Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment

The development of suitable drug delivery carriers is significant in biomedical applications to improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the way for the formulation of variety of drug carriers. The brain disorders such as ischemic stroke, brain cancer, a...

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Veröffentlicht in:	Drug delivery 2021-01, Vol.28 (1), p.380-389
Hauptverfasser:	Lu, Xianfeng, Zhang, Yaohui, Wang, Lixiang, Li, Guichen, Gao, Jianyuan, Wang, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biological Transport - drug effects Blood-brain barrier Blood-Brain Barrier - metabolism Brain - drug effects Brain - metabolism Brain cancer Brain diseases Brain Ischemia - drug therapy Carnosine - chemistry Cell Line Clinical psychology dexamethasone Dexamethasone - pharmacology Drug Carriers - chemistry Drug delivery systems Drug Delivery Systems - methods Drugs Geriatrics Hospitals Humans ischemic stroke Ischemic Stroke - drug therapy L-carnosine Lactic Acid - chemistry Magnetic Iron Oxide Nanoparticles - chemistry Magnetic nanoparticles Nanoparticles Nanoparticles - chemistry Neurology Particle Size Peptides - metabolism PLGA polymer Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polymers Steroids Stroke
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