Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy
Background Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and the effectiveness of antimicrobial therapy in children with febrile UTIs. Methods Clinical records of 108 patients (130 episodes) with...
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| Veröffentlicht in: | Pediatrics international 2021-10, Vol.63 (10), p.1198-1204 |
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| creator | Tanaka, Yuhei Oishi, Tomohiro Ono, Sahoko Kono, Mina Kato, Atsushi Miyata, Ippei Ohno, Naoki Ouchi, Kazunobu |
| description | Background
Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and the effectiveness of antimicrobial therapy in children with febrile UTIs.
Methods
Clinical records of 108 patients (130 episodes) with febrile UTIs admitted to the Kawasaki Medical School Hospital between July 2009 and October 2016 were retrospectively reviewed. The characteristics of the causative bacteria, antibacterial therapy, and therapeutic effect were verified.
Results
Patients were aged between 0 and 183 months (median age: 3 months). Seventy‐three (67.6%) were males. Sixty‐three episodes (48.5%) were diagnosed with complicated UTIs. Forty‐seven episodes (36.2%) were observed in patients aged |
| doi_str_mv | 10.1111/ped.14639 |
| format | Article |
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Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and the effectiveness of antimicrobial therapy in children with febrile UTIs.
Methods
Clinical records of 108 patients (130 episodes) with febrile UTIs admitted to the Kawasaki Medical School Hospital between July 2009 and October 2016 were retrospectively reviewed. The characteristics of the causative bacteria, antibacterial therapy, and therapeutic effect were verified.
Results
Patients were aged between 0 and 183 months (median age: 3 months). Seventy‐three (67.6%) were males. Sixty‐three episodes (48.5%) were diagnosed with complicated UTIs. Forty‐seven episodes (36.2%) were observed in patients aged <3 months; 15 of them had complicated UTIs. Escherichia coli (E. coli) was the most common pathogen, followed by Enterococcus faecalis (E. faecalis). Blood cultures were positive in three episodes. Among the 130 episodes, 62 (47.7%) were treated with a combination of ampicillin and third‐generation cephalosporins, followed by third‐generation cephalosporins (31 episodes, 23.8%) and sulbactam sodium / ampicillin sodium (15 episodes, 11.5%). In case of patients with uncomplicated/complicated UTIs and patients aged <3 and ≥3 months, the most common pathogen was E. coli, followed by E. faecalis. There was no difference in therapeutic effects between “combination ampicillin and third‐generation cephalosporins” and “third‐generation cephalosporin monotherapy” administered for the treatment of UTIs caused by E. coli.
Conclusions
Escherichia coli is the most common pathogen among pediatric UTIs. For antibacterial therapy, third‐generation cephalosporin monotherapy is effective and may not require combination therapy with ampicillin.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.14639</identifier><identifier>PMID: 33544943</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Age Factors ; Ampicillin ; Anti-Bacterial Agents - therapeutic use ; Antimicrobial agents ; anti‐bacterial agents ; Bacteria ; Bacterial infections ; Catheters, Indwelling ; Cephalosporins ; child ; Children ; E coli ; Epidemiology ; Escherichia coli ; Female ; Humans ; Infant ; Japan ; Life Sciences & Biomedicine ; Male ; Pathogens ; Patients ; Pediatrics ; Retrospective Studies ; Science & Technology ; Sex Factors ; Sulbactam ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urinary Tract Infections - drug therapy ; Urinary Tract Infections - epidemiology ; Urogenital system</subject><ispartof>Pediatrics international, 2021-10, Vol.63 (10), p.1198-1204</ispartof><rights>2021 Japan Pediatric Society</rights><rights>2021 Japan Pediatric Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>4</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000696390700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3779-2e4ca3bbe6aa40044ff57345c3cd87118ce55fef03c502ffa9beb6a7da81fee43</citedby><cites>FETCH-LOGICAL-c3779-2e4ca3bbe6aa40044ff57345c3cd87118ce55fef03c502ffa9beb6a7da81fee43</cites><orcidid>0000-0002-9963-0832 ; 0000-0003-3842-3044</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.14639$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.14639$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33544943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Yuhei</creatorcontrib><creatorcontrib>Oishi, Tomohiro</creatorcontrib><creatorcontrib>Ono, Sahoko</creatorcontrib><creatorcontrib>Kono, Mina</creatorcontrib><creatorcontrib>Kato, Atsushi</creatorcontrib><creatorcontrib>Miyata, Ippei</creatorcontrib><creatorcontrib>Ohno, Naoki</creatorcontrib><creatorcontrib>Ouchi, Kazunobu</creatorcontrib><title>Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy</title><title>Pediatrics international</title><addtitle>PEDIATR INT</addtitle><addtitle>Pediatr Int</addtitle><description>Background
Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and the effectiveness of antimicrobial therapy in children with febrile UTIs.
