au><au>de Almeida Freitas, Roseana</au><au>Pinto, Claudia Cristina Kaiser</au><au>de Carvalho Barreto, Ikaro Daniel</au><au>de Matos, Felipe Rodrigues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma</atitle><jtitle>Acta odontologica Scandinavica</jtitle><addtitle>Acta Odontol Scand</addtitle><date>2021-07-04</date><risdate>2021</risdate><volume>79</volume><issue>5</issue><spage>327</spage><epage>334</epage><pages>327-334</pages><issn>0001-6357</issn><eissn>1502-3850</eissn><abstract>The oral and oropharyngeal squamous cell carcinoma (OOSCC) accounts for 90-95% of tumours in the oral cavity. Single nucleotide polymorphism (SNP) in the coding region of PON1, tumour necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) have been associated with to development of different cancers. Our aim was to investigate the prognostic value of PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs in OOSCC.
We genotyped 163 OOSCC patients and 146 patients from group of control for PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs by real-time polymerase chain reaction (PCR).
TNF-α (rs1800629) GG genotype was significantly more frequent in intraoral lesions and clinical stages III and IV, while the polymorphic AA genotype in lip lesion and clinical stages I and II. Moreover, TGF-β (rs1800469) AG and AA genotypes were significantly more frequent in larger tumours (T3 e T4). TNF-α (rs1800629) AG genotype had poor survival and patients carrying the PON1 (rs662) TT genotype tended to poor survival.
Results suggest that the rs1800629 and rs1800469 could exert influence in the more aggressive behaviour of OOSCC and the genotypes AG of rs1800629, and TT of rs662 could be markers with prognostic value in OOSCC.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>33587860</pmid><doi>10.1080/00016357.2020.1850856</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2980-6302</orcidid></addata></record> |
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| ispartof | Acta odontologica Scandinavica, 2021-07, Vol.79 (5), p.327-334 |
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| subjects | Aryldialkylphosphatase - genetics Case-Control Studies Genetic Predisposition to Disease Genotype Head and Neck Neoplasms Humans Oral cancer Polymorphism, Single Nucleotide PON1 Prognosis SNP Squamous Cell Carcinoma of Head and Neck TGF-β TNF-α Transforming Growth Factor beta Tumor Necrosis Factor-alpha - genetics |
| title | Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma |
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