HSD11B1 is upregulated synergistically by IFNγ and TNFα and mediates TSG-6 expression in human UC-MSCs

Inflammatory factors such as IFNγ and TNFα could endow mesenchymal stem cells (MSCs) a potent immunomodulatory property, a process called licensing, but the mechanisms are not fully understood. We here found that glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), whi...

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Veröffentlicht in:	Cell death discovery 2020-04, Vol.6 (1), p.24
Hauptverfasser:	Huang, Peiqing, Li, Yinghong, Xu, Chenchang, Melino, Gerry, Shao, Changshun, Shi, Yufang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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