Methods
Clinical records of 108 patients (130 episodes) with febrile UTIs admitted to the Kawasaki Medical School Hospital between July 2009 and October 2016 were retrospectively reviewed. The characteristics of the causative bacteria, antibacterial therapy, and therapeutic effect were verified.
Results
Patients were aged between 0 and 183 months (median age: 3 months). Seventy‐three (67.6%) were males. Sixty‐three episodes (48.5%) were diagnosed with complicated UTIs. Forty‐seven episodes (36.2%) were observed in patients aged <3 months; 15 of them had complicated UTIs. Escherichia coli (E. coli) was the most common pathogen, followed by Enterococcus faecalis (E. faecalis). Blood cultures were positive in three episodes. Among the 130 episodes, 62 (47.7%) were treated with a combination of ampicillin and third‐generation cephalosporins, followed by third‐generation cephalosporins (31 episodes, 23.8%) and sulbactam sodium / ampicillin sodium (15 episodes, 11.5%). In case of patients with uncomplicated/complicated UTIs and patients aged <3 and ≥3 months, the most common pathogen was E. coli, followed by E. faecalis. There was no difference in therapeutic effects between “combination ampicillin and third‐generation cephalosporins” and “third‐generation cephalosporin monotherapy” administered for the treatment of UTIs caused by E. coli.
Conclusions
Escherichia coli is the most common pathogen among pediatric UTIs. For antibacterial therapy, third‐generation cephalosporin monotherapy is effective and may not require combination therapy with ampicillin.</description><subject>Age Factors</subject><subject>Ampicillin</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antimicrobial agents</subject><subject>anti‐bacterial agents</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Catheters, Indwelling</subject><subject>Cephalosporins</subject><subject>child</subject><subject>Children</subject><subject>E coli</subject><subject>Epidemiology</subject><subject>Escherichia coli</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Japan</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Sex Factors</subject><subject>Sulbactam</subject><subject>Urinary tract</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - drug therapy</subject><subject>Urinary Tract Infections - epidemiology</subject><subject>Urogenital system</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU1rFTEUhoMotl5d-Ack4EaRaZNJ5qs7Ga-2UKgLBXchyZzYlJlkTGaU--97rvfWhSAYCDmE57ycPCHkJWdnHNf5DMMZl7XoHpFTLmVZlIx9e4y1KNuiZXVzQp7lfMcYa5tWPiUnQlRSdlKcErOd_QCTj2P8vqPR0TX5oNOOLknbhfrgwC4-howltbd-HBKEC9rrNevF_wRqEIPkNdVhwL34ydsUjdcjXW4h6Xn3nDxxeszw4nhuyNeP2y_9ZXF98-mqf39dWNE0XVGCtFoYA7XWkjEpnasaISsr7NA2nLcWqsqBY8JWrHROdwZMrZtBt9wBSLEhbw65c4o_VsiLmny2MI46QFyzKiXGVILVFaKv_0Lv4poCTqfKCoV1fG9nQ94eKHxQzgmcmpOfUI7iTO3FKxSvfotH9tUxcTUT3j6QD6YRaA_ALzDRZeshWPiD4dfUHeawBivGe7_ovfU-rmHB1nf_34r0-ZH2I-z-PbL6vP1wmP0e0Miu8w</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Tanaka, Yuhei</creator><creator>Oishi, Tomohiro</creator><creator>Ono, Sahoko</creator><creator>Kono, Mina</creator><creator>Kato, Atsushi</creator><creator>Miyata, Ippei</creator><creator>Ohno, Naoki</creator><creator>Ouchi, Kazunobu</creator><general>Wiley</general><general>Blackwell Publishing Ltd</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9963-0832</orcidid><orcidid>https://orcid.org/0000-0003-3842-3044</orcidid></search><sort><creationdate>202110</creationdate><title>Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy</title><author>Tanaka, Yuhei ; Oishi, Tomohiro ; Ono, Sahoko ; Kono, Mina ; Kato, Atsushi ; Miyata, Ippei ; Ohno, Naoki ; Ouchi, Kazunobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3779-2e4ca3bbe6aa40044ff57345c3cd87118ce55fef03c502ffa9beb6a7da81fee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age Factors</topic><topic>Ampicillin</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antimicrobial agents</topic><topic>anti‐bacterial