The association of stromal mesenchymal cells with the bone substitute for the treatment of non-union of long bones, an alternative to autologous spongy grafts: a case report
Bone is the most transplanted human tissue. Surgical interventions for bone repair are necessary for various pathologies such as nonunion, osteoporosis or osteonecrosis. Although autologous bone grafts remain the benchmark for bone regeneration, they unfortunately have a number of disadvantages: the...
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| Veröffentlicht in: | The Pan African medical journal 2020-11, Vol.37, p.234 |
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| creator | Chagou, Aniss Benameur, Hamza Hassoun, Jalal Abdeloihab, Jaafar |
| description | Bone is the most transplanted human tissue. Surgical interventions for bone repair are necessary for various pathologies such as nonunion, osteoporosis or osteonecrosis. Although autologous bone grafts remain the benchmark for bone regeneration, they unfortunately have a number of disadvantages: the need for a second intervention and the limited amount of tissue removed. Synthetic bone substitutes overcome some of these drawbacks, but their osteoinductive properties do not make it possible to treat significant bone losses. Cellular therapies based on mesenchymal stromal stem cells (MSC) in combination with bone substitutes may be alternatives to autologous bone grafting. It is in this context that we report the case of a patient with congenital dysplasia treated for non-union of the femur. The association of mesenchymal stem cells with bone substitute allowed us to obtain consolidation after 6 months. |
| doi_str_mv | 10.11604/pamj.2020.37.234.22809 |
| format | Article |
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The association of mesenchymal stem cells with bone substitute allowed us to obtain consolidation after 6 months.</description><subject>Bone Regeneration - physiology</subject><subject>Bone Substitutes - metabolism</subject><subject>Female</subject><subject>Femur - metabolism</subject><subject>Femur - pathology</subject><subject>Hip Dislocation, Congenital - therapy</subject><subject>Humans</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Young Adult</subject><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kNtKw0AQhhdBbK2-gs4DmLiHNNl4J8UTFLyp12WynbQpyW7Y3Sh9KN_RtOrVDMP_fQM_Y7eCp0LkPLvvsdunkkueqiKVKkul1Lw8Y1NRqiLRudYTdhnCnvM814pfsIlS87lUczll36sdAYbgTIOxcRZcDSF612ELHQWyZnc47obaNsBXE3cQR6JyliAMVYhNHCJB7fzpHj1h7MjGo8c6mwz2T9o6uz1h4Q7QAraRvB1ffo6QAxyia93WDQFCPyYPsPVYx_AACAYDgafe-XjFzmtsA13_zRn7eH5aLV6T5fvL2-JxmfSC65gUCrEsVU2GjDJlXlSos8KUZqxCCKLCGENaCpSSZ6ilrDKJWBVUZtlGGaVm7ObX2w9VR5t175sO_WH935v6Ac2vdOU</recordid><startdate>20201113</startdate><enddate>20201113</enddate><creator>Chagou, Aniss</creator><creator>Benameur, Hamza</creator><creator>Hassoun, Jalal</creator><creator>Abdeloihab, Jaafar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20201113</creationdate><title>The association of stromal mesenchymal cells with the bone substitute for the treatment of non-union of long bones, an alternative to autologous spongy grafts: a case report</title><author>Chagou, Aniss ; Benameur, Hamza ; Hassoun, Jalal ; Abdeloihab, Jaafar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p108t-73aa993fecec3c967ba847c9c68811ee7ccce821a2204a822b42aab7e944d3c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2020</creationdate><topic>Bone Regeneration - physiology</topic><topic>Bone Substitutes - metabolism</topic><topic>Female</topic><topic>Femur - metabolism</topic><topic>Femur - pathology</topic><topic>Hip Dislocation, Congenital - therapy</topic><topic>Humans</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chagou, Aniss</creatorcontrib><creatorcontrib>Benameur, Hamza</creatorcontrib><creatorcontrib>Hassoun, Jalal</creatorcontrib><creatorcontrib>Abdeloihab, Jaafar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chagou, Aniss</au><au>Benameur, Hamza</au><au>Hassoun, Jalal</au><au>Abdeloihab, Jaafar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of stromal mesenchymal cells with the bone substitute for the treatment of non-union of long bones, an alternative to autologous spongy grafts: a case report</atitle><jtitle>The Pan African medical journal</jtitle><addtitle>Pan Afr Med J</addtitle><date>2020-11-13</date><risdate>2020</risdate><volume>37</volume><spage>234</spage><pages>234-</pages><eissn>1937-8688</eissn><abstract>Bone is the most transplanted human tissue. Surgical interventions for bone repair are necessary for various pathologies such as nonunion, osteoporosis or osteonecrosis. Although autologous bone grafts remain the benchmark for bone regeneration, they unfortunately have a number of disadvantages: the need for a second intervention and the limited amount of tissue removed. Synthetic bone substitutes overcome some of these drawbacks, but their osteoinductive properties do not make it possible to treat significant bone losses. Cellular therapies based on mesenchymal stromal stem cells (MSC) in combination with bone substitutes may be alternatives to autologous bone grafting. It is in this context that we report the case of a patient with congenital dysplasia treated for non-union of the femur. 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| ispartof | The Pan African medical journal, 2020-11, Vol.37, p.234 |
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| source | MEDLINE; Directory of Open Access Journals; PubMed Central Open Access; African Journals Online Free (AJOL); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Bone Regeneration - physiology Bone Substitutes - metabolism Female Femur - metabolism Femur - pathology Hip Dislocation, Congenital - therapy Humans Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - cytology Young Adult |
| title | The association of stromal mesenchymal cells with the bone substitute for the treatment of non-union of long bones, an alternative to autologous spongy grafts: a case report |
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