Phorbol Ester-Induced Terminal Differentiation is Inhibited in Human U-937 Monoblastic Cells Expressing a v-myc Oncogene

Induction of differentiation of the human monoblastic cell line U-937 in vitro by several physiologic and nonphysiologic inducers is accompanied by a rapid decrease in expression of MYC, the endogenous human myc protooncogene. To investigate whether this reduction is a prerequisite for terminal diff...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1988-04, Vol.85 (8), p.2638-2642
Hauptverfasser:	Larsson, Lars-Gunnar, Ivhed, Irene, Gidlund, Magnus, Pettersson, Ulf, Vennström, Björn, Nilsson, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	550301 - Cytology- Tracer Techniques 560300 - Chemicals Metabolism & Toxicology ANIMAL CELLS ANIMALS Antibody-Dependent Cell Cytotoxicity AUTORADIOGRAPHY BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BLOOD FORMATION BONE MARROW CELLS CARCINOGENESIS CARCINOGENS Cell Adhesion CELL DIFFERENTIATION Cell Differentiation - drug effects Cell Division - drug effects Cell Line Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Cellular differentiation Cellular immunity CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES Endothelial cells ESTERS Fundamental and applied biological sciences. Psychology Gene Expression Regulation GENES Humans ISOTOPES Killer Cells, Natural - immunology LABELLED COMPOUNDS LIGHT NUCLEI MAMMALS MAN Messenger RNA Molecular and cellular biology Monocytes - cytology Monocytes - immunology myc genes Natural killer cells NUCLEI ODD-ODD NUCLEI Oncogene Proteins, Viral - genetics ONCOGENES ORGANIC COMPOUNDS PATHOGENESIS PHORBOL ESTERS PHOSPHORUS 32 PHOSPHORUS ISOTOPES PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RNA RNA, Messenger - genetics SOMATIC CELLS Tetradecanoylphorbol Acetate - pharmacology TRITIUM COMPOUNDS TUMOR CELLS VERTEBRATES
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