agents</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Catheters, Indwelling</topic><topic>Cephalosporins</topic><topic>child</topic><topic>Children</topic><topic>E coli</topic><topic>Epidemiology</topic><topic>Escherichia coli</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Japan</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Sex Factors</topic><topic>Sulbactam</topic><topic>Urinary tract</topic><topic>Urinary tract diseases</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - drug therapy</topic><topic>Urinary Tract Infections - epidemiology</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Yuhei</creatorcontrib><creatorcontrib>Oishi, Tomohiro</creatorcontrib><creatorcontrib>Ono, Sahoko</creatorcontrib><creatorcontrib>Kono, Mina</creatorcontrib><creatorcontrib>Kato, Atsushi</creatorcontrib><creatorcontrib>Miyata, Ippei</creatorcontrib><creatorcontrib>Ohno, Naoki</creatorcontrib><creatorcontrib>Ouchi, Kazunobu</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Yuhei</au><au>Oishi, Tomohiro</au><au>Ono, Sahoko</au><au>Kono, Mina</au><au>Kato, Atsushi</au><au>Miyata, Ippei</au><au>Ohno, Naoki</au><au>Ouchi, Kazunobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy</atitle><jtitle>Pediatrics international</jtitle><stitle>PEDIATR INT</stitle><addtitle>Pediatr Int</addtitle><date>2021-10</date><risdate>2021</risdate><volume>63</volume><issue>10</issue><spage>1198</spage><epage>1204</epage><pages>1198-1204</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and the effectiveness of antimicrobial therapy in children with febrile UTIs.
Methods
Clinical records of 108 patients (130 episodes) with febrile UTIs admitted to the Kawasaki Medical School Hospital between July 2009 and October 2016 were retrospectively reviewed. The characteristics of the causative bacteria, antibacterial therapy, and therapeutic effect were verified.
Results
Patients were aged between 0 and 183 months (median age: 3 months). Seventy‐three (67.6%) were males. Sixty‐three episodes (48.5%) were diagnosed with complicated UTIs. Forty‐seven episodes (36.2%) were observed in patients aged <3 months; 15 of them had complicated UTIs. Escherichia coli (E. coli) was the most common pathogen, followed by Enterococcus faecalis (E. faecalis). Blood cultures were positive in three episodes. Among the 130 episodes, 62 (47.7%) were treated with a combination of ampicillin and third‐generation cephalosporins, followed by third‐generation cephalosporins (31 episodes, 23.8%) and sulbactam sodium / ampicillin sodium (15 episodes, 11.5%). In case of patients with uncomplicated/complicated UTIs and patients aged <3 and ≥3 months, the most common pathogen was E. coli, followed by E. faecalis. There was no difference in therapeutic effects between “combination ampicillin and third‐generation cephalosporins” and “third‐generation cephalosporin monotherapy” administered for the treatment of UTIs caused by E. coli.
Conclusions
Escherichia coli is the most common pathogen among pediatric UTIs. For antibacterial therapy, third‐generation cephalosporin monotherapy is effective and may not require combination therapy with ampicillin.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>33544943</pmid><doi>10.1111/ped.14639</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9963-0832</orcidid><orcidid>https://orcid.org/0000-0003-3842-3044</orcidid></addata></record> |
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| subjects | Age Factors Ampicillin Anti-Bacterial Agents - therapeutic use Antimicrobial agents anti‐bacterial agents Bacteria Bacterial infections Catheters, Indwelling Cephalosporins child Children E coli Epidemiology Escherichia coli Female Humans Infant Japan Life Sciences & Biomedicine Male Pathogens Patients Pediatrics Retrospective Studies Science & Technology Sex Factors Sulbactam Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - drug therapy Urinary Tract Infections - epidemiology Urogenital system |
| title | Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy |
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