Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, translation and cell proliferation. Ornithine decarboxyla...

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Veröffentlicht in:	Nature communications 2021-02, Vol.12 (1), p.971-13, Article 971
Hauptverfasser:	Khan, Aaminah, Gamble, Laura D., Upton, Dannielle H., Ung, Caitlin, Yu, Denise M. T., Ehteda, Anahid, Pandher, Ruby, Mayoh, Chelsea, Hébert, Steven, Jabado, Nada, Kleinman, Claudia L., Burns, Mark R., Norris, Murray D., Haber, Michelle, Tsoli, Maria, Ziegler, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38/39 59/5 631/67/1922 692/308/2778 Animal models Animals Biological Transport - drug effects Brain Brain cancer Brain Stem Neoplasms - drug therapy Brain tumors Cell Death - drug effects Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Children Dicarboxylic Acid Transporters Diffuse Intrinsic Pontine Glioma - drug therapy Disease Models, Animal DNA biosynthesis DNA Replication - drug effects Eflornithine Eflornithine - pharmacology Eflornithine - therapeutic use Female Gene Expression Regulation, Neoplastic - drug effects Glioma Humanities and Social Sciences Humans Mice Mice, Inbred BALB C Mice, Nude Mitochondrial Membrane Transport Proteins multidisciplinary Multidisciplinary Sciences Ornithine decarboxylase Ornithine Decarboxylase - drug effects Ornithine Decarboxylase - metabolism Polyamines Polyamines - metabolism Polyamines - pharmacology Polyamines - therapeutic use Polycations Polyelectrolytes Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Survival Synthesis Tumors
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