Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies

The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First, the phase solubility diagram of MA in β-CD was drawn from 0 to 21 × 10 −3 M of β-CD concentration. A job's plot experiment was used to...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2021-01, Vol.36 (1), p.605-617
Hauptverfasser:	Sid, Dounia, Baitiche, Milad, Elbahri, Zineb, Djerboua, Ferhat, Boutahala, Mokhtar, Bouaziz, Zouhair, Le Borgne, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Cyclodextrins - chemistry beta-Cyclodextrins - pharmacology Cattle characterisation Chemical Sciences Erythrocytes - drug effects Galenic pharmacology Humans in vitro studies Life Sciences Medication Medicinal Chemistry Mefenamic acid Mefenamic Acid - chemistry Mefenamic Acid - pharmacology Models, Molecular Molecular Structure Pharmaceutical sciences Pharmacology Protein Denaturation - drug effects Quantitative Methods Research Paper Serum Albumin, Bovine - chemistry Solubility β-cyclodextrin inclusion complexes
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